CRC1366
Vascular Control of Organ Function
Upcoming Seminars
CRC1366 / ECAS InSight
for complete schedule 2021 press here
Dr. Carolin Mogler
Schönberg/Mogler Group
and
Merve Keles
Heineke Group
and
Dr. Nirmeen Elmadany
Platten Group
Wednesday, December 1, 2021
CRC1366 / ECAS Seminars in Angioscience
Prof. Michael Potente
Berlin Institute of Health & Max Delbrück Center for Molecular Medicine,
Thursday, December 9, 2021
EVBO Seminar Series 2021
Wednesday, December 8, 2021,
15:00-16:00 (GMT+01:00)
Publications
Heil J, Olsavszky V, Busch K et al.
Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.
Nat Commun. 2021 November 29.
Cai C, Itzel T, Gaitantzi H et al.
Identification of liver-derived bone morphogenetic protein (BMP)-9 as a potential new candidate for treatment of colorectal cancer.
J Cell Mol Med. 2021 Nov 28.
Singhal M*, Gengenbacher N*, Abdul Pari AA* et al.
Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis.
Sci. Transl. Med. 2021 September 1.
An intimate encounter: DC3s empower anti-tumor CTLs.
Cancer Cell. 2021 August 19.
The extended role of blood vessels
Blood vessels form a systemically disseminated organ that distributes oxygen and nutrients and removes metabolic waste products. A dense network of microvessels facilitates the trafficking of immune cells throughout the body. Yet, blood vessels do not just support rheological functions. They form one of the body’s largest surfaces serving as critical interface between the circulation and the different organ environments.
Work pursued in the last couple of years has identified critical gatekeeper functions of tissue homeostasis and adaptation to pathologic challenge. It is now increasingly recognized that vascular control of the tissue microenvironment is indispensable in development, homeostasis, inflammation, and metabolism as well as cancer and metastasis. This multitude of vascular functions is mediated by organ-specifically differentiated endothelial and mural cells, whose cellular and molecular heterogeneity has long been recognized.
Yet, distinct organotypic functional attributes as well as the molecular mechanisms controlling endothelial and mural cell differentiation and vascular bed-specific functions have only recently been uncovered. The Collaborative Research Center (CRC) 1366 “Vascular Control of Organ Function” aims at systematically studying gatekeeper functions of organotypically differentiated endothelial and mural cells during development and regeneration.
News and Upcoming Events
CRC1366/ECAS InSight
for complete schedule 2021 press here
Dr. Carolin Mogler
Histological spectrum of liver lesions in rodent models for
liver tumorigenesis
Schönberg/Mogler Group
and
Merve Keles
Deletion of long non-coding RNAs GADLOR1 and GADLOR2
preserves cardiac function during pressure overload
Heineke Group
and
Dr. Nirmeen Elmadany
Investigating molecular targets in glioma-derived
endothelial cells for a better response to immunotherapy
Platten Group
Wednesday, December 1, 2021, ONLINE via Cisco Webex Meetings
CRC1366/ECAS Seminars in Angioscience
Prof. Michael Potente
Metabolic guidance of angiogenic blood vessel growth
Berlin Institute of Health & Max Delbrück Center for Molecular Medicine, Germany
Thursday, December 9, 2021
ONLINE via Cisco Webex Meetings
Contact
Spokesperson
Prof. Dr. Hellmut G. Augustin
European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg
Vice Spokesperson
Prof. Dr. Sergij Goerdt
University Hospital for Dermatology,
Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim
Heidelberg University
Steering Committee
Prof. Dr. Ralf Adams
Max Planck Institute for Molecular Biomedicine, Münster
Department of Tissue Morphogenesis
Prof. Dr. Stefanie Dimmeler
Institute of Cardiovascular Regeneration
Goethe University, Frankfurt
Prof. Dr. Jörg Heineke
Dept. of Cardiovascular Research, European Center for Angioscience (ECAS),
Medical Faculty Mannheim, Heidelberg University
Prof. Dr. Carmen Ruiz de Almodóvar
European Center for Angioscience (ECAS)
Faculty of Medicine Mannheim, Heidelberg University
EVBO Seminars Series 2021
Short talk
Heinz-Georg Belting, University Basel, Switzerland
In vivo analysis of junctional dynamics during angiogenic
sprouting and lumen formation
Young Investigator Spotlight (YIS)
Georgina Zarcada, Yale School of Medicine, UK
Endothelial cell heterogeneity during sprouting angiogenesis
Plenary lecture
Lars Mägdefessel, Technical University Munich, Germany
‘Non-coding RNAs in vascular cell therapy’
Monday, November 8, 2021, 15:00-16:00 European Wummer Time (GMT+01:00)
Überlebensstrategien - Blutgefäße für ein langes Leben
“Überlebensstrategien” is a joint project of the Life Science Collaborative Research Centers of Heidelberg University and Rhein-Neckar Fernsehen (RNF). In an informal setting at the Karlstorbahnhof in Heidelberg and with musical accompaniment by members of the Collegium Musicum, the Collaborative Research Centres will present their questions and long-term goals.
On October 14, 2021, Prof. Hellmut Augustin, Prof. Maliha Sadick and Prof. Andreas Fischer gave a public presentation on “Gesunde Blutgefäße für ein langes Leben” (Healthy blood vessels for a long life). The presentation is only available in German.
Mahak Singhal receives the Helmholtz Doctoral Prize 2020
Press release Medical Faculty Mannheim University Heidelberg, May 2021
Didier Stainier receives ERC Advanced Grant
Max Planck Institute for Heart and Lung Research, Bad Nauheim, April 2021
Cyrill Géraud receives "Paul Langerhans-Pize" 2021
Press release Medical Faculty Mannheim University Heidelberg, April 2021
Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"
Institute of Vascular Signaling, Center for Molecular Medicine, Goethe University Frankfurt, April 2021
Ralf Adams receives „Feldberg Prize“ 2021
Press release Max Planck Institute for Molecular Biomedicine, Münster, February 01, 2021
Blood vessels control organ function and disease processes
Press release Medical Faculty Mannheim University Heidelberg, December 04,2020
Lymphatics prevent spreading of cancer cells
Press release German Cancer Research Center (DKFZ), October 26, 2020
Endothelial cell-specific factor protects metastatic tumor cells
Press release German Cancer Research Center (DKFZ), May 26, 2020
HIF-1α decelerates natural Killer cells
Press release Medical Faculty Mannheim University Heidelberg May 22, 2020
Prevent metastasis - an antibody with potential
Press release German Cancer Research Center (DKFZ), April 24, 2020
The role of blood vessels in insulin resistance
Press release German Cancer Research Center (DKFZ), March 27, 2020
Carmen Ruiz de Almodóvar receives ERC Consolidator Grant
Press release Medical Faculty Mannheim University Heidelberg Dec. 10, 2019
Andreas Fischer receives Gábor Szász Award
Press release German Cancer Research Center (DKFZ), Oct. 7, 2019
Überlebensstrategien im Klub K: Ein bisschen Maß muss sein
Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019
Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten
Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)
Bericht im Mannheimer Morgen vom 1. März 2019
Pressemitteilung zum Kickoff Meeting
Michael Platten receives the German Cancer Award 2019
Bericht im Mannheimer Morgen vom 2. März 2019
Pressemitteilung vom 23.11.2018
Grünes Licht für neuen gefäßbiologischen Sonderforschungsbereich
Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.
