News and Events

Upcoming Events

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Contact

Spokesperson

Prof. Dr. Hellmut G. Augustin

European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg

Vice Spokesperson

Prof. Dr. Sergij Goerdt

University Hospital for Dermatology,

Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim, Heidelberg University

CRC1366/ECAS InSight

for complete schedule 2021 press here

Dr. Katja Breitkopf-Heinlein

Differential BMP-9/ALK1 signalling outcome in human

endothelial and epithelial cell types of gut and liver

Breitkopf-Heinlein Group

and

Lukas Tombor

Endothelial plasticity after myocardial infarct

Dimmeler Group

Wednesday, July 7, 2021, ONLINE via Cisco Webex Meetings

 

 

 

CRC1366/ECAS Seminars in Angioscience

TBA

TBA

TBA

Thursday, July 15, 2021, ONLINE via Cisco Webex Meetings

 
 
Seminar flyer_2021_07_07_Poster.jpg
 

2nd Joint Summer School and

Consortium Meeting 2021 

April 21-23, 2021

DSC00916.jpg
 

News

Mahak Singhal receives the Helmholtz Doctoral Prize 2020

Mahak Singhal from the Augustin Group received the Helmholtz Doctoral Prize 2020

that is awarded by the Helmholtz Association to young researchers who have completed

their doctorate at a Helmholtz Center and obtained outstanding results.

Mahak Singhal received the award for his research on the interface between vascular

biology and tumor biology leading to a better understanding of the mechanisms of

metastasis formation in order to develop new diagnostic and therapeutic methods.

PRESS RELEASE.

Cyrill Géraud receives “Paul-Langerhans-Preis 2021”

Cyrill Géraud receives “Paul-Langerhans-Preis 2021”, which is awarded by the “Arbeitsgemeinschaft Dermatologische Forschung“ (ADF e.V.) to „highly qualified dermatological scientists with continuous, first-class and innovative research activities”.

PRESS RELEASE.

 

Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"

Prof. Dr. Sofia-Iris Bibli receives one of the prestigious Emmy Noether Grants from the German Research Foundation (DFG). Advanced age is the dominant unmodifiable risk factor for cardiovascular diseases and strategies to rejuvenate the senescent endothelium remain far away from the clinic. Metabolic adaptation seems to be the key for the preservation of endothelial homeostasis.  To this end, Prof. Bibli and her team will investigate the role of rewired cysteine metabolism in vascular aging and

regeneration and will be funded to establish an Emmy Noether Group in the Institute for Vascular Signaling at the Goethe University.

In addition, she received the Oskar-Lapp-Prize for her Publication "Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function".

Ralf Adams receives „Feldberg Prize“ 2021

Ralf Adams, Director at the Max Planck Institute for Molecular Biomedicine in Münster, receives the Feldberg Prize 2021, which is awarded annually by the Feldberg Foundation for Anglo-German Scientific Exchange to one researcher in Germany and one in the United Kingdom. The purpose of the Foundation and the prize is the promotion of scientific contact between German and English scientists within the sphere of experimental medical research.

PRESS RELEASE.

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

The research team of Stefanie Dimmeler showed that endothelial cells show transient mesenchymal phenotype after infarct. Single-cell RNA sequencing was used together with in vivo tracing methods to decipher cellular heterogeneity. Remarkably, endothelial cells show a transient mesenchymal phenotype within the first days upon myocardial infarction. However, at later stages, these cells do not acquire a long-term mesenchymal fate. Hence, this process termed as EndMA (Endothelial to Mesenchymal Activation) which might be required for facilitating tissue regeneration.

PRESS RELEASEhttps://doi.org/10.1038/s41467-021-20905-1

Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk

The research team of Carmen Ruiz de Almodóvar provided new evidence that blood vessels can control and regulate organ function. They observed a crosstalk between the neural and the vascular compartment of the developing central nervous system inducing neural progenitor cells to specialize into oligodendrocyte progenitor cells. 

PRESS RELEASEhttps://doi.org/10.1038/s41593-020-00788-z

 

Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling

The research team of Sergij Goerdt, Philipp Reiners-Koch and Cyrill Géraud gained new insights into regulation of liver fibrosis and liver regeneration. They observed that blood vessel malfunction in the liver causes liver dysfunction confirming that blood vessels are able to control organ function as well as disease processes. Furthermore, they identified the GATA4/MYC/PDGFB/PDGFRβ axis as promising therapeutic approach. 

PRESS RELEASEhttps://doi.org/10.1016/j.jhep.2020.08.033

Signaling pathway for tumor spread via lymph vessels discovered

Hellmut Augustin and colleagues from the DKFZ have developed a new animal model to investigate the spread of tumor cells and ways to block the spread of the often fatal colonization. Using an antibody against Ang2 caused lymphatic vessels to die, thereby preventing metastasis and prolonging survival of tumor-bearing mice. With this finding they validated a proof-of-concept for the development of new treatment strategies to prevent the dangerous spreading of tumor cells. 

doi.org/10.1158/2159-8290.CD-20-0122

Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma

Hellmut Augustin and colleagues have identified Ang2-producing tumor cells in a subset of melanoma patients with evident metastases formation. Further studies in mice revealed that tumor cells that produce angiopoietin-2 are protected against cell stress and therefore have an advantage in metastasis.

doi.org/10.1158/0008-5472.CAN-19-2660

Switching off Hif-1 in NK cells slows Tumor growth

Adelheid Cerwenka and colleagues have identified a key molecule that slows down the activity of natural killer cells in tumor defense. Solving this brake could be a promising strategy to improve NK cell-based immunotherapies against solid Tumors.

doi.org/10.1016/j.immuni.2020.05.001

A novel endothelial-specific Receptor Function-Blocking Antibody inhibits Metastasis

Hellmut Augustin and colleagues have succeeded in blocking a rarely studied endothelial-specific receptor with an antibody and thus preventing the formation of metastases in mice with breast or lung cancer. They could demonstrate a new principle how the relocation of cancer cells could be slowed down in the future.

doi.org/10.15252/emmm.201911164

Endothelial Notch Signaling Controls Insulin Transport in Muscle

Andreas Fischer and colleagues have found that in obese mice, a signaling pathway has been stimulated that prevents Insulin from crossing  the endothelial cell layer, a prerequisite for its function, and thus promotes insulin resistance. This result helps to better understand metabolic syndrome and the development of Diabetes.

doi: 10.15252/emmm.201809271. Epub 2020 Mar 18.

Carmen Ruiz de Almodóvar receives ERC Consolidator Grant

for the project "The Oligo-Vascular Interface: Understanding its Properties and Functions"

The group has identified an 'oligo-vascular interface', whereby vessels send out signals to

directly control the generation of oligodendrocyte precursor cells. Her research will focus

on the identification of molecular interactions between blood vessels and oligodendrocytes

during development, homeostasis and in conditions of demyelinating diseases.

The CRC1366 has now 5 PIs from 25 currently holding funded ERC grants.

Press release Nachrichten Informationsdienst Wissenschaft (idw), Dec. 10, 2019

Andreas Fischer receives Gábor Szász Award

for his research on the importance of the endothelium - the cells that line the blood vessels

from the inside - in the spread of cancer. The researchers could show that cancer cells

reprogramm the endothelium thereby increasing the production of a contact molecule that

allows cancer cells to attach to the vessel wall and prepare for passage into the blood vessels.

The activated signaling pathway facilitates cancer cells' access to the bloodstream and metastasis

to other organs and the production of messengers that attract cancer-promoting immune cells

into the tumor.

Press release German Cancer Research Center (DKFZ), Oct. 7, 2019

 

Überlebensstrategien im Klub K: Ein bisschen Maß muss sei

Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019

for more

 

Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten

Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)

 

Bericht im Mannheimer Morgen vom 1. März 2019

Pressemitteilung zum Kickoff Meeting

Michael Platten receives the German Cancer Award 2019

Pressemitteilung vom 23.11.2018

GRÜNES LICHT FÜR NEUEN GEFÄSSBIOLOGISCHEN SONDERFORSCHUNGSBEREICH

Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.

Switching off Hif-1 in NK cells slows Tumor growth

Prof. Cerwenka and colleagues from the German Cancer Research Center (DKFZ), have identified a key molecule that slows down the activity of natural killer cells in tumor defense. Solving this brake could be a promising strategy to improve NK cell-based immunotherapies against solid Tumors.

singhal_edited.jpg

Source: Anspach / DKFZ 

Past Events

Dr. Lothar Dieterich

Lymphatic endothelial regulation of tumor immunity

Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland

Friday, June 18, 2021, ONLINE via Cisco Webex Meetings

Prof. Iris-Sofia Bibli

Endothelial de-CYS-tiny: Cysteinolysis and endothelial cell fates

and

Dr. Victor Olsavszky

Activating β-Catenin mutation in bone marrow sinusoidal endothelium leads to dyserythropoiesis

Wednesday, June 16, 2021, ONLINE via Cisco Webex Meetings

Prof. Elisabetta Dejana

Heterogeneity of endothelial cells in cerebral cavernous malformations

Department of Immunology, Genetics & Pathology, Uppsala University, Sweden

University of Milan, Italy

Thursday, June 10, 2021, ONLINE via Cisco Webex Meetings

Prof. Anne Eichmann

Vascular development: a cycle of sprouting, remodeling and maturation

Yale Cardiovascular Research Center, USA

Thursday, May 27, 2021, ONLINE via Cisco Webex Meetings

Hadil El-Sammak

Vegfc signaling promotes coronary revascularization during cardiac regeneration in zebrafish

and

Yohanes Wibowo

The cyclic AMP effector Epac1 is a main endothelial

signaling hub

and

Dr. Felix Trogisch

Endothelial Sox9 Is A Master Regulator of Cardiac Fibrosis and Maladaptive Remodeling

Wednesday, May 5, 2021, ONLINE via Cisco Webex Meetings

 

Dr. Ana Stojanovic

Immuno-endothelial cross-talk in the liver

and

Nalan Tetik-Elsherbiny

The role of RNF20 in Vascular Development

Wednesday, April 14, 2021, ONLINE via Cisco Webex Meetings

Prof. Jeffery Molkentin

An acute immune response underlies the benefit of cardiac stem cell therapy

Cincinnati Children's Hospital Medical Center, USA

Thursday, March 11, 2021, Online (Dutch German Meeting)

Dr. Alexey Uvarovskii

Analysis of spatial expression patterns in hepatocytes and endothelial cells

and

Dr. Nathalie Tisch

Casp8 in endothelial cells is required to maintain intestine homeostasis

and

Dr. Natalia Kuch

Photobiomodulation – Influence of blue light on skin cells

Wednesday, March 3, 2021, ONLINE via Cisco Webex Meetings

Prof. Stefan Schulte-Merker

The many facets of developmental lymphangiogenesis: different cells do different things

University of Münster

Thursday, February 11, 2021, Online via Cisco Webex Meetings

Dr. Jacqueline Taylor

Fat wasting in cancer: the role of endothelial Notch1 signaling

and

Kuheli Banerjee

Kruppel-like factor 4 (KLF4) is a key determinant in arteriovenous malformation (AVM) pathogenesis

Wednesday, February 3, 2021, ONLINE via Cisco Webex Meetings

Prof. Lukas Hawinkels

The many faces of endoglin in and beyond angiogenesis

Leiden University Medical Center, The Netherlands

Thursday, January 21, 2021ONLINE via Cisco Webex Meetings

 

Dr. Seyed Javad Rasouli

Organ-specific specialization and functional heterogeneity of pericytes

and

Dr. Thomas Leibing

Systemic atheroprotection by Stabilin1/2 inhibition

Wednesday, January 13, 2021, ONLINE via Cisco Webex Meetings

 

Dr. Boris Strilic

The role of endothelial cells in tumor metastasis

Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim

Thursday, December 10, 2020, ONLINE via Cisco Webex Meetings

 

Dr. Hebatullah Laban

Endothelial NFAT5-dependent control of lung hypoxia responses

and

Jihong Lin

microRNA-124a prevents retinal vasoregression in PKD rats

Wednesday, December 2, 2020, ONLINE via Cisco Webex Meetings

Prof. Asrar B. Malik

How leukocytes open and seal the wall of blood vessels

Endothelial cells regulate macrophage plasticity via Wnt signaling and epigenetic modifications

Department of Pharmacology & Regenerative Medicine, The University of Illinois at Chicago, USA

Thursday, November 12, 2020, ONLINE via Cisco Webex Meetings

Dr. Katrin Huck

Vascular control of tumor immunity in the central nervous system

and

Dr. Haristi Gaitantzi

Generation of Human Organoids from adult, normal or malignant Tissue

Wednesday, November 4, 2020, ONLINE via Cisco Webex Meetings

 

Prof. Dr. Dietmar Vestweber

How leukocytes open and seal the wall of blood vessels

Max Planck Institute of Molecular Biomedicine, Muenster

Thursday, October 14, 2020, ONLINE via Cisco Webex Meetings

 

Dr. Katharina Schlereth

Aging-associated epigenetic changes in endothelial cells

and

Sarah Wahby

Investigation of extracellular matrix-dependent mechanisms by multiomics Analysis of bladder Cancer 3D in vitro mode

Wednesday, October 7, 2020, ONLINE via Cisco Webex Meetings

 

Prof. Dr. Britta Engelhardt

BBB tight junctions: the secret door for immune cell entry into the CNS

Theodor Kocher Institute, University of Bern, Switzerland

Thursday, September 10, 2020, ONLINE via Cisco Webex Meetings

Prof. Dr. Stefanie Dimmeler

Novel insights into endothelial plasticity and signaling

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Thursday, July 16, 2020, ONLINE via Cisco Webex Meeting

1st Joint Summer School and Consortium Meeting 2020

June 22-24, 2019, Heidelberg, Germany

Program Summer School

Program Consortium Meeting

 

Kaixuan Yan

Influence of ABC5+ mesenchymal stem cells on hypoxic damage in vitro and in vivo

and

Dr. Miki Kamiyama

Endothelial lipidome/transcriptom profile during tumor progression

Wednesday, June 3, 2020, ONLINE via Cisco Webex Meetings

 

Prof. Dr. Percy Knolle

Immune functions and metabolic competence of liver sinusoidal endothelial cells

Institute for Molecular Immunology and Experimental Oncology, Munich

Thursday, May 14, 2020, ONLINE via Cisco Webex Meeting

Dr. Kay Klapproth

Delineating ontogenic and functional heterogeneity of tissue macrophages

and

Dr. Caroline Schreiber

Physiological and pathophysiological roles of ASAP1

Wednesday, May 6, 2020, ONLINE via Cisco Webex Meetings

Vascular Mini-Symposium 

April 15, 2020 at the MPI for Heart and Lung Research, Bad Nauheim

was cancelled due to COVID-19

 

Dr. Michael Potente

Metabolic regulation of endothelial growth state

MPI for Heart and Lung Research, Bad Nauheim, Germany

Thursday, April 2, 2020, Tridomus, House B, S43, Mannheim

was cancelled due to COVID-19

Thomas Leibing

Targeting of scavanger receptors Stabilin-1 and Stabilin-2 in atherosclerosis

and

Caroline Schreiber

Physiological and pathophysiological roles of ASAP1 

Wednesday, April 1, 2020, Tridomus, House B, S41, Mannheim

was cancelled due to COVID-19

Anna Jauch

Role of Lyve-1 during hepatic metastatis of malignant melanoma

and

PD Dr. Walter Muranyi

A human in vitro model of the blood-cerebrospinal fluid barrier to study endo-epithelial as well as host-pathogen interaction

Wednesday, March 4, 2020, Tridomus, House B, S41, Mannheim

Prof. Dr. David Jackson

Leucocyte migration in tjhe lymphatics - The importance of sugar coating

Radcliffe Department of Medicine, University of Oxford, UK

Thursday, February 13, 2020, 4 pm, Alte Brauerei H02, Röntgenstr. 7, 68167 Mannheim

Dr. Yonatan Stelzer

Revisiting embryonic development: An integrated view of epigenetics and cell commitment

Department of Molecular Cell Biology, Weizmann Institute of Science, Israel

Tuesday, January 21, 2020, 2 pm, ZMBH, Seminar room 001, ground floor, INF 280, Heidelberg

Roxana Ola, PhD

TGFbeta signaling in Cardiovascular development and disease

Wednesday, January 8, 2020, Tridomus, House B, S43, Mannheim

Prof. Dr. Ralf Brandes

Long non-coding RNAs in endothelial angiogenic function

Vascular Research Center, Goethe University Frankfurt

Thursday, December 12, 2019, 4 pm, Alte Brauerei H02, Röntgenstr. 7, 68167 Mannheim

 

Mahak Singhal

Angiocrine regulation of metastatic progression

and

Jia-Xiang See

Liver sinusoidal endothelial cell-mediated control of innate lymphoid cell function

Wednesday, November, 2019, Tridomus, House B, S41, Mannheim

 

Prof. Dr. Tibor Kempf

Iron deficiency aggravates heart failure

Cardiology and Angiology,Hannover Medical School

Thursday, November 14, 2019, 4 pm, Alte Brauerei H02, Röntgenstr. 7, 68167 Mannheim

Rui Gao

Pioneering function of Isl1 in epigenetic regulation during second heart field development

and

Nalan Tetik

The role of RNF20 in vascular function

Wednesday, November, 2019, Tridomus, House B, S41, Mannheim

German Society for Microcirculation and

Vascular Biology Meeting 2019

October 25 – 27, 2019, Heidelberg, Germany

Consortium Meeting CRC1366

October 24/25, 2019, Heidelberg, Germany

Program

Eva-Maria Weis

Ketone bodies induce endothelial cell proliferation

and

Haristi Gaitantzi

Generation of human liver organoids

Wednesday, October, 2019, Tridomus, House B, S41, Mannheim

 

Prof. Dr. Christian Helker

Apelin signaling switches quiescent vascular endothelial cells into a pro-angiogenic state

Philipps University Marburg

Wednesday, September 18, 2019, Tridomus, House B, S43, Mannheim

Women in Science Symposium

Impediment or Inspiration for a Scientific Career?

Successful Women in Metabolism and Diabetes Research

Thursday, September 12, 2019

Medizinische Klinik Heidelberg University Hospital,

Im Neuenheimer Feld 410, Heidelberg, Germany

for more information see...

Prof. Dr. Hellmut AugustinDr. Katharina Schlereth, Prof. Dr. Michael Platten

Blutgefäße – eine Präsentation des CRC1366

Thursday, July 11, 2019,  7:30 pm

Karlstorbahnhof, Am Karlstor 1, 69117 Heidelberg 

 

Prof. Dr. Jaya Krishnan

Metabolic control of cardiovascular disease development and progression

Institute for Cardiovascular Regeneration, Goethe University Frankfurt

Thursday, July 11, 2019, 4 pm, Alte Brauerei H02, Röntgenstr. 7, 68167 Mannheim

 

Dr. Prama Pallavi

Influence of Mesenchymal Stem Cells on HUVEC: Potential Impact for Chronic Limb Ischemia

and

Nicolas Gengenbacher

Targeting Angiopoietin-2 in Advanced Models of Metastasis

Wednesday, July 3, 2019, 12 pm, Tridomus, House B, Room S41, Mannheim

 

Dr. Laura Zelarayan

WNT/beta-Catenin transcriptional control of heart remodeling

Developmental Pharmacology group, Institute of Pharmacology and Toxicology,

University Medical Center Goettingen

Tuesday, June 18, 2019, 2 pm, Tridomus, House B, Ebene 2, Room S41, Mannheim 

Prof. Dr. Christian Stockmann

Vascular remodeling by hypoxic natural killer cells

Institute of Anatomy, University of Zürich

Thursday, May 9, 2019, 4 pm, Allte Brauerei H02Mannheim

 

Dr. Georg Sedlmeier

Sleeman Group

Id proteins as therapeutic targets in cancer

Wednesday, June 5, 2019, 12 pm, Tridomus, House B, Ebene 2, Room S41

Ludolf-Krehl-Str. 7-11, 68167 Mannheim 

Prof. Dr. Friedemann Kiefer

Glue and spice, keep your lymphatic vessels nice

European Institute for Molecular Imaging, University of Münster

Thursday, May 9, 2019, 4 pm, Tridomus, House B, Room S43,   Ebene 2, Mannheim

Dr. Katharina Schlereth
Epigenetic remodeling is essential for postnatal angiogenesis

and

Dr. Victor Olsavszky

Angiocrine HGF signaling in the liver

Wednesday, May 8, 2019, 12 pm, Tridomus, House B, Room S43, Mannheim

 

Wednesday, May 8, 2019, Tridomus, House B, Room S43,   Ebene 2

Prof. Dr. Ingrid Fleming

The cystathionine y-lyase and protein sulfhydration/persulfidation

in vascular homeostasis

Institute of Vascular Signaling, Centre for Molecular Medicine, 

Goethe University, Frankfurt

Thursday, April 11, 2019, 4 pm, Alte Brauerei, Mannheim

PD Dr. Katja Breitkopf-Heinlein

How BMP-9 modulates the hepatic responses to LPS

and

Dr. Manuel Winkler - AG Goerdt/Koch

Gata4 - master regulator of organ-specific endothelial

specification in the liver

Wednesday, April 3, 2019, 12 pm, Tridomus, House B, Room S41, Mannheim

Dr. Anupriya Chatterjee - AG Feng / Wieland

The Role of O-GlcNAcylation in NDPK-B Deficiency-Correlated Endothelial Damage

and

Dr. Matthias Kolibabka -  AG Hammes

Impact of Endothelial Gene Regulation on the Cell-cell communication of the Neurovascular Unit

Wednesday, March 6, 2019, 12 pm, Tridomus, House B, Room S4, Mannheim1

 

Kickoff Meeting CRC1366

March 1, 2019, Mannheim, Germany

Flyer

Program

 
Dr. Soni Pullamsetti
Max Planck Institute for Heart and Lung Research, Bad Nauheim
Transcriptional Regulation and its Misregulation in
Pulmonary Vascular Disease
Thursday, Feb. 21, 2019, 2 pm, Tridomus, House B, Room S41, Mannheim
Prof. Dr. Daniela Wenzel
Physiological Institute I, Bonn University
Mechanisms and Experimental Therapies for the
Regulation of Vascular Tone
Thursday, Feb. 14, 2019, 2 pm, Tridomus, House B, Room S41, Mannheim
 
Dr. Donato Inverso - AG Augustin
Angiopoietin-Tie Regulation of Organo-specific Angiocrine Wnt Codes
and
Dr. Andromachi Karakatsani - AG Ruiz de Almodóvar
Neurovascular Link in Neurogenic Niches of the Adult Mouse Brain
Wednesday, Feb. 6, 2019, 12 pm, Tridomus, House B, Room S41, Mannheim
Prof. Dr. Katrin Schröder
Vascular Research Centre, Goethe University Frankfurt
Nox4 in Endothelial Function
Monday, Jan. 28, 2019, 1 pm, Tridomus, House B, Room S41, Mannheim
Prof. Dr. Ralf Adams
Max Planck Institute for Molecular Biomedicine, Münster
Organ-specific and Functional Spezialization of Blood Vessels
Thursday, Jan. 10, 2019, 4 pm, Alte Brauerei, lecture hall H02, Mannheim

Consortium Meeting CRC1366

October 24/25, 2019, Heidelberg, Germany

Program