The extended role of blood vessels
Blood vessels form a systemically disseminated organ that distributes oxygen and nutrients and removes metabolic waste products. A dense network of microvessels facilitates the trafficking of immune cells throughout the body. Yet, blood vessels do not just support rheological functions. They form one of the body’s largest surfaces serving as critical interface between the circulation and the different organ environments.
Work pursued in the last couple of years has identified critical gatekeeper functions of tissue homeostasis and adaptation to pathologic challenge. It is now increasingly recognized that vascular control of the tissue microenvironment is indispensable in development, homeostasis, inflammation, and metabolism as well as cancer and metastasis. This multitude of vascular functions is mediated by organ-specifically differentiated endothelial and mural cells, whose cellular and molecular heterogeneity has long been recognized.
Yet, distinct organotypic functional attributes as well as the molecular mechanisms controlling endothelial and mural cell differentiation and vascular bed-specific functions have only recently been uncovered. The Collaborative Research Center (CRC) 1366 “Vascular Control of Organ Function” aims at systematically studying gatekeeper functions of organotypically differentiated endothelial and mural cells during development and regeneration.
News and Upcoming Events
CRC1366/ECAS InSight
for complete schedule 2021 press here
Hadil El-Sammak
Vegfc signaling promotes coronary revascularization
during cardiac regeneration in zebrafish
Stainier / Marín-Juez Group
and
Yohanes Wibowo
The cyclic AMP effector Epac1 is a main endothelial
signaling hub
Wieland Group
and
Dr. Felix Trogisch
Endothelial Sox9 Is A Master Regulator of Cardiac
Fibrosis and Maladaptive Remodeling
Heineke Group
Wednesday, May 5, 2021
ONLINE via Cisco Webex Meetings
CRC1366/ECAS Seminars in Angioscience
Prof. Anne Eichmann
Vascular development: a cycle of sprouting,
remodeling and maturation
Yale Cardiovascular Research Center, USA
Thursday, May 27, 2021
ONLINE via Cisco Webex Meetings
Contact
Spokesperson
Prof. Dr. Hellmut G. Augustin
European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg
Vice Spokesperson
Prof. Dr. Sergij Goerdt
University Hospital for Dermatology,
Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim
Heidelberg University
Steering Committee
Prof. Dr. Ralf Adams
Max Planck Institute for Molecular Biomedicine, Münster
Department of Tissue Morphogenesis
Prof. Dr. Stefanie Dimmeler
Institute of Cardiovascular Regeneration
Goethe University, Frankfurt
Prof. Dr. Jörg Heineke
Dept. of Cardiovascular Research, European Center for Angioscience (ECAS),
Medical Faculty Mannheim, Heidelberg University
Prof. Dr. Carmen Ruiz de Almodóvar
European Center for Angioscience (ECAS)
Faculty of Medicine Mannheim, Heidelberg University
EVBO Seminars Series 2021
Short talk
Friedemann Kiefer, University of Muenster, MPI Muenster, Germany
‘Organotypic specialization of mesenteric lymphatic vessels’
Young Investigator Spotlight (YIS)
Roxana Ola, Heidelberg University, Germany
‘Klf4 plays a key determinant role in AVM pathology’
Plenary lecture
Oliver Söhnlein, University of Munich, LMU, Germany
‘Neutrophils in chronic inflammation: from physiology to
therapeutic intervention'
Wednesday, April 28, 2021, 15:00-16:00 European Summer Time (GMT+02:00)
Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"
Institute of Vascular Signaling, Center for Molecular Medicine, Goethe University Frankfurt, April 2021
Ralf Adams receives „Feldberg Prize“ 2021
Press release Max Planck Institute for Molecular Biomedicine, Münster, February 01, 2021
Blood vessels control organ function and disease processes
Press release Medical Faculty Mannheim University Heidelberg, December 04,2020
Lymphatics prevent spreading of cancer cells
Press release German Cancer Research Center (DKFZ), October 26, 2020
Endothelial cell-specific factor protects metastatic tumor cells
Press release German Cancer Research Center (DKFZ), May 26, 2020
HIF-1α decelerates natural Killer cells
Press release Medical Faculty Mannheim University Heidelberg May 22, 2020
Prevent metastasis - an antibody with potential
Press release German Cancer Research Center (DKFZ), April 24, 2020
The role of blood vessels in insulin resistance
Press release German Cancer Research Center (DKFZ), March 27, 2020
Carmen Ruiz de Almodóvar receives ERC Consolidator Grant
Press release Medical Faculty Mannheim University Heidelberg Dec. 10, 2019
Andreas Fischer receives Gábor Szász Award
Press release German Cancer Research Center (DKFZ), Oct. 7, 2019
Überlebensstrategien im Klub K: Ein bisschen Maß muss sein
Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019
Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten
Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)
Bericht im Mannheimer Morgen vom 1. März 2019
Pressemitteilung zum Kickoff Meeting
Michael Platten receives the German Cancer Award 2019
Bericht im Mannheimer Morgen vom 2. März 2019
Pressemitteilung vom 23.11.2018
Grünes Licht für neuen gefäßbiologischen Sonderforschungsbereich
Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.
