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Upcoming Seminars

CRC1366 / ECAS InSight

TBA

and

TBA

Wednesday, February 14, 2024

CRC1366 / ECAS Seminars in Angioscience

Prof. Eckhard Lammert 

Heinrich Heine University Düsseldorf, Germany

Thursday, February 15, 2024

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Events

CRC1366 Winter School & Consortium Meeting (internal)

January 10-12, 2024,

Hotel Löwengarten, Speyer| GER

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EMBO Workshop

The new cardiobiology

February 20-23, 2024,

EMBL, Heidelberg| GER

more

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International Meeting on Vascular Control of Organ Function

May 13-15, 2024,

Alte Brauerei, Mannheim | GER

more

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Publications

Wardman R, Keles M, Pachkiv I et al.

RNA-Binding Proteins Regulate Post-Transcriptional Responses to TGF-β to Coordinate Function and Mesenchymal Activation of Murine Endothelial Cells.

Arterioscler Thromb Vasc Biol. 2023 Oct 1

Taylor J, Uhl L, Moll I et al.

Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia.

Nat Cancer. 2023 Sep 25

Wagner JUG, Tombor LS, Malacarne PF et al.

Aging impairs the neurovascular interface in the heart.

Science. 2023 Aug 25.

more

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The extended role of blood vessels

Blood vessels form a systemically disseminated organ that distributes oxygen and nutrients and re­moves metabolic waste products. A dense network of microvessels facilitates the trafficking of immune cells throughout the body. Yet, blood vessels do not just support rheological functions. They form one of the body’s largest surfaces serving as critical interface between the circulation and the different organ environments.

 

Work pursued in the last couple of years has identified critical gatekeeper functions of tissue homeostasis and adaptation to pathologic challenge. It is now increasingly recognized that vascular control of the tissue microenvironment is indispensable in development, homeostasis, inflammation, and metabolism as well as cancer and metastasis. This multitude of vascular functions is mediated by organ-specifically differentiated endothelial and mural cells, whose cellular and molecular heterogeneity has long been recognized.

 

Yet, distinct organotypic functional attributes as well as the molecular mechanisms controlling endothelial and mural cell differentiation and vascular bed-specific functions have only recently been uncovered. The Collaborative Research Center (CRC) 1366 “Vas­cular Control of Organ Function” aims at systematically studying gatekeeper functions of organotypically differentiated endothelial and mural cells during develop­ment and regeneration.

Überlebensstrategien - Blutgefäße für ein langes Leben

Überlebensstrategien” is a joint project of the Life Science Collaborative Research Centers of Heidelberg University and Rhein-Neckar Fernsehen (RNF). In an informal setting at the Karlstorbahnhof in Heidelberg and with musical accompaniment by members of the Collegium Musicum, the Collaborative Research Centres will present their questions and long-term goals.

On October 14, 2021, Prof. Hellmut Augustin, Prof. Maliha Sadick and Prof. Andreas Fischer gave a public presentation on “Gesunde Blutgefäße für ein langes Leben” (Healthy blood vessels for a long life). The presentation is only available in German.

News

The CRC1366 “Vascular Control of Organ Function” at Heidelberg University will continue its successful work for another four years

Press release Medical Faculty Mannheim, Heidelberg University, November 2022

Press release Heidelberg University, November 2022

 

Mahak Singhal receives the Helmholtz Doctoral Prize 2020

Press release Medical Faculty Mannheim University Heidelberg, May 2021

Didier Stainier receives ERC Advanced Grant

Max Planck Institute for Heart and Lung Research, Bad Nauheim, April 2021

Cyrill Géraud receives "Paul Langerhans-Pize" 2021

Press release Medical Faculty Mannheim University Heidelberg, April 2021

Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"

Institute of Vascular Signaling, Center for Molecular Medicine, Goethe University Frankfurt, April 2021

Ralf Adams receives „Feldberg Prize“ 2021

Press release Max Planck Institute for Molecular Biomedicine, Münster, February 01, 2021

Blood vessels control organ function and disease processes

Press release Medical Faculty Mannheim University Heidelberg, December 04,2020

Lymphatics prevent spreading of cancer cells

Press release German Cancer Research Center (DKFZ), October 26, 2020 

Endothelial cell-specific factor protects metastatic tumor cells

Press release German Cancer Research Center (DKFZ), May 26, 2020 

HIF-1α decelerates natural Killer cells

Press release Medical Faculty Mannheim University Heidelberg May 22, 2020

Prevent metastasis - an antibody with potential

Press release German Cancer Research Center (DKFZ), April 24, 2020 

The role of blood vessels in insulin resistance

Press release German Cancer Research Center (DKFZ), March 27, 2020 

Carmen Ruiz de Almodóvar receives ERC Consolidator Grant

Press release Medical Faculty Mannheim University Heidelberg Dec. 10, 2019

Andreas Fischer receives Gábor Szász Award

Press release German Cancer Research Center (DKFZ), Oct. 7, 2019

 

Überlebensstrategien im Klub K: Ein bisschen Maß muss sein

Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019

for more

 

Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten

Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)

 

Bericht im Mannheimer Morgen vom 1. März 2019

Pressemitteilung zum Kickoff Meeting

 

Michael Platten receives the German Cancer Award 2019

Bericht im Mannheimer Morgen vom 2. März 2019

 

Pressemitteilung vom 23.11.2018

Grünes Licht für neuen gefäßbiologischen Sonderforschungsbereich

Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.

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