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Upcoming Seminars

CRC1366 / ECAS InSight

for complete schedule 2021 press here

Dr. Carolin Mogler

Schönberg/Mogler Group

and

Merve Keles

Heineke Group

and

Dr. Nirmeen Elmadany

Platten Group

Wednesday, December 1, 2021

more

CRC1366 / ECAS Seminars in Angioscience

Prof. Daniela Duarte Campos

ZMBH, University of Heidelberg,

Thursday, November 11, 2021

more

EVBO Seminar Series 2021

wednesday, December 8, 2021,

15:00-16:00 (GMT+01:00)

registration and more

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Events

 

 

 

 

 

 

 

 

3rd Joint Winter School and Consortium Meeting 2022 (intern)

January 19-21, 2022, Asselheim

Register here

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Publications

Singhal M*, Gengenbacher N*, Abdul Pari AA* et al.

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis.

Sci. Transl. Med. 2021 September 1.

Stojanovic A, Cerwenka A

An intimate encounter: DC3s empower anti-tumor CTLs.

Cancer Cell. 2021 August 19.

Luck R, Karakatsani A, Shah B et al.

The angiopoietin-Tie2 pathway re-gulates Purkinje cell dendritic morphogenesis in a cell-autonom-ous manner. 

Cell reports. 2021 August 17.

Kappert L, Ruzicka P, Kutikhin A et al.

Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells.

FASEB J. 2021 August 12.

more

The extended role of blood vessels

Blood vessels form a systemically disseminated organ that distributes oxygen and nutrients and re­moves metabolic waste products. A dense network of microvessels facilitates the trafficking of immune cells throughout the body. Yet, blood vessels do not just support rheological functions. They form one of the body’s largest surfaces serving as critical interface between the circulation and the different organ environments.

 

Work pursued in the last couple of years has identified critical gatekeeper functions of tissue homeostasis and adaptation to pathologic challenge. It is now increasingly recognized that vascular control of the tissue microenvironment is indispensable in development, homeostasis, inflammation, and metabolism as well as cancer and metastasis. This multitude of vascular functions is mediated by organ-specifically differentiated endothelial and mural cells, whose cellular and molecular heterogeneity has long been recognized.

 

Yet, distinct organotypic functional attributes as well as the molecular mechanisms controlling endothelial and mural cell differentiation and vascular bed-specific functions have only recently been uncovered. The Collaborative Research Center (CRC) 1366 “Vas­cular Control of Organ Function” aims at systematically studying gatekeeper functions of organotypically differentiated endothelial and mural cells during develop­ment and regeneration.

News and Upcoming Events

CRC1366/ECAS InSight

for complete schedule 2021 press here

Dr. Carolin Mogler

Histological spectrum of liver lesions in rodent models for

liver tumorigenesis

Schönberg/Mogler Group

and

Merve Keles

Deletion of long non-coding RNAs GADLOR1 and GADLOR2

preserves cardiac function during pressure overload

Heineke Group

and

Dr. Nirmeen Elmadany

Investigating molecular targets in glioma-derived

endothelial cells for a better response to immunotherapy

Platten Group

Wednesday, December 1, 2021, ONLINE via Cisco Webex Meetings

CRC1366/ECAS Seminars in Angioscience

Prof. Daniela Duarte Campos

Bioprinting for tissue and organ engineering

ZMBH, University of Heidelberg, Germany
Thursday, November 11, 2021

ONLINE via Cisco Webex Meetings

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Contact

 

 

 

 

 

 

 

 

 

 

Spokesperson

Prof. Dr. Hellmut G. Augustin

European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg

 

 

 

 

 

 

 

 

 

Vice Spokesperson

Prof. Dr. Sergij Goerdt

University Hospital for Dermatology,

Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim

Heidelberg University

Steering Committee 

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Prof. Dr. Ralf Adams

Max Planck Institute for Molecular Biomedicine, Münster
Department of Tissue Morphogenesis

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Prof. Dr. Stefanie Dimmeler

Institute of Cardiovascular Regeneration

Goethe University, Frankfurt

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Prof. Dr. Jörg Heineke

Dept. of Cardiovascular Research, European Center for Angioscience (ECAS),

Medical Faculty Mannheim, Heidelberg University

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Prof. Dr. Carmen Ruiz de Almodóvar

European Center for Angioscience (ECAS)
Faculty of Medicine Mannheim, Heidelberg University

EVBO Seminars Series 2021

Short talk

Heinz-Georg Belting, University Basel, Switzerland

In vivo analysis of junctional dynamics during angiogenic

sprouting and lumen formation

Young Investigator Spotlight (YIS)

Georgina Zarcada, Yale School of Medicine, UK

Endothelial cell heterogeneity during sprouting angiogenesis

Plenary lecture

Lars Mägdefessel, Technical University Munich, Germany

‘Non-coding RNAs in vascular cell therapy’

Monday, November 8, 2021, 15:00-16:00 European Wummer Time (GMT+01:00)

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Überlebensstrategien - Blutgefäße für ein langes Leben

Überlebensstrategien” is a joint project of the Life Science Collaborative Research Centers of Heidelberg University and Rhein-Neckar Fernsehen (RNF). In an informal setting at the Karlstorbahnhof in Heidelberg and with musical accompaniment by members of the Collegium Musicum, the Collaborative Research Centres will present their questions and long-term goals.

On October 14, 2021, Prof. Hellmut Augustin, Prof. Maliha Sadick and Prof. Andreas Fischer gave a public presentation on “Gesunde Blutgefäße für ein langes Leben” (Healthy blood vessels for a long life). The presentation is only available in German.

Mahak Singhal receives the Helmholtz Doctoral Prize 2020

Press release Medical Faculty Mannheim University Heidelberg, May 2021

Didier Stainier receives ERC Advanced Grant

Max Planck Institute for Heart and Lung Research, Bad Nauheim, April 2021

Cyrill Géraud receives "Paul Langerhans-Pize" 2021

Press release Medical Faculty Mannheim University Heidelberg, April 2021

Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"

Institute of Vascular Signaling, Center for Molecular Medicine, Goethe University Frankfurt, April 2021

Ralf Adams receives „Feldberg Prize“ 2021

 Press release Max Planck Institute for Molecular Biomedicine, Münster, February 01, 2021

Blood vessels control organ function and disease processes

Press release Medical Faculty Mannheim University Heidelberg, December 04,2020

Lymphatics prevent spreading of cancer cells

Press release German Cancer Research Center (DKFZ), October 26, 2020 

Endothelial cell-specific factor protects metastatic tumor cells

Press release German Cancer Research Center (DKFZ), May 26, 2020 

HIF-1α decelerates natural Killer cells

Press release Medical Faculty Mannheim University Heidelberg May 22, 2020

Prevent metastasis - an antibody with potential

Press release German Cancer Research Center (DKFZ), April 24, 2020 

The role of blood vessels in insulin resistance

Press release German Cancer Research Center (DKFZ), March 27, 2020 

Carmen Ruiz de Almodóvar receives ERC Consolidator Grant

 Press release Medical Faculty Mannheim University Heidelberg Dec. 10, 2019

Andreas Fischer receives Gábor Szász Award

Press release German Cancer Research Center (DKFZ), Oct. 7, 2019

 

Überlebensstrategien im Klub K: Ein bisschen Maß muss sein

Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019

for more

 

Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten

Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)

 

Bericht im Mannheimer Morgen vom 1. März 2019

Pressemitteilung zum Kickoff Meeting

 

Michael Platten receives the German Cancer Award 2019

Bericht im Mannheimer Morgen vom 2. März 2019

 

Pressemitteilung vom 23.11.2018

Grünes Licht für neuen gefäßbiologischen Sonderforschungsbereich

Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.

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