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CRC1366

Vascular Control of Organ Function

Prof. Dr. Philipp-Sebastian Reiners-Koch

Department of Dermatology, Venereology and Allergy
University Medical Center Mannheim and European Center for Angioscience

Medical Faculty Mannheim, Heidelberg University

philipp.koch(at)umm.de

Professional Career

Since 2018

Co-Group Leader

‘Angiodiversity and Organfunction’ Laboratory, University Medical Center Mannheim, Heidelberg University, Germany

since 10/2017

Senior Physician (Oberarzt)

and Deputy Head of the Section for Dermatosurgery

Department of Dermatology, Venereology, and Allergy

University Medical Center Mannheim, Heidelberg University, Germany

08/2016

Senior Resident Physician (Funktionsoberarzt)

and Deputy Head of the Section for Dermatosurgery

Department of Dermatology, Venereology, and Allergy

University Medical Center Mannheim, Heidelberg University, Germany

2001 - 2016

Resident Physician

Department of Dermatology, Venereology, and Allergy

University Medical Center Mannheim, Heidelberg University, Germany

2011

MD

Institute of Anatomy and Cell Biology

Justus-Liebig-University Giessen, Germany

Selected Publications

Heil J*, Olsavszky V*, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber J, Zierow J, Winkler M, Schmid CD, Staniczek S, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S*, Koch PS*: Bone marrow sinusoidal endothelium
controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun, 12:6963, 2021. (*equal contribution)

Koch PS*, Sandorski K*, Heil J, Schmid CD, Kürschner SW, Hoffmann J, Winkler M, Staniczek T, De La Torre C, Sticht C, Schled-zewski K, Taketo MM, Trogisch F, Heineke J, Géraud C, Goerdt S, Olsavszky V: Imbalanced activation of Wnt-/β-catenin-signaling in liver endothelium alters normal sinusoidal differentiation. Front Physiol, 29;12:722394, 2021. (*equal contribution)

Koch PS*, Lee KH*, Goerdt S, Augustin HG: Angiodiversity and organotypic functions of sinusoidal endothelial cells. Angio-genesis, 24:289-310, 2021. (*equal contribution)

Winkler M*, Staniczek T*, Kürschner SW*, Schmid CD*, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C*, Koch PS*, Goerdt S*: Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol, 74:380-93, 2021. (*equal contribution)

Ni J*, Wang X*, Stojanovic A*, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A: Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. Immunity, 52:1075-87, 2020. (*equal contribution)

Wohlfeil SA*, Häfele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Mohammadi MM, Heineke J, Sticht C, Olsavszky V, Koch PS, Géraud C*, Goerdt S*: Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res, 79:598-610, 2019. (*equal contribution)

Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schled-zewski K, Goerdt S, Koch PS: Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology, 68:707-22, 2018. (*equal contribution).

Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest, 127:1099-114, 2017. (*equal contribution)

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood, 129:415-9, 2017. (*equal contribution)

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