PUBLICATIONS

2022

Jakab M, Rostalski T, Lee KH, Mogler C, Augustin HG: Tie2 receptor in tumor-infiltrating macrophages is dispensable for tumor angiogenesis and tumor relapse after chemotherapy. Cancer Res. 2022 Apr 1.

El-Sammak H, Yang B, Guenther S, Chen W, Marín-Juez R, Stainier DYR: A Vegfc-Emilin2a-Cxcl8a signaling axis required for zebrafish cardiac regeneration. Circ Res. 2022 March 10.

Weis EM, Puchalska P, Nelson AB, Taylor J, Moll I, Hasan SS, Dewenter M, Hagenmüller M, Fleming T, Poschet G, Hotz-Wagenblatt A, Backs J, Crawford PA, Fischer A: Ketone body oxidation increases cardiac endothelial cell proliferation.

EMBO Mol Med, 2022 February 18.

Wohlfeil SA, Häfele V, Dietsch B, Weller C, Sticht C, Jauch AS, Winkler M, Schmid CD, Irkens AL, Olsavszky A, Schledzewski K, Reiners-Koch PS, Goerdt S & Géraud C: Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment. J Transl Med, 2022 February 2.

Sivaraj KK, Majev PG, Jeong HW, Dharmalingam B, Zeuschner D, Schröder S, Bixel MG, Timmen M, Stange R, Adams RH: Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing. Nat Commun. 2022 January 28.

2021

Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS: Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun. 2021 November 29.

Cai C, Itzel T, Gaitantzi H, de la Torre C, Birgin E, Betge J, Gretz N, Teufel A, Rahbari NN, Ebert MP, Breitkopf-Heinlein K: Identification of liver-derived bone morphogenetic protein (BMP)-9 as a potential new candidate for treatment of colorectal cancer. J Cell Mol Med. 2021 November 28.

Singhal M*, Gengenbacher N*, Abdul Pari AA*, Kamiyama M, Hai L, Kuhn BJ, Kallenberg DM, Kulkarni SR, Camilli C, Preuß SF, Leuchs B, Mogler C, Espinet E, Besemfelder E, Heide D, Heikenwalder M, Sprick MR, Trumpp A, Krijgsveld J, Schlesner M, Hu J, Moss SE, Greenwood J, Augustin HG: Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. Sci. Transl. Med. 2021 September 1.

Stojanovic A, Cerwenka A: An intimate encounter: DC3s empower anti-tumor CTLs. Cancer Cell. 2021 August 19.

Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong H-W, Back MK, Hetsch F, D’Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodóvar C: The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell reports. 2021 August 17.

Kappert L, Ruzicka P, Kutikhin A, De La Torre C, Fischer A, Hecker M, Arnold C, Korff T: Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells. FASEB J. 2021 August 12.

Jing Y, Ren Y, Witzel HR, Dobreva G: A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis. Stem Cell Reports. 2021 Aug 10

Lityagina O, Dobreva G: The LINC between mechanical forces and chromatin. Front Physiol. 2021 Aug 2

Bibli SI, Fleming I: Oxidative post translational modifications: a focus on cysteine S-sulfhydration and the regulation of endothelial fitness. Antioxid Redox Signal. 2021 August 4.

Alsina-Sanchis E, Mülfarth R, Fischer A: Control of tumor progression by angiocrine factors. Cancers. 2021 May 26.

Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Argos Vélez P, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S and Augustin HG: A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver. Developmental Cell. May 25, 2021.

Zhang XW, Huck K, Jähne K, Cichon F, Sonner JK, Ufer F, Bauer S, Woo MS, Green E, Lu K, Kilian M, Friese MA, Platten M and Sahm K: Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma. Oncoimmunology. 2021 May 14.

Jiang X, Hu J, Wu Z, Cafarello ST, Di Matteo M, Shen Y, Dong X, Adler H, Mazzone M, Ruiz de Almodóvar C and Wang X: Protein Phosphatase 2A mediates YAP activation in endothelial cells upon VEGF stimulation and matrix stiffness.

Front. Cell Dev. Biol. 2021 May 13.

Tsedeke AT, Allanki S, Gentile A, Jimenez-Amilburu V, Rasouli SJ, Guenther S, Lai SL, Stainier DYR, Marín-Juez R: Cardiomyocyte heterogeneity during zebrafish development and regeneration. Dev Biol. 2021 Apr 12.

Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W: A vaccine targeting mutant IDH1 in newly diagnosed glioma. Nature. 592:463-468, 2021 March 24.

Koch PS, Lee KH, Goerdt S & Augustin HG: Angiodiversity and organotypic functions of sinusoidal endothelial cells. Angiogenesis. 2021 March 21

Dittrich GM, Froese N, Wang X, Kroeger H, Wang H, Szaroszyk M, Malek-Mohammadi M, Cordero J, Keles M, Korf-Klingebiel M, Wollert KC, Geffers R, Mayr M, Conway SJ, Dobreva G, Bauersachs J, Heineke J: Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis.

Basic Res Cardiol. 2021 Apr 19.

Tisch N & Ruiz de Almodóvar C: Contribution of cell death signaling to blood vessel formation.

Cell Mol Life Sci. 2021 Mar 30.

Weber P, Baltus D, Jatho A, Drews O, Zelarayan LC, Wieland T & Lutz S: RhoGEF17 – An essential regulator of endothelial cell death and growth. Cells, 2021 Mar 27.

Luxán G, Dimmeler S: The vasculature: a therapeutic target in heart failure? Cardiovasc Res. 2021 February 23

Kohlhaas J, Jäger MA, Lust L, De La Torre C, Hecker M, Korff T: Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Exp Cell Res. 2021 February 15

Olsavszky V, Sticht C, Schmid CD, Winkler M, Wohlfeil SA, Olsavszky A, Schledzewski K, Géraud C, Goerdt S, Leibing T, Koch PS: Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells. Gene. 2021 February 5

Alsina-Sanchis E, Mülfarth R, Moll I, Mogler C, Rodriguez-Vita J and Fischer A: Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages. Mol Cancer Res. 2021 February

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT & Dimmeler S: Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun., 2021 Jan 29

Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG & Ruiz de Almodóvar C: Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk. Nat Neurosci., 2021 Jan 28

Abdul Pari AA, Singhal M, Augustin HG: Emerging paradigms in metastasis research. J Exp Med., 2021 Jan 4

Elsherbiny A, Dobreva G: Epigenetic memory of cell fate commitment. Curr Opin Cell Biol. 2021 January 2021

2020

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I: Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function.

Circulation, 2020 Dec 14

Gengenbacher N*, Singhal M*, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Fricke F, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli S, Augustin HG: Timed Ang2-targeted therapy 1 identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis.
Cancer Discovery 2020 Oct 26

Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J: Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.

Cell Rep., 2020 Oct 13

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S: Endothelial GATA4 controls liverfibrosis and regeneration bypreventing a pathogenic switch in angiocrine signaling. Journal of Hepatology, 2020 Sep 9

Jakab M, Augustin HG: Understanding angiodiversity: insights from single cell biology. Development. 2020 Aug 12

Steiger K, Gross N, Widholz SA, Rad R, Weichert W, Mogler C: Genetically Engineered Mouse Models of Liver Tumorigenesis Reveal a Wide Histological Spectrum of Neoplastic and Non-Neoplastic Liver Lesions. Cancers., 2020 Aug 13

Fukuda R, Marín-Juez R*, El-Sammak H*, Beisaw A, Ramadass R, Kuenne C, Guenther S, Konzer A, Bhagwat AM, Graumann J, Stainier DY: Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO Rep., 2020 Jul 9

Roider T, Seufert J, Uvarovskii A, Frauhammer F, Bordas M, Abedpour N, Stolarczyk M, Mallm J-P, Herbst SA, Bruch P-M, Balke-Want H, Hundemer M, Rippe K, Goeppert B, Seiffert M, Brors B, Mechtersheimer G, Zenz T, Peifer M, Chapuy B, Schlesner M, Müller-Tidow C, Fröhling S, Huber W, Anders S*, Dietrich S*: Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level. Nature Cell Biology. 2020 June 15

Shen Y, Wang X, Lu J, Salfenmoser M, Wirsik NM, Schleussner N, Imle A, Freire Valls A, Radhakrishnan P, Liang J, Wang G, Muley T, Schneider M, Ruiz de Almodovar C, Diz-Muñoz A, Schmidt T: Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer. Cancer Cell. 2020 June 8

Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A: Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. Immunity. 2020 May 22

Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar Š, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M: Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells. Nat Immunol. 2020 May 18

Ovchinnikova S, Simon A: Exploring Dimension-Reduced Embeddings With Sleepwalk. Genome Res. Epub 2020 May 19.

Singhal M, Gengenbacher N, La Porta S, Gehrs S, Shi J, Kamiyama M, Bodenmiller DM, Fischl A, Schieb B, Besemfelder E, Chintharlapalli S, Augustin HG: Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking antibody. EMBO Mol Med. 2020 April 17

Hasan* SS, Jabs M*, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne H-J, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A: Endothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med. 2020 March 18

Gaitantzi H, Karch J, Germann L, Cai C, Rausch V, Birgin E, Rahbari N, Seitz T, Hellerbrand C, König C, Augustin HG, Mogler C, de la Torre C, Gretz N, Itzel T, Teufel A, Ebert MPA, Breitkopf-Heinlein K: BMP-9 Modulates the Hepatic Responses to LPS. Cells. 2020 March 4

Jäger MA, De La Torre C, Arnold C, Kohlhaas J, Kappert L, Hecker M, Feldner A, Korff T: Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res. 2020 Mar 1

Aslan K, Turco V, Blobner J, Sonner JK, Liuzzi AR, Núñez NG, De Feo D, Kickingereder P, Fischer M, Green E, Sadik A, Friedrich M, Sanghvi K, Kilian M, Cichon F, Wolf L, Jähne K, von Landenberg A, Bunse L, Sahm F, Schrimpf D, Meyer J, Alexander A, Brugnara G, Röth R, Pfleiderer K, Niesler B, von Deimling A, Opitz C, Breckwoldt MO, Heiland S, Bendszus M, Wick W, Becher B, Platten M: Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas. Nat Commun. 2020 Feb 18

Singhal M, Augustin HG: Beyond Angiogenesis: Exploiting Angiocrine Factors to Restrict Tumor Progression and Metastasis. Cancer Res. 2020 Feb 15

Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. Proc Natl Acad Sci U S A. 2020 Feb 7

Zhang XJ, Olsavszky V, Yin Y, Wang B, Engleitner T, Öllinger R, Schledzewski K, Koch PS, Rad R, Schmid RM, Friess H, Goerdt S, Hüser N, Géraud C, von Figura G, Hartmann D: Angiocrine Hepatocyte Growth Factor Signaling Controls Physiological Organ and Body Size and Dynamic Hepatocyte Proliferation to Prevent Liver Damage during Regeneration. Am J Pathol. 2020 Feb

Bibli SI, Hu J, Leisegang MS, Wittig J, Zukunft S, Kapasakalidi A, Fisslthaler B, Tsilimigras D, Zografos G, Filis K, Brandes RP, Papapetropoulos A, Sigala F, Fleming I: Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation. Redox Biol. 2020 Jan;28

Wagner JUG, Pham MD, Nicin L, Hammer M, Bottermann K, Yuan T, Sharma R, John D, Muhly-Reinholz M, Tombor L, Hardt M, Madl J, Dimmeler S, Krishnan J: Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics. J Mol Cell Cardiol. 2020 Jan

2019

Luck R*, Urban S*, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, Ruiz de Almodóvar C: VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. Elife, 2019 Dec 23

Klose R, Prinz A, Tetzlaff F, Weis EM, Moll I, Rodriguez-Vita J, Oka C, Korff T, Fischer A: Loss of the serine protease HTRA1 impairs smooth muscle cells maturation. Scientific Reports. Dec 3, 2019

Tisch N, Freire-Valls A, Yerbes R, Paredes I, La Porta S, Wang X, Martín-Pérez R, Castro L, Wong WW, Coultas L, Strilic B, Gröne HJ, Hielscher T, Mogler C, Adams RH, Heiduschka P, Claesson-Welsh L, Mazzone M, López-Rivas A, Schmidt T, Augustin HG, Ruiz de Almodovar C: Caspase-8 modulates physiological and pathological angiogenesis during retina development. J Clin Invest. 2019 Dec 2

Park H, Yamamoto H, Mohn L, Ambühl L, Kanai L, Schmidt I, Kim KP, Fraccaroli A, Feil S, Junge HJ, Montanez E, Berger W* & Adams R*: Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat Commun 2019, November 20

Marín-Juez R, El-Sammak H, Helker CSM, Kamezaki A, Mullapuli ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR: Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Dev Cell 2019, November 18

Vidal R, Wagner JUG, Braeuning C, Fischer C, Patrick R, Tombor L, Muhly-Reinholz M, John D, Kliem M, Conrad T, Guimarães-Camboa N, Harvey R, Dimmeler S, Sauer S: Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart. JCI Insight. 2019 Nov 14

Collins MM, Ahlberg G, Hansen CV, Guenther S, Marín-Juez R, Sokol AM, El-Sammak H, Piesker J, Hellsten Y, Olesen MS, Stainier DYR: Lundegaard PR: Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model. Proc Natl Acad Sci U S A 2019, November 8.

Gancz D, Raftrey BC, Perlmoter G, Marín-Juez R, Semo J, Matsuoka RL, Karra R, Raviv H, Moshe N, Addadi Y, Golani O, Poss KD, Red-Horse K, Stainier DY, Yaniv K: Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. Elife 2019, November 8.

Freire Valls A*, Knipper K*, Giannakouri E, Sarachaga V, Hinterkopf S, Wuehrl M, Shen Y, Radhakrishnan P, Klose J, Ulrich A, Schneider M, Augustin HG, Ruiz de Almodovar C, Schmidt T: VEGFR1+ Metastasis-Associated Macrophages Contribute to Metastatic Angiogenesis and Influence Colorectal Cancer Patient Outcome. Clin Cancer Res. 2019 Sep 15

Li Q, Liu B, Breitkopf-Heinlein K, Weng H, Jiang Q, Dong P, Dooley S, Xu K, Ding H: Adenovirus‑mediated Overexpression of Bone Morphogenetic protein‑9 Promotes Methionine Choline deficiency‑induced non‑alcoholic Steatohepatitis in non‑obese Mice. Epub 2019 Jul 19

Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G: Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res. 2019 Jun

Schreiber C, Saraswati S, Harkins S, Gruber A, Cremers N, Thiele W, Rothley M, Plaumann D, Korn C, Armant O, Augustin HG, Sleeman JP: Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling. PLoS Genet. 2019 Jun 27

Lai SL, Marín-Juez R, Stainier DYR: Immune responses in cardiac repair and regeneration: a comparative point of view.

Cell Mol Life Sci. 2019 Apr

Karakatsani A, Shah B, Ruiz de Almodovar C: Blood vessels as regulators of neural stem cell properties. Front Mol Neurosci 2019, April 12.

Contact

Spokesperson

Prof. Dr. Hellmut G. Augustin

European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg

Vice Spokesperson

Prof. Dr. Sergij Goerdt

University Hospital for Dermatology,

Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim, Heidelberg University

CRC1366

Vas­cular Control of Organ Function

Publications

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2020

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2019

Vascular Control of Organ Function