Vascular control of organ-specific inflammation in cardiometabolic diseases
Vascular endothelial dysfunction is a common hallmark of several cardiometabolic diseases including atherosclerotic cardiovascular disease, heart failure with preserved ejection fraction and non-alcoholic fatty liver disease. However, to-date, there is no treatment of cardiometabolic diseases aiming at the maintenance of vascular endothelial resilience to cardiometabolic stress by suppressing vascular, systemic and organ-specific inflammation and, ultimately, organ dysfunction. Previous own work suggests that adenosine-to-inosine RNA editing is a critical epitranscriptional regulator of pro-inflammatory gene expression in vascular endothelium. This project aims at investigating the role of the endothelial RNA editor ADAR2 in vascular endothelial cell responses to cardiometabolic pro-inflammatory stress and organ-specific inflammation.