Publications

2022

Wang Y, Elsherbiny A, Kessler L, Cordero J, Shi H, Serke H, Lityagina O, Trogisch FA, Mohammadi MM, El-Battrawy I, Backs J, Wieland T, Heineke J, Dobreva GLamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function. Nat Commun. 2022 November 4.

 

Manta CP, Leibing T, Friedrich M, Nolte H, Adrian M, Schledzewski K, Krzistetzko J, Kirkamm C, David Schmid C, Xi Y, Stojanovic A, Tonack S, de la Torre C, Hammad S, Offermanns S, Krüger M, Cerwenka A, Platten M, Goerdt S, Géraud CTargeting of scavenger receptors Stabilin-1 and Stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppression. Circulation. 2022, November 3.

Drekolia MK, Talyan S, Emídio RC, Boon RA, Guenther S, Looso M, Dumbović G and Bibli SIUnravelling the impact of aging on the human endothelial lncRNA transcriptome. Front. Genet. 2022, October 21.

Hübers C, Abdul Pari AA, Grieshober D, Petkov M, Schmidt A, Messmer T, Heyer CM, Schölch S, Kapel SS, Gengenbacher N, Singhal M, Schieb B, Fricke C, Will R, Remans K, Utikal JS, Reissfelder C, Schlesner M, Hodivala-Dilke KM, Kersten S, Goerdt S, Augustin HG, Felcht M: Primary tumor-derived systemic nANGPTL4 inhibits metastasis. J Exp Med. [Epub] 2022, October 21

Mülfarth R*, Alsina-Sanchis E*, Moll I, Böhn S, Wiedmann L, Jordana L, Ziegelbauer T, Taylor J, De Angelis Rigotti F, Stögbauer A, Giaimo BD, Cerwenka A, Borggrefe T, Fischer A*, Rodriguez-Vita J*: Endothelial Rbpj is essential for the education of tumour-associated macrophages. Cancer Res. 2022, October 6.

 

Kessler L, Gao R, Tetik-Elsherbiny N, Lityagina O, Zhailauova A, Ren Y, Trogisch FA, Cordero J, Dou Y, Wang Y, Chichelnitskiy E, Kraske JA, Schäfer PL, Wu CC, Barreto G, Potente M, Wieland T, Ola R, Heineke J, Dobreva GRnf20 shapes the endothelial control of heart morphogenesis and function. BioRxiv. 2022, September 17.

Hu J, Leisegang MS, Looso M, Dumbovic G, Wittig J, Drekolia MK, Guenther S, John D, Siragusa M, Zukunft S, Oo J, Wittig W, Hille S, Weigert A, Knapp S, Brandes RP, Mueller OJ, Papapetropoulos A, Sigala F, Dobreva G, Fleming I, Bibli SIA novel role for cystathionine gamma lyase in the control of p53: impact on endothelial senescence and metabolic reprograming. BioRxiv. 2022, September 5.

 

Cheng S, Mittnenzweig M, Mayshar Y, Lifshitz A, Dunjic M, Rais Y, Ben-Yair R, Gehrs S, Chomsky E, Mukamel Z, Schlereth K, Reines N, Orenbuch AH, Tanay A, Stelzer Y: The intrinsic and extrinsic effects of Tet proteins during gastrulation. Cell. 2022, August 18.

Gehrs S, Jakab M, Gutjahr E, Gu Z, Weichenhan D, Mogler C, Schlesner M, Plass C, Augustin HG, Schlereth KEndothelial Dnmt3a controls placenta vascularization and function to support fetal growth. BioRxiv. 2022, July 29.

Papaioannou S#, See J-X#, Jeong M, De La Torre C, Reiners-Koch PS, Batra A, Mogler C, Platten M, Cerwenka A*, Stojanovic A*: Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury. BioRxiv. 2022, July 16.

Tulessin M, Sarker RSJ, Griger J, Leibing T, Géraud C, Weichert W, Steiger K, Mogler CVascular remodeling is a crucial event in the early phase of hepatocarcinogenesis in rodent models for liver tumorigenesis. Cells. 2022, July 6.

Banerjee K, Gahn J, Lin Y, Lei X, Gupta P, Graupera M, Schwartz MA, Ola RShear stress induced KLF4 is a key determinant in AVM pathogenesis. BioRxiv. 2022, July 4.

Sahm K, Kessler T, Eisele P, Ratliff M, Sperk E, Koenig L, Breckwoldt M, Seliger C, Mildenberger I, Schrimpf D, Herold-Mende C, Zeiner P, Tabatabai G, Meuth S, Capper D, Bendszus M, von Deimling A, Wick W, Sahm F, Platten M: Concurrent gliomas in patients with multiple sclerosis. MedRxiv. 2022, July 4.

Schmid CD*, Olsavszky V*, Reinhart M*, Weyer V, Trogisch FA, Sticht C, Winkler M, Kürschner SW, Hoffmann J, Ola R, Staniczek T, Heineke J, Straub BK, Mittler J, Schledzewski K, ten Dijke P, Dooley S, Géraud C, Goerdt S*, Koch PS*: ALK1 controls hepatic vessel formation, angiodiversity, and angio-crine functions in hereditary hemorrhagic telangiectasia of the liver. Hepatology. 2022, July 1.

Manta CP*, Leibing T*, Friedrich M, Nolte H, Adrian M, Schledzewski K, Krzistetzko J, Kirkamm C, Schmid CD, Xi Y, Stojanovic A, Tonack S, de la Torre C, Hammad S, Offermanns S, Krüger M, Cerwenka A, Platten M, Goerdt S#, Géraud C#: Targeting of scavenger receptors Stabilin-1 and Stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppression. BioRxiv. 2022, July 1.

Jakab M*, Lee KH*, Uvarovskii A, Ovchinnikova S, Kulkarni S, Rostalski T, Anders S, Augustin HGLung endothelium instructs dormancy of susceptible metastatic tumor cells. BioRxiv. 2022, June 19.

Jeong HW, Dieguez-Hurtado R, Arf H, Song J, Park H, Kruse K, Sorokin L, Adams RHSingle cell transcriptomics reveals functionally specialized vascular endothelium in brain. BioRxiv. 2022, June 13.

Garcés-Lázaro I, Kotzur R, Cerwenka A*, Mandelboim O*: NK cells under hypoxia: The two faces of vascularization in tumor and pregnancy. Front Immunol. 2022, June 13.

Kilian M, Sheinin R, Tan CL, Krämer C, Friedrich M, Kaminitz A, Sanghvi K, Lindner K, Cichon F, Jung S, Jähne K, Ratliff M, Prins R, von Deimling A, Wick W, Madi A, Bunse L, Platten MMHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors. BioRxiv. 2022, June 12.

Tisch N, Mogler C, Stojanovic A, Luck R, Korhonen EA, Ellerkmann A, Adler H, Schermann G, Erkert L, Patankar JV, Karakatsani A, Scherr AL, Fuchs Y, Cerwenka A, Wirtz S, Köhler BC, Augustin HG, Becker C, Schmidt T, Ruiz de Almodovar CCaspase-8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice. EMBO Mol Med. 2022, June 8.

S Ovchinnikova, S AndersR/LinkedCharts: A novel approach for simple but powerful interactive data analysis. BioRxiv. 2022, June 1.

Friedrich M, Hahn M, Michel J, Sankowski R, Kilian M, Kehl N, Günter M, Bunse T, Pusch S, von Deimling A, Wick W, Autenrieth SE, Prinz M, Platten M, Bunse L: Dysfunctional dendritic cells limit antigen-specific T cell response in gliomaNeuro-Oncol. 2022, May 24.

Jakab M, Rostalski T, Lee KH, Mogler C, Augustin HG: Tie2 receptor in tumor-infiltrating macrophages is dispensable for tumor angiogenesis and tumor relapse after chemotherapy. Cancer Res. 2022, April 1.

El-Sammak H, Yang B, Guenther S, Chen W, Marín-Juez R, Stainier DYRA Vegfc-Emilin2a-Cxcl8a signaling axis required for zebrafish cardiac regeneration. Circ Res. 2022, March 10.

Coxam B, Collins RT, Hussmann M, Huisman Y, Meier K, Jung S, Bartels-Klein E, Szymborska A, Finotto A, Helker CSM, Stainier DYR, Schulte-Merker S, Gerhardt HSvep1 stabilises developmental vascular anastomosis in reduced flow conditions. Development. 2022, March 15.

Liu Y, Chen Q, Jeong HW, Koh BI, Watson EC, Xu C, Stehling M, Zhou B, Adams RHA specialized bone marrow microenvironment for fetal haematopoiesis. Nat Commun. 2022, March 14.

Siegler J-J, Correia MP, Hofman T, Prager I, Birgin E, Rahbari NN, Watzl C, Stojanovic A*, Cerwenka A*: Human ILC3 exert TRAIL-mediated cytotoxicity towards cancer cells. Front Immunol. 2022, March 1.

Froese N, Cordero J, Abouissa A, Trogisch FA, Grein S, Szaroszyk M, Wang Y, Gigina A, Korf-Klingebiel M, Bosnjak B, Davenport CF, Wiehlmann, L, Geffers R, Riechert E, Jürgensen L, Boileau E, Lin Y, Dieterich C, Förster R, Bauersachs J, Ola R, Dobreva G*, Völkers M*, Heineke J*: Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional inter-cellular communication. iScience. 2022, February 23.

Weis EM, Puchalska P, Nelson AB, Taylor J, Moll I, Hasan SS, Dewenter M, Hagenmüller M, Fleming T, Poschet G, Hotz-Wagenblatt A, Backs J, Crawford PA, Fischer AKetone body oxidation increases cardiac endothelial cell proliferation. 

EMBO Mol Med. 2022, February 18.

Nicin L, Schroeter SM, Glaser S, Schulze-Brüning R, Pham M-D, Hille SS, Yekelchyk M, Badder K, Abplanalp WT, Tombor L, Müller OJ, Baun T, Meder B, Reich C, Arsalan M, Holubec T, Walther T, Emrich F, Krishnan J, Zeiher AM, John D, Dimmeler SA human cell atlas of the pressure-induced hypertrophic heart. Nat Cardiovasc Res. 2022, February 14.

Xu C, Dinh VV, Kruse K, Jeong HW, Watson EC, Adams S, Berkenfeld F, Stehling M, Rasouli SJ, Fan R, Chen R, Bedzhov I, Chen Q, Kato K, Pitulescu ME, Adams RHInduction of osteogenesis by bone-targeted Notch activation. eLife. 2022, February 4.

Wohlfeil SA, Häfele V, Dietsch B, Weller C, Sticht C, Jauch AS, Winkler M, Schmid CD, Irkens AL, Olsavszky A, Schledzewski K, Reiners-Koch PS, Goerdt S & Géraud CAngiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment. J Transl Med. 2022, February 2.

Sivaraj KK, Majev PG, Jeong HW, Dharmalingam B, Zeuschner D, Schröder S, Bixel MG, Timmen M, Stange R, Adams RHMesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing. Nat Commun. 2022, January 28.

Szaroszyk M, Kattih B, Martin-Garrido A, Trogisch FA, Dittrich GM, Grund G, Abouissa A, Derlin K, Meier M, Holler T, Korf-Klingebiel M, Völker K, Macedo TG, Tortola CP, Boschmann M, Huang N, Froese N, Zwadlo C, Malek Mohammadi M, Luo X, Wagner M, Cordero J, Geffers R, Batkai S, Thum T, Bork N, Nikolaev VO, Müller OJ, Katus HA, El-Amouche A, Kraft T, Springer J, Dobreva G, Wollert KC, Fielitz J, von Haehling S, Kuhn M, Bauersachs J, Heineke JSkeletal muscle derived Musclin protects the heart during pathological overload. Nat Commun. 2022, January 10.

2021

Shen Y, Wang X, Liu Y, Singhal M, Gürkaslar C, Freire Valls A, Lei Y, Hu W, Schermann G, Adler H, Yu FX, Fischer T, Zhu Y, Augustin HG, Schmidt T, Ruiz de Almodovar C: STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis. Sci Signal. 2021, December 7.

Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS: Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun. 2021 November 29.

Cai C, Itzel T, Gaitantzi H, de la Torre C, Birgin E, Betge J, Gretz N, Teufel A, Rahbari NN, Ebert MP, Breitkopf-Heinlein K: Identification of liver-derived bone morphogenetic protein (BMP)-9 as a potential new candidate for treatment of colorectal cancer. J Cell Mol Med. 2021 November 28.

 

Laban H, Siegmund S, Zappe M, Trogisch FA, Heineke J, Torre C, Fisslthaler B, Arnold C, Lauryn J, Büttner M, Mogler C, Kato K, Adams RH, Kuk H, Fischer A, Hecker M, Kuebler WM, Korff T: TNFAT5/TonEBP limits pulmonary vascular resistance in the hypoxic lung by controlling mitochondrial reactive oxygen species generation in arterial smooth muscle cells. Cells. 2021, November 24.

Wagner JUG, Dimmeler S: The endothelial niche in heart failure: From development to regeneration. Eur Heart J. 2021, November 1.

Friedrich M, Sankowski R, Bunse L, Kilian M, Green E, Ramallo Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Gegner HM, Sonner JK, von Landenberg A, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland DH, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana FJ, von Deimling A, Wick W, Prinz M, Platten M: Tryptophan metabolism drives dynamic immune-suppressive myeloid states in IDH-mutant gliomas. Nat Cancer. 2021, May 24.

Stojanovic A, Cerwenka A: ILC1-like NK cells as matchmakers for DC-T cell interactions. Immunity. 2021, October 12.

Koch PS*, Sandorski K*, Heil J, Schmid CD, Kürschner SW, Hoffmann J, Winkler M, Staniczek T, De La Torre C, Sticht C, Schledzewski K, Taketo MM, Trogisch F, Heineke J, Géraud C, Goerdt S, Olsavszky V: Imbalanced activation of Wnt-/β-catenin-signaling in liver endothelium alters normal sinusoidal differentiation. Front Physiol. 2021, September 29.

Schott J, Reitter S, Lindner D, Grosser J, Bruer M, Shenoy A, Geiger T, Mathes A, Dobreva G, Stoecklin G: Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density. Nat Methods. 2021, September 3.

Singhal M*, Gengenbacher N*, Abdul Pari AA*, Kamiyama M, Hai L, Kuhn BJ, Kallenberg DM, Kulkarni SR, Camilli C, Preuß SF, Leuchs B, Mogler C, Espinet E, Besemfelder E, Heide D, Heikenwalder M, Sprick MR, Trumpp A, Krijgsveld J, Schlesner M, Hu J, Moss SE, Greenwood J, Augustin HG: Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. Sci. Transl. Med. 2021, September 1.

Stojanovic A, Cerwenka AAn intimate encounter: DC3s empower anti-tumor CTLs. Cancer Cell. 2021, August 19.

Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D'Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodovar C:

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep. 2021, August 17.

Kappert L, Ruzicka P, Kutikhin A, De La Torre C, Fischer A, Hecker M, Arnold C, Korff TLoss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells. FASEB J. 2021, August 12.

Jing Y, Ren Y, Witzel HR, Dobreva G: A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis. Stem Cell Reports. 2021, August 10.

Bibli SI, Fleming IOxidative post translational modifications: a focus on cysteine S-sulfhydration and the regulation of endothelial fitness. Antioxid Redox Signal. 2021, August 4.

Lityagina O, Dobreva G: The LINC between mechanical forces and chromatin. Front Physiol. 2021, August 2.

Sivaraj KK, Jeong HW, Dharmalingam B, Zeuschner D, Adams S, Potente M, Adams RH: Regional specialization and fate specification of bone stromal cells in skeletal development. Cell Rep. 2021, July 13.

Alsina-Sanchis E, Mülfarth R, Fischer A: Control of tumor progression by angiocrine factors. Cancers. 2021 May 26.

Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Argos Vélez P, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S and Augustin HG: A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver. Developmental Cell. 2021, May 25.

 

Zhang XW, Huck K, Jähne K, Cichon F, Sonner JK, Ufer F, Bauer S, Woo MS, Green E, Lu K, Kilian M, Friese MA, Platten M and Sahm K: Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma. Oncoimmunology. 2021, May 14.

Jiang X, Hu J, Wu Z, Cafarello ST, Di Matteo M, Shen Y, Dong X, Adler H, Mazzone M, Ruiz de Almodóvar C and Wang X: Protein Phosphatase 2A mediates YAP activation in endothelial cells upon VEGF stimulation and matrix stiffness.

Front. Cell Dev. Biol. 2021, May 13.

Nicin L, Abplanalp WT, Schänzer A, Sprengel A, John D, Mellentin H, Tombor L, Keuper M, Ullrich E, Klingel K, Dettmeyer RB, Hoffmann J, Akintuerk H, Jux C, Schranz D, Zeiher AM, Rupp S, Dimmeler S: Single nuclei sequencing reveals novel insights into the regulation of cellular signatures in children with dilated cardiomyopathy. Circulation. 2021, April 27.

Dittrich GM, Froese N, Wang X, Kroeger H, Wang H, Szaroszyk M, Malek-Mohammadi M, Cordero J, Keles M, Korf-Klingebiel M, Wollert KC, Geffers R, Mayr M, Conway SJ, Dobreva G, Bauersachs J, Heineke J: Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesisBasic Res Cardiol. 2021 April 19.

Tsedeke AT, Allanki S, Gentile A, Jimenez-Amilburu V, Rasouli SJ, Guenther S, Lai SL, Stainier DYR, Marín-Juez R: Cardiomyocyte heterogeneity during zebrafish development and regeneration. Dev Biol. 2021, April 12.

Elsherbiny A, Dobreva GEpigenetic memory of cell fate commitment. Curr Opin Cell Biol. 2021, April 2021.

Tisch N & Ruiz de Almodóvar CContribution of cell death signaling to blood vessel formation. Cell Mol Life Sci​. 2021 Mar 30.

 

Weber P, Baltus D, Jatho A, Drews O, Zelarayan LC, Wieland T & Lutz S: RhoGEF17 – An essential regulator of endothelial cell death and growth. Cells. 2021, March 27.

 

Koch PS*, Lee KH*, Goerdt S, Augustin HGAngiodiversity and organotypic functions of sinusoidal endothelial cells. Angiogenesis. 2021, March 21.

 

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia M-K, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Lagos FD, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming IMapping the endothelial cell S-sulfhydrome highlights the crucial role of integrin sulfhydration in vascular function. Circulation. 2021, March 2.

Luxán G, Dimmeler S: The vasculature: a therapeutic target in heart failure? Cardiovasc Res. 2021, February 23.

Kohlhaas J, Jäger MA, Lust L, De La Torre C, Hecker M, Korff T: Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Exp Cell Res. 2021, February 15.

Olsavszky V, Sticht C, Schmid CD, Winkler M, Wohlfeil SA, Olsavszky A, Schledzewski K, Géraud C, Goerdt S, Leibing T, Koch PSExploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells. Gene. 2021, February 5.

Alsina-Sanchis E, Mülfarth R, Moll I, Mogler C, Rodriguez-Vita J and Fischer AIntraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages. Mol Cancer Res. 2021, February 3.

Gengenbacher N*, Singhal M*, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HGTimed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov. 2021, February 2.

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang X, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Reiners-Koch PS, Goerdt SEndothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 2021, February.

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT & Dimmeler SSingle cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun. 2021, January 29.

Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG & Ruiz de Almodóvar COligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk. Nat Neurosci. 2021, January 28.

Morgenstern J, Fleming T, Kliemanek E, Brune M, Nawroth PP, Fischer AQuantification of all-trans retinoic acid by liquid chromatography-tandem mass spectrometry and association with lipid profile in patients with type 2 diabetes. Metabolites. 2021, January 19.

Abdul Pari AA, Singhal M, Augustin HGEmerging paradigms in metastasis research. J Exp Med. 2021, January 4.

Hasan SS, Fischer AThe Endothelium: An active regulator of lipid and glucose homeostasis. Trends Cell Biol. 2021, January.

Attarwala A, Hardiansyah D, Romanó C, Jiménez-Franco LD, Roscher M, Wängler B, Glatting, G: Performance assessment of the ALBIRA II pre‑clinical SPECT S102 system for 99mTc imaging. Ann Nucl Med. 2021, January.

 
2020

Vieira JR, Shah B, Ruiz de Almodovar C: Cellular and molecular mechanisms of spinal cord vascularization. Front Physiol. 11:599897, 2020, December 21.

Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J: Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.

Cell Rep. 2020, October 13.

 

Wu CC, Jeratsch S, Graumann J, Stainier DYR: Modulation of mammalian cardiomyocyte cytokinesis by the extracellular matrix. Circ Res. 127:896-907, 2020, September 11.

Steiger K, Gross N, Widholz SA, Rad R, Weichert W, Mogler C: Genetically Engineered Mouse Models of Liver Tumorigenesis Reveal a Wide Histological Spectrum of Neoplastic and Non-Neoplastic Liver Lesions. Cancers. 2020, August 13.

Jakab M, Augustin HG: Understanding angiodiversity: insights from single cell biology. Development. 2020, August 12.

 

Fukuda R, Marín-Juez R*, El-Sammak H*, Beisaw A, Ramadass R, Kuenne C, Guenther S, Konzer A, Bhagwat AM, Graumann J, Stainier DY: Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO Rep. 2020, July 9.

 

Roider T, Seufert J, Uvarovskii A, Frauhammer F, Bordas M, Abedpour N, Stolarczyk M, Mallm J-P, Herbst SA, Bruch P-M, Balke-Want H, Hundemer M, Rippe K, Goeppert B, Seiffert M, Brors B, Mechtersheimer G, Zenz T, Peifer M, Chapuy B, Schlesner M, Müller-Tidow C, Fröhling S, Huber W, Anders S*, Dietrich S*: Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level. Nature Cell Biology. 2020, June 15.

 

Abdul Pari AA*, Singhal M*, Hübers C, Mogler C, Schieb B, Gampp A, Gengenbacher N, Reynolds LE, Terhardt D, Géraud C, Utikal J, Thomas M, Goerdt S, Hodivala-Dilke K, Augustin HG# , Felcht M#: Tumor cell-derived Angiopoietin-2 promotes melanoma metastasis. Cancer Res. 80:2586-98, 2020, June 15.

Shen Y, Wang X, Lu J, Salfenmoser M, Wirsik NM, Schleussner N, Imle A, Freire Valls A, Radhakrishnan P, Liang J, Wang G, Muley T, Schneider M, Ruiz de Almodovar C, Diz-Muñoz A, Schmidt T: Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer. Cancer Cell. 2020, June 8.

 

Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A: Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. Immunity. 2020, May 22.

 

Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar Š, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M: Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells. Nat Immunol. 2020, May 18.

 

Ovchinnikova S, Simon A: Exploring Dimension-Reduced Embeddings With Sleepwalk. Genome Res. 30:749-56, 2020, May 18.

Nicin L, Abplanalp WT, Mellentin H, Kattih B, Tombor L, John D, Schmitto JD, Heineke J, Emrich F, Arsalan M, Holubec T, Walther T, Zeiher AM, Dimmeler S: Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts. Eur Heart J, 41:1804-6. 2020, May 14.

Singhal M, Gengenbacher N, La Porta S, Gehrs S, Shi J, Kamiyama M, Bodenmiller DM, Fischl A, Schieb B, Besemfelder E, Chintharlapalli S, Augustin HG: Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking antibody. EMBO Mol Med. 2020, April 17.

Hasan* SS, Jabs M*, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne H-J, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer AEndothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med. 2020, March 18.

Gaitantzi H, Karch J, Germann L, Cai C, Rausch V, Birgin E, Rahbari N, Seitz T, Hellerbrand C, König C, Augustin HG, Mogler C, de la Torre C, Gretz N, Itzel T, Teufel A, Ebert MPA, Breitkopf-Heinlein K: BMP-9 Modulates the Hepatic Responses to LPS. Cells. 2020, March 4.

 

Jäger MA, De La Torre C, Arnold C, Kohlhaas J, Kappert L, Hecker M, Feldner A, Korff TAssembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res. 2020, March 1.​

Aslan K, Turco V, Blobner J, Sonner JK, Liuzzi AR, Núñez NG, De Feo D, Kickingereder P, Fischer M, Green E, Sadik A, Friedrich M, Sanghvi K, Kilian M, Cichon F, Wolf L, Jähne K, von Landenberg A, Bunse L, Sahm F, Schrimpf D, Meyer J, Alexander A, Brugnara G, Röth R, Pfleiderer K, Niesler B, von Deimling A, Opitz C, Breckwoldt MO, Heiland S, Bendszus M, Wick W, Becher B, Platten M: Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas. Nat Commun. 2020, February 18.

Singhal M, Augustin HG: Beyond Angiogenesis: Exploiting Angiocrine Factors to Restrict Tumor Progression and Metastasis. Cancer Res. 2020, February 15.

Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. Proc Natl Acad Sci U S A. 2020, February 7.

Zhang XJ, Olsavszky V, Yin Y, Wang B, Engleitner T, Öllinger R, Schledzewski K, Koch PS, Rad R, Schmid RM, Friess H, Goerdt S, Hüser N, Géraud C, von Figura G, Hartmann D: Angiocrine Hepatocyte Growth Factor Signaling Controls Physiological Organ and Body Size and Dynamic Hepatocyte Proliferation to Prevent Liver Damage during Regeneration. Am J Pathol. 2020, February.

Dropmann A, Dooley S, Dewidar B, Hammad S, Dediulia T, Werle J, Hartwig V, Ghafoory S, Woelfl S, Korhonen H, Janicot M, Wosikowski K, Itzel T, Teufel A, Schuppan D, Stojanovic A, Cerwenka A, Nittka S, Piiper A, Gaiser T, Beraza N, Milkiewicz M, Milkiewicz P, Brain JG, Jones DEJ, Weiss TS, Zanger UM, Ebert M, Meindl-Beinker NM: TGF-β2 silencing to target biliary-derived liver diseases. Gut, 69:1677-90, 2020, January 21.

Sivaraj KK, Dharmalingam B, Mohanakrishnan V, Jeong HW, Kato K, Schröder S, Adams S, Koh GY, Adams RH: YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. eLife, 9:e50770, 2020, January 20.

Bibli SI, Hu J, Leisegang MS, Wittig J, Zukunft S, Kapasakalidi A, Fisslthaler B, Tsilimigras D, Zografos G, Filis K, Brandes RP, Papapetropoulos A, Sigala F, Fleming IShear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation. Redox Biol. 2020, January 28.

Wagner JUG, Dimmeler S: Cellular cross-talks in the diseased and aging heart. J Mol Cell Cardiol. 138:136–46, 2020, January.

Wagner JUG, Pham MD, Nicin L, Hammer M, Bottermann K, Yuan T, Sharma R, John D, Muhly-Reinholz M, Tombor L, Hardt M, Madl J, Dimmeler S, Krishnan J: Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics. J Mol Cell Cardiol. 2020, January.

 
2019

Luck R*, Urban S*, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, Ruiz de Almodóvar CVEGF/VEGFR2 signaling regulates hippocampal axon branching during development. elife. 2019, December 23.

Chen Q, Liu Y, Jeong HW, Stehling M, Dinh VV, Zhou B, Adams RHApelin+ endothelial niche cells control hematopoiesis and mediate vascular regeneration after myeloablative injury. Cell Stem Cell, 2019, December 5.

Klose R, Prinz A, Tetzlaff F, Weis EM, Moll I, Rodriguez-Vita J, Oka C, Korff T, Fischer A: Loss of the serine protease HTRA1 impairs smooth muscle cells maturation. Scientific Reports. 2019, December 3.

Tisch N, Freire-Valls A, Yerbes R, Paredes I, La Porta S, Wang X, Martín-Pérez R, Castro L, Wong WW, Coultas L, Strilic B, Gröne HJ, Hielscher T, Mogler CAdams RH, Heiduschka P, Claesson-Welsh L, Mazzone M, López-Rivas A, Schmidt T, Augustin HGRuiz de Almodovar CCaspase-8 modulates physiological and pathological angiogenesis during retina development. J Clin Invest. 2019, December 2.

Park H, Yamamoto H, Mohn L, Ambühl L, Kanai L, Schmidt I, Kim KP, Fraccaroli A, Feil S, Junge HJ, Montanez E, Berger W* & Adams R*: Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat Commun. 2019, November 20.

Marín-Juez R, El-Sammak H, Helker CSM,  Kamezaki A, Mullapuli ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR: Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Dev Cell. 2019, November 18.

Vidal R, Wagner JUG, Braeuning C, Fischer C, Patrick R, Tombor L, Muhly-Reinholz M, John D, Kliem M, Conrad T, Guimarães-Camboa N, Harvey R, Dimmeler S, Sauer S: Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart. JCI Insight. 2019, November 14.

 

Collins MM, Ahlberg G, Hansen CV, Guenther S, Marín-Juez R, Sokol AM, El-Sammak H, Piesker J, Hellsten Y, Olesen MS, Stainier DYR: Lundegaard PR: Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model. Proc Natl Acad Sci U S A. 2019, November 8.

 

Gancz D, Raftrey BC, Perlmoter G, Marín-Juez R, Semo J, Matsuoka RL, Karra R, Raviv H, Moshe N, Addadi Y, Golani O, Poss KD, Red-Horse K, Stainier DY, Yaniv K: Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. elife. 2019, November 8.

Freire Valls A*, Knipper K*, Giannakouri E, Sarachaga V, Hinterkopf S, Wuehrl M, Shen Y, Radhakrishnan P, Klose J, Ulrich A, Schneider M, Augustin HGRuiz de Almodovar C, Schmidt T: VEGFR1+ Metastasis-Associated Macrophages Contribute to Metastatic Angiogenesis and Influence Colorectal Cancer Patient Outcome. Clin Cancer Res. 2019, September 15.

Malek Mohammadi M, Abouissa A, Azizah I, Xie Y, Cordero J, Shirvani A, Gigina A, Engelhardt M, Trogisch FA, Geffers R, Dobreva G, Bauersachs J, Heineke JInduction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation. JCI Insight. 2019, July 23.

Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, Silva K de, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming INitric oxide maintains endothelial redox homeostasis through PKM2 inhibition. EMBO J. 2019, July 22.

Scharf GM, Kilian K, Cordero J, Wang Y, Grund A, Hofmann M, Froese N, Wang X, Kispert A, Kist R, Conway SJ, Geffers R, Wollert KC, Dobreva G, Bauersachs J, Heineke JInactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation. JCI Insight. 2019, July 16.

Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva GPioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res. 2019, June.

Schreiber C, Saraswati S, Harkins S, Gruber A, Cremers N, Thiele W, Rothley M, Plaumann D, Korn C, Armant O, Augustin HG, Sleeman JP: Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling. PLoS Genet. 2019, June 27.

Lai SL, Marín-Juez RStainier DYR: Immune responses in cardiac repair and regeneration: a comparative point of view. 

Cell Mol Life Sci. 2019, April 15.

Karakatsani A, Shah B, Ruiz de Almodovar CBlood vessels as regulators of neural stem cell properties. Front Mol Neurosci. 2019, April 12. 

Wohlfeil SA*, Häfele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Mohammadi MM, Heineke J, Sticht C, Olsavszky V, Koch PS, Géraud C*, Goerdt S*: Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res. 2019, February 1.

Bibli SI*, Hu J*, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras D, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis K, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming ICystathionine γ lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherogenesis. Circulation. 2019, January 2.

Grund A, Szaroszyk M, Doppner JK, Malek Mohammadi M, Kattih B, Korf-Klingebiel M, Gigina A, Scherr M, Kensah G, Jara-Avaca M, Gruh I, Martin U, Wollert KC, Gohla A, Katus HA, Muller OJ, Bauersachs J, Heineke JA gene therapeutic approach to inhibit calcium and integrin binding protein 1 ameliorates maladaptive remodelling in pressure overload. Cardiovasc Res. 2019, January 1.

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Contact

Spokesperson

Prof. Dr. Hellmut G. Augustin

European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg

Vice Spokesperson

Prof. Dr. Sergij Goerdt

University Hospital for Dermatology,

Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim, Heidelberg University