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Upcoming Seminars

CRC1366 / ECAS InSight

TBA

and

TBA

Wednesday, May 8, 2024

CRC1366 / ECAS Seminars in Angioscience

Prof. Axel Roers

Heidelberg University Hospital, University of Heidelberg, Germany

Thursday, June 6, 2024

Events

International Meeting on Vascular Control of Organ Function

May 13-15, 2024,

Alte Brauerei, Mannheim | GER

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International Vascular Biology Meeting 2024

July 2-5, 2024,

Amsterdam| NL

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CRC1366 Fall School & Consortium Meeting (internal)

October 7-9, 2024,

Frankfurt am Main| GER

Publications

Jeong M, Cortopassi F, See JX et al.

Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation.

Eur J Immunol. 2024 April 9.

Trogisch FA, Abouissa A, Keles M et al.

Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9.

Sci Transl Med. 2024 February 28.

Drekolia MK, Karantanou C, Wittig I et al.

Loss of cardiac mitochondrial complex I persulfidation impairs NAD+ homeostasis in aging.

Redox Biol. 2024 February.

The extended role of blood vessels

Blood vessels form a systemically disseminated organ that distributes oxygen and nutrients and removes metabolic waste products. A dense network of microvessels facilitates the trafficking of immune cells throughout the body. Yet, blood vessels do not just support rheological functions. They form one of the body’s largest surfaces serving as critical interface between the circulation and the different organ environments.

Work pursued in the last couple of years has identified critical gatekeeper functions of tissue homeostasis and adaptation to pathologic challenge. It is now increasingly recognized that vascular control of the tissue microenvironment is indispensable in development, homeostasis, inflammation, and metabolism as well as cancer and metastasis. This multitude of vascular functions is mediated by organ-specifically differentiated endothelial and mural cells, whose cellular and molecular heterogeneity has long been recognized.

Yet, distinct organotypic functional attributes as well as the molecular mechanisms controlling endothelial and mural cell differentiation and vascular bed-specific functions have only recently been uncovered. The Collaborative Research Center (CRC) 1366 “Vascular Control of Organ Function” aims at systematically studying gatekeeper functions of organotypically differentiated endothelial and mural cells during development and regeneration.

Überlebensstrategien - Blutgefäße für ein langes Leben

“Überlebensstrategien” is a joint project of the Life Science Collaborative Research Centers of Heidelberg University and Rhein-Neckar Fernsehen (RNF). In an informal setting at the Karlstorbahnhof in Heidelberg and with musical accompaniment by members of the Collegium Musicum, the Collaborative Research Centres will present their questions and long-term goals.

On October 14, 2021, Prof. Hellmut Augustin, Prof. Maliha Sadick and Prof. Andreas Fischer gave a public presentation on “Gesunde Blutgefäße für ein langes Leben” (Healthy blood vessels for a long life). The presentation is only available in German.

News

The CRC1366 “Vascular Control of Organ Function” at Heidelberg University will continue its successful work for another four years

Press release Medical Faculty Mannheim, Heidelberg University, November 2022

Press release Heidelberg University, November 2022

Mahak Singhal receives the Helmholtz Doctoral Prize 2020

Press release Medical Faculty Mannheim University Heidelberg, May 2021

Didier Stainier receives ERC Advanced Grant

Max Planck Institute for Heart and Lung Research, Bad Nauheim, April 2021

Cyrill Géraud receives "Paul Langerhans-Pize" 2021

Press release Medical Faculty Mannheim University Heidelberg, April 2021

Sofia-Iris Bibli receives "Emmy Noether Grant" and "Oskar-Lapp-Prize"

Institute of Vascular Signaling, Center for Molecular Medicine, Goethe University Frankfurt, April 2021

Ralf Adams receives „Feldberg Prize“ 2021

Press release Max Planck Institute for Molecular Biomedicine, Münster, February 01, 2021

Blood vessels control organ function and disease processes

Press release Medical Faculty Mannheim University Heidelberg, December 04,2020

Lymphatics prevent spreading of cancer cells

Press release German Cancer Research Center (DKFZ), October 26, 2020

Endothelial cell-specific factor protects metastatic tumor cells

Press release German Cancer Research Center (DKFZ), May 26, 2020

HIF-1α decelerates natural Killer cells

Press release Medical Faculty Mannheim University Heidelberg May 22, 2020

Prevent metastasis - an antibody with potential

Press release German Cancer Research Center (DKFZ), April 24, 2020

The role of blood vessels in insulin resistance

Press release German Cancer Research Center (DKFZ), March 27, 2020

Carmen Ruiz de Almodóvar receives ERC Consolidator Grant

Press release Medical Faculty Mannheim University Heidelberg Dec. 10, 2019

Andreas Fischer receives Gábor Szász Award

Press release German Cancer Research Center (DKFZ), Oct. 7, 2019

Überlebensstrategien im Klub K: Ein bisschen Maß muss sein

Zeitungsartikel der Rhein-Neckar Zeitung vom 13. Juli 2019

for more

Blutgefäße spielen bei einer Krebserkrankung eine wichtige Rolle: Sie ermöglichen es den Tumoren, zu wachsen und sich im Körper auszubreiten

Pressemitteilung des Deutschen Krebsforschungszentrums (DKFZ)

Bericht im Mannheimer Morgen vom 1. März 2019

Pressemitteilung zum Kickoff Meeting

Michael Platten receives the German Cancer Award 2019

Bericht im Mannheimer Morgen vom 2. März 2019

Pressemitteilung vom 23.11.2018

Grünes Licht für neuen gefäßbiologischen Sonderforschungsbereich

Die Deutsche Forschungsgemeinschaft (DFG) fördert die Erforschung von Mechanismen, mit denen Blutgefäße die Funktion von Organen während der Entwicklung und bei Krankheitsprozessen steuern, mit mehr als 11 Mio. Euro.

CRC1366

Vas­cular Control of Organ Function