Konstantinos Stellos

Prof. Dr. Konstantinos Stellos

VI. Department of Medicine (Angiology and Diabetology), Interdisciplinary Vascular Center (IGZ) andEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Konstantinos.Stellos(at)umm.de

Professional Career

Since 2025

Full Professor (W3) and Chair of Internal Medicine, Angiology and Diabetology

Medical Faculty Mannheim, Heidelberg University, Germany

Director, VI. Department of Medicine (Vascular Medicine and Diabetology)
University Hospital Heidelberg – UK Mannheim, Mannheim, Germany

Head, Interdisciplinary Vascular Center (IGZ) Mannheim
University Hospital Heidelberg – UK Mannheim, Mannheim, Germany

2021 - 2025

Full Professor (W3) and Chair of Cardiovascular Research
European Center for Angioscience, Medical Faculty

Mannheim, Heidelberg University, Germany

2021 - 2025

Senior Physician (Oberarzt)
Department of Medicine I and Interdisciplinary Vascular Center (IGZ), University Medical Center Mannheim, Germany

2019 - 2021

Lead, Vascular Medicine and Biology
Newcastle University and Newcastle Hospitals

NHS Foundation Trust, Newcastle upon Tyne, UK

2018 - 2021

Honorary Consultant Cardiologist
Freeman Hospital, Newcastle Hospitals NHS Foundation Trust,

Newcastle upon Tyne, UK

2017 - 2021

Full Professor and Chair of Cardiovascular Medicine
Newcastle University, Newcastle upon Tyne, UK

2014 - 2017

Associate Professor of Medicine (Cardiovascular Medicine) (Außerplanmäßiger Professor)

Department of Medicine III, Cardiology and Angiology, University Hospital Frankfurt, Goethe University Frankfurt, Germany

2013 - 2014

Assistant Professor of Medicine

(Cardiovascular Medicine) (Privatdozent)

Department of Medicine III, Cardiology and Angiology, University

Hospital Frankfurt, Goethe University Frankfurt, Germanyy

2011 - 2017

Group Leader, Institute for Cardiovascular Regeneration
Goethe University Frankfurt, Germany

2007

MD (Dr. med.), summa cum laude
Eberhard Karls University of Tübingen, Germany

Selected Publications

Sopova K, Delialis D, Aivalioti E, Georgiopoulos G, Athanasopoulos S, Zervas G, Konstantaki C, Sachse M, Sigl M, Duerschmied D, Tual-Chalot S, Stamatelopoulos K*, Stellos K*: Amyloid-beta (1-40) peptide is associated with systemic metabolic health. Eur J Clin Invest, 2026;56(1):e70171, doi: 10.1111/eci.70171. (*equal contribution)

Wenzl FA, Kofoed KF, Simonsson M, Ambler G, van der Sangen NMR, Lampa E, Bruno F, de Belder MA, Hlasensky J, Mueller-Hennessen M, Smolle MA, Wang P, Henriques JPS, Kikkert WJ, Kelbæk H, Bouček L, Raposeiras-Roubín S, Abu-Assi E, Azzahhafi J, Velders MA, Stellos K, Engstrøm T, Chan Pin Yin DRPP, Weston C, Adlam D, Rickli H, Giannitsis E, Radovanovic D, Parenica J, Antoniades CA, Fox KAA, D'Ascenzo F, Ten Berg JM, Køber LV, James S, Deanfield J, Lüscher TF: Extension of the GRACE score for non-ST-elevation acute coronary syndrome: a development and validation study in ten countries. Lancet Digit Health, 2025;7(10):100907, doi: 10.1016/j.landig.2025.100907.

Mastrangelo A, Robles-Vera I, Mañanes D, Galán M, Femenía-Muiña M, Redondo-Urzainqui A, Barrero-Rodríguez R, Papaioannou E, Amores-Iniesta J, Devesa A, Lobo-González M, Carreras A, Beck KR, Ivarsson S, Gummesson A, Georgiopoulos G, Rodrigo-Tapias M, Martínez-Cano S, Fernández-López I, Nuñez V, Ferrarini A, Inohara N, Stamatelopoulos K, Benguría A, Cibrian D, Sánchez-Madrid F, Alonso-Herranz V, Dopazo A, Barbas C, Vázquez J, López JA, González-Martín A, Nuñez G, Stellos K, Bergström G, Bäckhed F, Fuster V, Ibañez B, Sancho D: Imidazole propionate is a driver and therapeutic target in atherosclerosis. Nature, 2025;645(8079):254–261, doi: 10.1038/s41586-025-09263-w.

Vlachogiannis NI, Polycarpou-Schwarz M, Avdi AP, Tual-Chalot S*, Stellos K*: Targeting RNA adenosine editing and modification enzymes for RNA therapeutics. Mol Ther, 2025;33(9):4044–4090, doi: 10.1016/j.ymthe.2025.05.021. (*equal contribution)

Mavraganis G, Georgiopoulos G, Zervas G, Aivalioti E, Delialis D, Petropoulos I, Rachiotis N, Konstantaki C, Moustou C, Dimopoulou MA, Sachse M, Tual-Chalot S, Sopova K, Psimmenou E, Stellos K*, Stamatelopoulos K*: Circulating amyloid beta 1-40 peptide as an associate of renal function decline. Eur J Clin Invest, 2025;55(5):e70006, doi: 10.1111/eci.70006. (*equal contribution)

Liberale L, Tual-Chalot S, Sedej S, Ministrini S, Georgiopoulos G, Grunewald M, Bäck M, Bochaton-Piallat ML, Boon RA, Ramos GC, de Winther MPJ, Drosatos K, Evans PC, Ferguson JF, Forslund-Startceva SK, Goettsch C, Giacca M, Haendeler J, Kallikourdis M, Ketelhuth DFJ, Koenen RR, Lacolley P, Lutgens E, Maffia P, Miwa S, Monaco C, Montecucco F, Norata GD, Osto E, Richardson GD, Riksen NP, Soehnlein O, Spyridopoulos I, Van Linthout S, Vilahur G, Wentzel JJ, Andrés V, Badimon L, Benetos A, Binder CJ, Brandes RP, Crea F, Furman D, Gorbunova V, Guzik TJ, Hill JA, Lüscher TF, Mittelbrunn M, Nencioni A, Netea MG, Passos JF, Stamatelopoulos KS, Tavernarakis N, Ungvari Z, Wu JC, Kirkland JL, Camici GG, Dimmeler S, Kroemer G, Abdellatif M, Stellos K: Roadmap for alleviating the manifestations of ageing in the cardiovascular system. Nat Rev Cardiol, 2025;22(8):577–605, doi: 10.1038/s41569-025-01130-5.

Sachse M, Stellos K: Unraveling the RNA code: a uridine RNA modification drives glycoRNA biogenesis. Signal Transduct Target Ther, 2024;9(1):334, doi: 10.1038/s41392-024-02056-z.

Aivalioti E, Georgiopoulos G, Tual-Chalot S, Bampatsias D, Delialis D, Sopova K, Drakos SG, Stellos K*, Stamatelopoulos K*: Amyloid-beta metabolism in age-related neurocardiovascular diseases. Eur Heart J, 2025;46(3):250–272, doi: 10.1093/eurheartj/ehae655. (*equal contribution)

Georgiopoulos G, Athanasopoulos S, Mavraganis G, Konstantaki C, Papaioannou M, Delialis D, Angelidakis L, Sachse M, Papoutsis D, Cavlan B, Tual-Chalot S, Zervas G, Sopova K, Mitrakou A, Stellos K*, Stamatelopoulos K*: Incremental Value of Blood-Based Markers of Liver Fibrosis in Cardiovascular Risk Stratification. J Clin Endocrinol Metab, 2025;110(4):1115–1127, doi: 10.1210/clinem/dgae619. (*equal contribution)

Wang Y, Zeller M, Auffret V, Georgiopoulos G, Räber L, Roffi M, Templin C, Muller O, Liberale L, Ministrini S, Stamatelopoulos K, Stellos K, Camici GG, Montecucco F, Rickli H, Maza M, Radovanovic D, Cottin Y, Chague F, Niederseer D, Lüscher TF, Kraler S: Sex-specific prediction of cardiogenic shock after acute coronary syndromes: the SEX-SHOCK score. Eur Heart J, 2024;45(43):4564–4578, doi: 10.1093/eurheartj/ehae593.

CRC1366

Vascular Control of Organ Function

CRC1366

Vas­cular Control of Organ Function

Vascular Control of Organ Function