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Upcoming Seminars

CRC1366 / ECAS InSight

for complete schedule 2021 press here

Hadil El-Sammak

Stainier / Marín-Juez Group

and

Yohanes Wibowo

Wieland Group

and

Dr. Felix Trogisch

Heineke Group

Wednesday, May 5, 2021

more

CRC1366 / ECAS Seminars in Angioscience

Prof. Anne Eichmann

Yale Cardiovascular Research Center, USA

Thursday, May 27, 2021

more

EVBO Seminar Series 2021

Tuesday, April 28, 2021

registration and more

Events

2nd Joint Summer School and Consortium Meeting (internal)

April 21-23, 2021, Virtual

1st CRC1366 International Meeting: 

Vascular Control of Organ Function

June 28-30, 2021, DKFZ, Heidelberg

more

Publications

Tisch N & Ruiz de Almodóvar C

Contribution of cell death signaling to blood vessel formation

Cell Mol Life Sci​. 2021 Mar 30

Weber P, Baltus D, Jatho A et al.

RhoGEF17 – An essential regulator of endothelial cell death and growth.

Cells. 2021 Mar 27

Tombor LS, John D, Glaser SF et al.

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction.

Nat  Commun. 2021 Jan 29

Paredes I, Vieira JR, Shah B et al.

Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk.

Nat Neurosci. 2021 Jan 28

more

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The extended role of blood vessels

Blood vessels form a systemically disseminated organ that distributes oxygen and nutrients and re­moves metabolic waste products. A dense network of microvessels facilitates the trafficking of immune cells throughout the body. Yet, blood vessels do not just support rheological functions. They form one of the body’s largest surfaces serving as critical interface between the circulation and the different organ environments.

 

Work pursued in the last couple of years has identified critical gatekeeper functions of tissue homeostasis and adaptation to pathologic challenge. It is now increasingly recognized that vascular control of the tissue microenvironment is indispensable in development, homeostasis, inflammation, and metabolism as well as cancer and metastasis. This multitude of vascular functions is mediated by organ-specifically differentiated endothelial and mural cells, whose cellular and molecular heterogeneity has long been recognized.

 

Yet, distinct organotypic functional attributes as well as the molecular mechanisms controlling endothelial and mural cell differentiation and vascular bed-specific functions have only recently been uncovered. The Collaborative Research Center (CRC) 1366 “Vas­cular Control of Organ Function” aims at systematically studying gatekeeper functions of organotypically differentiated endothelial and mural cells during develop­ment and regeneration.

News and Upcoming Events

CRC1366/ECAS InSight

for complete schedule 2021 press here

Hadil El-Sammak

Vegfc signaling promotes coronary revascularization

during cardiac regeneration in zebrafish

Stainier / Marín-Juez Group

and

Yohanes Wibowo

The cyclic AMP effector Epac1 is a main endothelial

signaling hub

Wieland Group

and

Dr. Felix Trogisch

Endothelial Sox9 Is A Master Regulator of Cardiac

Fibrosis and Maladaptive Remodeling

Heineke Group

Wednesday, May 5, 2021

ONLINE via Cisco Webex Meetings

CRC1366/ECAS Seminars in Angioscience

Prof. Anne Eichmann

Vascular development: a cycle of sprouting,

remodeling and maturation

Yale Cardiovascular Research Center, USA

Thursday, May 27, 2021

ONLINE via Cisco Webex Meetings

Contact

 

 

 

 

 

 

 

 

 

 

Spokesperson

Prof. Dr. Hellmut G. Augustin

European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg

 

 

 

 

 

 

 

 

 

Vice Spokesperson

Prof. Dr. Sergij Goerdt

University Hospital for Dermatology,

Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim

Heidelberg University

Steering Committee 

Prof. Dr. Ralf Adams

Max Planck Institute for Molecular Biomedicine, Münster
Department of Tissue Morphogenesis

Prof. Dr. Stefanie Dimmeler

Institute of Cardiovascular Regeneration

Goethe University, Frankfurt

Prof. Dr. Jörg Heineke

Dept. of Cardiovascular Research, European Center for Angioscience (ECAS),

Medical Faculty Mannheim, Heidelberg University

Prof. Dr. Carmen Ruiz de Almodóvar

European Center for Angioscience (ECAS)
Faculty of Medicine Mannheim, Heidelberg University

EVBO Seminars Series 2021

Short talk

Friedemann Kiefer, University of Muenster, MPI Muenster, Germany

‘Organotypic specialization of mesenteric lymphatic vessels’

Young Investigator Spotlight (YIS)

Roxana Ola, Heidelberg University, Germany

‘Klf4 plays a key determinant role in AVM pathology’

Plenary lecture

Oliver Söhnlein, University of Munich, LMU, Germany

‘Neutrophils in chronic inflammation: from physiology to

therapeutic intervention'

 

Wednesday, April 28, 2021, 15:00-16:00 European Summer Time (GMT+02:00)

Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"

Institute of Vascular Signaling, Center for Molecular Medicine, Goethe University Frankfurt, April 2021

Ralf Adams receives „Feldberg Prize“ 2021

 Press release Max Planck Institute for Molecular Biomedicine, Münster, February 01, 2021

Blood vessels control organ function and disease processes

Press release Medical Faculty Mannheim University Heidelberg, December 04,2020

Lymphatics prevent spreading of cancer cells

Press release German Cancer Research Center (DKFZ), October 26, 2020 

Endothelial cell-specific factor protects metastatic tumor cells

Press release German Cancer Research Center (DKFZ), May 26, 2020 

HIF-1α decelerates natural Killer cells

Press release Medical Faculty Mannheim University Heidelberg May 22, 2020

Prevent metastasis - an antibody with potential

Press release German Cancer Research Center (DKFZ), April 24, 2020 

The role of blood vessels in insulin resistance

Press release German Cancer Research Center (DKFZ), March 27, 2020 

Carmen Ruiz de Almodóvar receives ERC Consolidator Grant

 Press release Medical Faculty Mannheim University Heidelberg Dec. 10, 2019

Andreas Fischer receives Gábor Szász Award

Press release German Cancer Research Center (DKFZ), Oct. 7, 2019

 

Überlebensstrategien im Klub K: Ein bisschen Maß muss sein

Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019

for more

 

Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten

Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)

 

Bericht im Mannheimer Morgen vom 1. März 2019

Pressemitteilung zum Kickoff Meeting

 

Michael Platten receives the German Cancer Award 2019

Bericht im Mannheimer Morgen vom 2. März 2019

 

Pressemitteilung vom 23.11.2018

Grünes Licht für neuen gefäßbiologischen Sonderforschungsbereich

Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University

Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450