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Upcoming Seminars

CRC1366 / ECAS InSight

for complete schedule 2021 press here

Dr. Katja Breitkopf-Heinlein

Breitkopf-Heinlein Group

and

Lukas Tombor

Dimmeler Group

Wednesday, July 7, 2021

more

CRC1366 / ECAS Seminars in Angioscience

TBA

TBA

Thursday, July 15, 2021

more

EVBO Seminar Series 2021

Thursday, July 1, 2021

registration and more

Events

1st CRC1366 International Meeting: 

Vascular Control of Organ Function

June 28-30, 2021, online

Registration closes on June 6, 2021

more

Publications

Alsina-Sanchis E, Mülfarth R, Fischer A.

Control of Tumor Progression by Angiocrine Factors. 

Cancers. 2021 May 26.

Inverso D, Shi J, Lee KH et al.

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver.

Developmental Cell. 2021 May 25.

Zhang XW, Huck K, Jähne K et al.

Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma.

Oncoimmunology. 2021 May 14.

Jiang X, Hu J, Wu Z, Cafarello ST et al.

Protein Phosphatase 2A mediates YAP activation in endothelial cells upon VEGF stimulation and matrix stiffness.

Front. Cell Dev. Biol. 2021 May 13.

more

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The extended role of blood vessels

Blood vessels form a systemically disseminated organ that distributes oxygen and nutrients and re­moves metabolic waste products. A dense network of microvessels facilitates the trafficking of immune cells throughout the body. Yet, blood vessels do not just support rheological functions. They form one of the body’s largest surfaces serving as critical interface between the circulation and the different organ environments.

 

Work pursued in the last couple of years has identified critical gatekeeper functions of tissue homeostasis and adaptation to pathologic challenge. It is now increasingly recognized that vascular control of the tissue microenvironment is indispensable in development, homeostasis, inflammation, and metabolism as well as cancer and metastasis. This multitude of vascular functions is mediated by organ-specifically differentiated endothelial and mural cells, whose cellular and molecular heterogeneity has long been recognized.

 

Yet, distinct organotypic functional attributes as well as the molecular mechanisms controlling endothelial and mural cell differentiation and vascular bed-specific functions have only recently been uncovered. The Collaborative Research Center (CRC) 1366 “Vas­cular Control of Organ Function” aims at systematically studying gatekeeper functions of organotypically differentiated endothelial and mural cells during develop­ment and regeneration.

News and Upcoming Events

CRC1366/ECAS InSight

for complete schedule 2021 press here

Dr. Katja Breitkopf-Heinlein

Differential BMP-9/ALK1 signalling outcome in human

endothelial and epithelial cell types of gut and liver

Breitkopf-Heinlein Group

and

Lukas Tombor

Dimmeler Group

Endothelial plasticity after myocardial infarct

Goerdt/Koch Group

Wednesday, July 7, 2021

ONLINE via Cisco Webex Meetings

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CRC1366/ECAS Seminars in Angioscience

TBA

TBA

TBA

Thursday, July 15, 2021

ONLINE via Cisco Webex Meetings

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Contact

 

 

 

 

 

 

 

 

 

 

Spokesperson

Prof. Dr. Hellmut G. Augustin

European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg

 

 

 

 

 

 

 

 

 

Vice Spokesperson

Prof. Dr. Sergij Goerdt

University Hospital for Dermatology,

Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim

Heidelberg University

Steering Committee 

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Prof. Dr. Ralf Adams

Max Planck Institute for Molecular Biomedicine, Münster
Department of Tissue Morphogenesis

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Prof. Dr. Stefanie Dimmeler

Institute of Cardiovascular Regeneration

Goethe University, Frankfurt

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Prof. Dr. Jörg Heineke

Dept. of Cardiovascular Research, European Center for Angioscience (ECAS),

Medical Faculty Mannheim, Heidelberg University

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Prof. Dr. Carmen Ruiz de Almodóvar

European Center for Angioscience (ECAS)
Faculty of Medicine Mannheim, Heidelberg University

EVBO Seminars Series 2021

Short talk

Anjali Kusumbe, University of Oxford, Kennedy Institute

of Rheumatology, Nuffield Department of Orthopaedics,

Rheumatology, and Musculoskeletal Sciences, UK

‘Vascular attrition and organ-specific vascular changes

mark the onset of tissue aging

Young Investigator Spotlight (YIS)

Oliver Stone, University of Oxford, UK

‘Developmental origins of lymphatic endothelial cells

Plenary lecture

Sirpa Jalkanen, University of Turku, Finland

‘New tools to target lymphatics for preventing cancer spread’

Thursday, July 1, 2021, 15:00-16:00 European Summer Time (GMT+02:00)

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Mahak Singhal receives the Helmholtz Doctoral Prize 2020

Press release Medical Faculty Mannheim University Heidelberg, May 2021

Didier Stainier receives ERC Advanced Grant

Max Planck Institute for Heart and Lung Research, Bad Nauheim, April 2021

Cyrill Géraud receives "Paul Langerhans-Pize" 2021

Press release Medical Faculty Mannheim University Heidelberg, April 2021

Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"

Institute of Vascular Signaling, Center for Molecular Medicine, Goethe University Frankfurt, April 2021

Ralf Adams receives „Feldberg Prize“ 2021

 Press release Max Planck Institute for Molecular Biomedicine, Münster, February 01, 2021

Blood vessels control organ function and disease processes

Press release Medical Faculty Mannheim University Heidelberg, December 04,2020

Lymphatics prevent spreading of cancer cells

Press release German Cancer Research Center (DKFZ), October 26, 2020 

Endothelial cell-specific factor protects metastatic tumor cells

Press release German Cancer Research Center (DKFZ), May 26, 2020 

HIF-1α decelerates natural Killer cells

Press release Medical Faculty Mannheim University Heidelberg May 22, 2020

Prevent metastasis - an antibody with potential

Press release German Cancer Research Center (DKFZ), April 24, 2020 

The role of blood vessels in insulin resistance

Press release German Cancer Research Center (DKFZ), March 27, 2020 

Carmen Ruiz de Almodóvar receives ERC Consolidator Grant

 Press release Medical Faculty Mannheim University Heidelberg Dec. 10, 2019

Andreas Fischer receives Gábor Szász Award

Press release German Cancer Research Center (DKFZ), Oct. 7, 2019

 

Überlebensstrategien im Klub K: Ein bisschen Maß muss sein

Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019

for more

 

Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten

Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)

 

Bericht im Mannheimer Morgen vom 1. März 2019

Pressemitteilung zum Kickoff Meeting

 

Michael Platten receives the German Cancer Award 2019

Bericht im Mannheimer Morgen vom 2. März 2019

 

Pressemitteilung vom 23.11.2018

Grünes Licht für neuen gefäßbiologischen Sonderforschungsbereich

Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.

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