CRC1366
Vascular Control of Organ Function
News and Events
Upcoming Events
Contact
Spokesperson
Prof. Dr. Hellmut G. Augustin
European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg
Vice Spokesperson
Prof. Dr. Sergij Goerdt
University Hospital for Dermatology,
Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim, Heidelberg University
CRC1366/ECAS InSight
for complete schedule 2021 press here
Dr. Katja Breitkopf-Heinlein
Differential BMP-9/ALK1 signalling outcome in human
endothelial and epithelial cell types of gut and liver
Breitkopf-Heinlein Group
and
Lukas Tombor
Endothelial plasticity after myocardial infarct
Dimmeler Group
Wednesday, July 7, 2021, ONLINE via Cisco Webex Meetings
CRC1366/ECAS Seminars in Angioscience
TBA
TBA
TBA
Thursday, July 15, 2021, ONLINE via Cisco Webex Meetings
2nd Joint Summer School and
Consortium Meeting 2021
April 21-23, 2021
News
Mahak Singhal receives the Helmholtz Doctoral Prize 2020
Mahak Singhal from the Augustin Group received the Helmholtz Doctoral Prize 2020
that is awarded by the Helmholtz Association to young researchers who have completed
their doctorate at a Helmholtz Center and obtained outstanding results.
Mahak Singhal received the award for his research on the interface between vascular
biology and tumor biology leading to a better understanding of the mechanisms of
metastasis formation in order to develop new diagnostic and therapeutic methods.
Cyrill Géraud receives “Paul-Langerhans-Preis 2021”
Cyrill Géraud receives “Paul-Langerhans-Preis 2021”, which is awarded by the “Arbeitsgemeinschaft Dermatologische Forschung“ (ADF e.V.) to „highly qualified dermatological scientists with continuous, first-class and innovative research activities”.
Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"
Prof. Dr. Sofia-Iris Bibli receives one of the prestigious Emmy Noether Grants from the German Research Foundation (DFG). Advanced age is the dominant unmodifiable risk factor for cardiovascular diseases and strategies to rejuvenate the senescent endothelium remain far away from the clinic. Metabolic adaptation seems to be the key for the preservation of endothelial homeostasis. To this end, Prof. Bibli and her team will investigate the role of rewired cysteine metabolism in vascular aging and
regeneration and will be funded to establish an Emmy Noether Group in the Institute for Vascular Signaling at the Goethe University.
In addition, she received the Oskar-Lapp-Prize for her Publication "Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function".
Ralf Adams receives „Feldberg Prize“ 2021
Ralf Adams, Director at the Max Planck Institute for Molecular Biomedicine in Münster, receives the Feldberg Prize 2021, which is awarded annually by the Feldberg Foundation for Anglo-German Scientific Exchange to one researcher in Germany and one in the United Kingdom. The purpose of the Foundation and the prize is the promotion of scientific contact between German and English scientists within the sphere of experimental medical research.
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
The research team of Stefanie Dimmeler showed that endothelial cells show transient mesenchymal phenotype after infarct. Single-cell RNA sequencing was used together with in vivo tracing methods to decipher cellular heterogeneity. Remarkably, endothelial cells show a transient mesenchymal phenotype within the first days upon myocardial infarction. However, at later stages, these cells do not acquire a long-term mesenchymal fate. Hence, this process termed as EndMA (Endothelial to Mesenchymal Activation) which might be required for facilitating tissue regeneration.
PRESS RELEASE. https://doi.org/10.1038/s41467-021-20905-1
Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk
The research team of Carmen Ruiz de Almodóvar provided new evidence that blood vessels can control and regulate organ function. They observed a crosstalk between the neural and the vascular compartment of the developing central nervous system inducing neural progenitor cells to specialize into oligodendrocyte progenitor cells.
PRESS RELEASE. https://doi.org/10.1038/s41593-020-00788-z
Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling
The research team of Sergij Goerdt, Philipp Reiners-Koch and Cyrill Géraud gained new insights into regulation of liver fibrosis and liver regeneration. They observed that blood vessel malfunction in the liver causes liver dysfunction confirming that blood vessels are able to control organ function as well as disease processes. Furthermore, they identified the GATA4/MYC/PDGFB/PDGFRβ axis as promising therapeutic approach.
PRESS RELEASE. https://doi.org/10.1016/j.jhep.2020.08.033
Signaling pathway for tumor spread via lymph vessels discovered
Hellmut Augustin and colleagues from the DKFZ have developed a new animal model to investigate the spread of tumor cells and ways to block the spread of the often fatal colonization. Using an antibody against Ang2 caused lymphatic vessels to die, thereby preventing metastasis and prolonging survival of tumor-bearing mice. With this finding they validated a proof-of-concept for the development of new treatment strategies to prevent the dangerous spreading of tumor cells.
doi.org/10.1158/2159-8290.CD-20-0122
Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma
Hellmut Augustin and colleagues have identified Ang2-producing tumor cells in a subset of melanoma patients with evident metastases formation. Further studies in mice revealed that tumor cells that produce angiopoietin-2 are protected against cell stress and therefore have an advantage in metastasis.
doi.org/10.1158/0008-5472.CAN-19-2660
Switching off Hif-1 in NK cells slows Tumor growth
Adelheid Cerwenka and colleagues have identified a key molecule that slows down the activity of natural killer cells in tumor defense. Solving this brake could be a promising strategy to improve NK cell-based immunotherapies against solid Tumors.
doi.org/10.1016/j.immuni.2020.05.001
A novel endothelial-specific Receptor Function-Blocking Antibody inhibits Metastasis
Hellmut Augustin and colleagues have succeeded in blocking a rarely studied endothelial-specific receptor with an antibody and thus preventing the formation of metastases in mice with breast or lung cancer. They could demonstrate a new principle how the relocation of cancer cells could be slowed down in the future.
doi.org/10.15252/emmm.201911164
Endothelial Notch Signaling Controls Insulin Transport in Muscle
Andreas Fischer and colleagues have found that in obese mice, a signaling pathway has been stimulated that prevents Insulin from crossing the endothelial cell layer, a prerequisite for its function, and thus promotes insulin resistance. This result helps to better understand metabolic syndrome and the development of Diabetes.
doi: 10.15252/emmm.201809271. Epub 2020 Mar 18.
Carmen Ruiz de Almodóvar receives ERC Consolidator Grant
for the project "The Oligo-Vascular Interface: Understanding its Properties and Functions"
The group has identified an 'oligo-vascular interface', whereby vessels send out signals to
directly control the generation of oligodendrocyte precursor cells. Her research will focus
on the identification of molecular interactions between blood vessels and oligodendrocytes
during development, homeostasis and in conditions of demyelinating diseases.
The CRC1366 has now 5 PIs from 25 currently holding funded ERC grants.
Press release Nachrichten Informationsdienst Wissenschaft (idw), Dec. 10, 2019
Andreas Fischer receives Gábor Szász Award
for his research on the importance of the endothelium - the cells that line the blood vessels
from the inside - in the spread of cancer. The researchers could show that cancer cells
reprogramm the endothelium thereby increasing the production of a contact molecule that
allows cancer cells to attach to the vessel wall and prepare for passage into the blood vessels.
The activated signaling pathway facilitates cancer cells' access to the bloodstream and metastasis
to other organs and the production of messengers that attract cancer-promoting immune cells
into the tumor.
Press release German Cancer Research Center (DKFZ), Oct. 7, 2019
Überlebensstrategien im Klub K: Ein bisschen Maß muss sei
Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019
Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten
Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)
Bericht im Mannheimer Morgen vom 1. März 2019
Pressemitteilung zum Kickoff Meeting
Michael Platten receives the German Cancer Award 2019
Pressemitteilung vom 23.11.2018
GRÜNES LICHT FÜR NEUEN GEFÄSSBIOLOGISCHEN SONDERFORSCHUNGSBEREICH
Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.
Switching off Hif-1 in NK cells slows Tumor growth
Prof. Cerwenka and colleagues from the German Cancer Research Center (DKFZ), have identified a key molecule that slows down the activity of natural killer cells in tumor defense. Solving this brake could be a promising strategy to improve NK cell-based immunotherapies against solid Tumors.
Source: Anspach / DKFZ
Past Events
Lymphatic endothelial regulation of tumor immunity
Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland
Friday, June 18, 2021, ONLINE via Cisco Webex Meetings
Endothelial de-CYS-tiny: Cysteinolysis and endothelial cell fates
and
Dr. Victor Olsavszky
Activating β-Catenin mutation in bone marrow sinusoidal endothelium leads to dyserythropoiesis
Wednesday, June 16, 2021, ONLINE via Cisco Webex Meetings
Prof. Elisabetta Dejana
Heterogeneity of endothelial cells in cerebral cavernous malformations
Department of Immunology, Genetics & Pathology, Uppsala University, Sweden
University of Milan, Italy
Thursday, June 10, 2021, ONLINE via Cisco Webex Meetings
Vascular development: a cycle of sprouting, remodeling and maturation
Yale Cardiovascular Research Center, USA
Thursday, May 27, 2021, ONLINE via Cisco Webex Meetings
Hadil El-Sammak
Vegfc signaling promotes coronary revascularization during cardiac regeneration in zebrafish
and
Yohanes Wibowo
The cyclic AMP effector Epac1 is a main endothelial
signaling hub
and
Endothelial Sox9 Is A Master Regulator of Cardiac Fibrosis and Maladaptive Remodeling
Wednesday, May 5, 2021, ONLINE via Cisco Webex Meetings
Immuno-endothelial cross-talk in the liver
and
The role of RNF20 in Vascular Development
Wednesday, April 14, 2021, ONLINE via Cisco Webex Meetings
An acute immune response underlies the benefit of cardiac stem cell therapy
Cincinnati Children's Hospital Medical Center, USA
Thursday, March 11, 2021, Online (Dutch German Meeting)
Dr. Alexey Uvarovskii
Analysis of spatial expression patterns in hepatocytes and endothelial cells
and
Casp8 in endothelial cells is required to maintain intestine homeostasis
and
Photobiomodulation – Influence of blue light on skin cells
Wednesday, March 3, 2021, ONLINE via Cisco Webex Meetings
The many facets of developmental lymphangiogenesis: different cells do different things
University of Münster
Thursday, February 11, 2021, Online via Cisco Webex Meetings
Fat wasting in cancer: the role of endothelial Notch1 signaling
and
Kruppel-like factor 4 (KLF4) is a key determinant in arteriovenous malformation (AVM) pathogenesis
Wednesday, February 3, 2021, ONLINE via Cisco Webex Meetings
The many faces of endoglin in and beyond angiogenesis
Leiden University Medical Center, The Netherlands
Thursday, January 21, 2021, ONLINE via Cisco Webex Meetings
Organ-specific specialization and functional heterogeneity of pericytes
and
Systemic atheroprotection by Stabilin1/2 inhibition
Wednesday, January 13, 2021, ONLINE via Cisco Webex Meetings
The role of endothelial cells in tumor metastasis
Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim
Thursday, December 10, 2020, ONLINE via Cisco Webex Meetings
Endothelial NFAT5-dependent control of lung hypoxia responses
and
microRNA-124a prevents retinal vasoregression in PKD rats
Wednesday, December 2, 2020, ONLINE via Cisco Webex Meetings
How leukocytes open and seal the wall of blood vessels
Endothelial cells regulate macrophage plasticity via Wnt signaling and epigenetic modifications
Department of Pharmacology & Regenerative Medicine, The University of Illinois at Chicago, USA
Thursday, November 12, 2020, ONLINE via Cisco Webex Meetings
Vascular control of tumor immunity in the central nervous system
and
Generation of Human Organoids from adult, normal or malignant Tissue
Wednesday, November 4, 2020, ONLINE via Cisco Webex Meetings
How leukocytes open and seal the wall of blood vessels
Max Planck Institute of Molecular Biomedicine, Muenster
Thursday, October 14, 2020, ONLINE via Cisco Webex Meetings
Aging-associated epigenetic changes in endothelial cells
and
Investigation of extracellular matrix-dependent mechanisms by multiomics Analysis of bladder Cancer 3D in vitro mode
Wednesday, October 7, 2020, ONLINE via Cisco Webex Meetings
BBB tight junctions: the secret door for immune cell entry into the CNS
Theodor Kocher Institute, University of Bern, Switzerland
Thursday, September 10, 2020, ONLINE via Cisco Webex Meetings
Novel insights into endothelial plasticity and signaling
Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main
Thursday, July 16, 2020, ONLINE via Cisco Webex Meeting
1st Joint Summer School and Consortium Meeting 2020
June 22-24, 2019, Heidelberg, Germany
Influence of ABC5+ mesenchymal stem cells on hypoxic damage in vitro and in vivo
and
Endothelial lipidome/transcriptom profile during tumor progression
Wednesday, June 3, 2020, ONLINE via Cisco Webex Meetings
Immune functions and metabolic competence of liver sinusoidal endothelial cells
Institute for Molecular Immunology and Experimental Oncology, Munich
Thursday, May 14, 2020, ONLINE via Cisco Webex Meeting
Dr. Kay Klapproth
Delineating ontogenic and functional heterogeneity of tissue macrophages
and
Dr. Caroline Schreiber
Physiological and pathophysiological roles of ASAP1
Wednesday, May 6, 2020, ONLINE via Cisco Webex Meetings
Vascular Mini-Symposium
April 15, 2020 at the MPI for Heart and Lung Research, Bad Nauheim
was cancelled due to COVID-19
Metabolic regulation of endothelial growth state
MPI for Heart and Lung Research, Bad Nauheim, Germany
Thursday, April 2, 2020, Tridomus, House B, S43, Mannheim
was cancelled due to COVID-19
Targeting of scavanger receptors Stabilin-1 and Stabilin-2 in atherosclerosis
and
Physiological and pathophysiological roles of ASAP1
Wednesday, April 1, 2020, Tridomus, House B, S41, Mannheim
was cancelled due to COVID-19
Role of Lyve-1 during hepatic metastatis of malignant melanoma
and
A human in vitro model of the blood-cerebrospinal fluid barrier to study endo-epithelial as well as host-pathogen interaction
Wednesday, March 4, 2020, Tridomus, House B, S41, Mannheim
Leucocyte migration in tjhe lymphatics - The importance of sugar coating
Radcliffe Department of Medicine, University of Oxford, UK
Thursday, February 13, 2020, 4 pm, Alte Brauerei H02, Röntgenstr. 7, 68167 Mannheim
Revisiting embryonic development: An integrated view of epigenetics and cell commitment
Department of Molecular Cell Biology, Weizmann Institute of Science, Israel
Tuesday, January 21, 2020, 2 pm, ZMBH, Seminar room 001, ground floor, INF 280, Heidelberg
TGFbeta signaling in Cardiovascular development and disease
Wednesday, January 8, 2020, Tridomus, House B, S43, Mannheim
Long non-coding RNAs in endothelial angiogenic function
Vascular Research Center, Goethe University Frankfurt
Thursday, December 12, 2019, 4 pm, Alte Brauerei H02, Röntgenstr. 7, 68167 Mannheim
Angiocrine regulation of metastatic progression
and
Liver sinusoidal endothelial cell-mediated control of innate lymphoid cell function
Wednesday, November, 2019, Tridomus, House B, S41, Mannheim
Iron deficiency aggravates heart failure
Cardiology and Angiology,Hannover Medical School
Thursday, November 14, 2019, 4 pm, Alte Brauerei H02, Röntgenstr. 7, 68167 Mannheim
Pioneering function of Isl1 in epigenetic regulation during second heart field development
and
The role of RNF20 in vascular function
Wednesday, November, 2019, Tridomus, House B, S41, Mannheim
German Society for Microcirculation and
October 25 – 27, 2019, Heidelberg, Germany
Consortium Meeting CRC1366
October 24/25, 2019, Heidelberg, Germany
Ketone bodies induce endothelial cell proliferation
and
Generation of human liver organoids
Wednesday, October, 2019, Tridomus, House B, S41, Mannheim
Apelin signaling switches quiescent vascular endothelial cells into a pro-angiogenic state
Philipps University Marburg
Wednesday, September 18, 2019, Tridomus, House B, S43, Mannheim
Women in Science Symposium
Impediment or Inspiration for a Scientific Career?
Successful Women in Metabolism and Diabetes Research
Thursday, September 12, 2019
Medizinische Klinik Heidelberg University Hospital,
Im Neuenheimer Feld 410, Heidelberg, Germany
Prof. Dr. Hellmut Augustin, Dr. Katharina Schlereth, Prof. Dr. Michael Platten
Blutgefäße – eine Präsentation des CRC1366
Thursday, July 11, 2019, 7:30 pm
Karlstorbahnhof, Am Karlstor 1, 69117 Heidelberg
Metabolic control of cardiovascular disease development and progression
Institute for Cardiovascular Regeneration, Goethe University Frankfurt
Thursday, July 11, 2019, 4 pm, Alte Brauerei H02, Röntgenstr. 7, 68167 Mannheim
Influence of Mesenchymal Stem Cells on HUVEC: Potential Impact for Chronic Limb Ischemia
and
Nicolas Gengenbacher
Targeting Angiopoietin-2 in Advanced Models of Metastasis
Wednesday, July 3, 2019, 12 pm, Tridomus, House B, Room S41, Mannheim
WNT/beta-Catenin transcriptional control of heart remodeling
Developmental Pharmacology group, Institute of Pharmacology and Toxicology,
University Medical Center Goettingen
Tuesday, June 18, 2019, 2 pm, Tridomus, House B, Ebene 2, Room S41, Mannheim
Vascular remodeling by hypoxic natural killer cells
Institute of Anatomy, University of Zürich
Thursday, May 9, 2019, 4 pm, Allte Brauerei H02, Mannheim
Sleeman Group
Id proteins as therapeutic targets in cancer
Wednesday, June 5, 2019, 12 pm, Tridomus, House B, Ebene 2, Room S41
Ludolf-Krehl-Str. 7-11, 68167 Mannheim
Glue and spice, keep your lymphatic vessels nice
European Institute for Molecular Imaging, University of Münster
Thursday, May 9, 2019, 4 pm, Tridomus, House B, Room S43, Ebene 2, Mannheim
Dr. Katharina Schlereth
Epigenetic remodeling is essential for postnatal angiogenesis
and
Angiocrine HGF signaling in the liver
Wednesday, May 8, 2019, 12 pm, Tridomus, House B, Room S43, Mannheim
Wednesday, May 8, 2019, Tridomus, House B, Room S43, Ebene 2
The cystathionine y-lyase and protein sulfhydration/persulfidation
in vascular homeostasis
Institute of Vascular Signaling, Centre for Molecular Medicine,
Goethe University, Frankfurt
Thursday, April 11, 2019, 4 pm, Alte Brauerei, Mannheim
PD Dr. Katja Breitkopf-Heinlein
How BMP-9 modulates the hepatic responses to LPS
and
Dr. Manuel Winkler - AG Goerdt/Koch
Gata4 - master regulator of organ-specific endothelial
specification in the liver
Wednesday, April 3, 2019, 12 pm, Tridomus, House B, Room S41, Mannheim
Dr. Anupriya Chatterjee - AG Feng / Wieland
The Role of O-GlcNAcylation in NDPK-B Deficiency-Correlated Endothelial Damage
and
Dr. Matthias Kolibabka - AG Hammes
Impact of Endothelial Gene Regulation on the Cell-cell communication of the Neurovascular Unit
Wednesday, March 6, 2019, 12 pm, Tridomus, House B, Room S4, Mannheim1
Kickoff Meeting CRC1366
March 1, 2019, Mannheim, Germany
Dr. Soni Pullamsetti
Max Planck Institute for Heart and Lung Research, Bad Nauheim
Transcriptional Regulation and its Misregulation in
Pulmonary Vascular Disease
Thursday, Feb. 21, 2019, 2 pm, Tridomus, House B, Room S41, Mannheim
Prof. Dr. Daniela Wenzel
Physiological Institute I, Bonn University
Mechanisms and Experimental Therapies for the
Regulation of Vascular Tone
Thursday, Feb. 14, 2019, 2 pm, Tridomus, House B, Room S41, Mannheim
Dr. Donato Inverso - AG Augustin
Angiopoietin-Tie Regulation of Organo-specific Angiocrine Wnt Codes
and
Dr. Andromachi Karakatsani - AG Ruiz de Almodóvar
Neurovascular Link in Neurogenic Niches of the Adult Mouse Brain
Wednesday, Feb. 6, 2019, 12 pm, Tridomus, House B, Room S41, Mannheim
Prof. Dr. Katrin Schröder
Vascular Research Centre, Goethe University Frankfurt
Nox4 in Endothelial Function
Monday, Jan. 28, 2019, 1 pm, Tridomus, House B, Room S41, Mannheim
Prof. Dr. Ralf Adams
Max Planck Institute for Molecular Biomedicine, Münster
Organ-specific and Functional Spezialization of Blood Vessels
Thursday, Jan. 10, 2019, 4 pm, Alte Brauerei, lecture hall H02, Mannheim
Consortium Meeting CRC1366
October 24/25, 2019, Heidelberg, Germany
Program