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CRC1366

Vascular Control of Organ Function

Prof. Dr. Konstantinos Stellos

Department of Cardiovascular Research

European Center for Angioscience

Medical Faculty Mannheim, Heidelberg University

konstantinos.stellos(at)medma.uni-heidelberg.de

Professional Career

Since 2021

Full Professor

European Center for Angioscience

Medical Faculty Mannheim, Heidelberg University

Since 2021

Consultant Cardiologist

University Hospital Mannheim, Mannheim, Germany

2019 - 2021

Lead

Vascular Biology and Medicine, Newcastle University, UK

2018 - 2021

Hon. Consultant Cardiologist

Newcastle Hospitals NHS Foundation Trust, UK

Since 2017

Professor and Chair

Newcastle University, UK (since 09/2021 co-affiliated)

2016 - 2017

Academic Cardiologist

Goethe University Frankfurt, Germany

2012 - 2016

Group Leader

Institute of Cardiovascular Regeneration

Goethe University Frankfurt, Germany

2013 - 2014

Assistant Professor / Associate Professor

(Privatdozent / Außerplanmäßiger Professor)

Goethe University Frankfurt, Germany

2005 - 2007

MD

Experimental Medicine

University of Tübingen, Germany

Selected Publications

Vlachogiannis NI, Baker KF, Georgiopoulos G, Lazaridis C, van der Loeff IS, Hanrath AT, Sopova K, Tual-Chalot S, Gatsiou A, Spyridopoulos I, Stamatelopoulos K, Duncan CJA, Stellos K: Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study. J Cachexia Sarcopenia Muscle, 13:1502-13, 2022.

Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K: The Alzheimer's Disease amyloid-beta hypothesis in cardiovascular aging and disease: JACC focus seminar. J Am Coll Cardiol, 75:952-67, 2020.

Stamatelopoulos K, Georgiopoulos G, Athanasouli F, Nikolaou PE, Lykka M, Roussou M, Gavriatopoulou M, Laina A, Trakada G, Charakida M, Delialis D, Petropoulos I, Pamboukas C, Manios E, Karakitsou M, Papamichael C, Gatsiou A, Lambrinoudaki I, Terpos E, Stellos K*, Andreadou I*, Dimopoulos MA*, Kastritis E*: Reactive vasodilation predicts mortality in primary systemic light-chain amyloidosis. Circ Res, 125:744-58, 2019. (*equal contribution)

Stamatelopoulos K, Mueller-Hennessen M, Georgiopoulos G, Sachse M, Boeddinghaus J, Sopova K, Gatsiou A, Amrhein C, Biener M, Vafaie M, Athanasouli F, Stakos D, Pateras K, Twerenbold R, Badertscher P, Nestelberger T, Dimmeler S, Katus HA, Zeiher AM, Mueller C, Giannitsis E, Stellos K: Amyloid-β (1-40) and mortality in patients with non-ST-degment elevation acute coronary syndrome: A cohort study. Ann Intern Med, 168:855-65, 2018.

Stamatelopoulos K, Pol CJ, Ayers C, Georgiopoulos G, Gatsiou A, Brilakis ES, Khera A, Drosatos K, de Lemos JA, Stellos K: Amyloid-Beta (1-40) Peptide and subclinical cardiovascular disease. J Am Coll Cardiol, 72(9):1060-1, 2018.

Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S: Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med, 22:1140-50, 2016 .

Stamatelopoulos K, Sibbing D, Rallidis LS, Georgiopoulos G, Stakos D, Braun S, Gatsiou A, Sopova K, Kotakos C, Varounis C, Tellis CC, Kastritis E, Alevizaki M, Tselepis AD, Alexopoulos P, Laske C, Keller T, Kastrati A, Dimmeler S, Zeiher AM, Stellos K: Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease. J Am Coll Cardiol, 65:904-16, 2015.

Stellos K, Bigalke B, Borst O, Pfaff F, Elskamp A, Sachsenmaier S, Zachmann R, Stamatelopoulos K, Schönberger T, Geisler T, Langer H, Gawaz M: Circulating platelet-progenitor cell coaggregate formation is increased in patients with acute coronary syndromes and augments recruitment of CD34+ cells in the ischaemic microcirculation. Eur Heart J, 34:2548-56, 2013.

Stellos K, Bigalke B, Langer H, Geisler T, Schad A, Kögel A, Pfaff F, Stakos D, Seizer P, Müller I, Htun P, Lindemann S, Gawaz M: Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. Eur Heart J, 30:584-93, 2009.

Stellos K, Langer H, Daub K, Schoenberger T, Gauss A, Geisler T, Bigalke B, Mueller I, Schumm M, Schaefer I, Seizer P, Kraemer BF, Siegel-Axel D, May AE, Lindemann S, Gawaz M: Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells. Circulation, 117:206-15, 2008.

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