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Prof. Dr. Sergij Goerdt

Project B02

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Department of Dermatology, Venereology and Allergy,
University Medical Center Mannheim and European Center for Angioscience

Medical Faculty Mannheim, Heidelberg University

sergij.goerdt(at)medma.uni-heidelberg.de

Professional Career

Since 2015

Dean

​Medical Faculty Mannheim, Heidelberg University, Germany

2013 - 2015

Vice Dean

​ Medical Faculty Mannheim, Heidelberg University, Germany

2006 - 2010

Vice Dean for Structure and Development

​Medical Faculty Mannheim, Heidelberg
University, Germany

Since 2000

Chairman and Head

 Dept. of Dermatology, Venereology, and Allergy

University Medical Center and Medical Faculty Mannheim

Heidelberg University, Germany

1997

University Professor

for Dermatology and Venereology, Freie Uiveristät Berlin, Germany

1995 - 2000

Vice Chairman

 Dept. of Dermatology, Freie Universität Berlin, Germany

1994 - 1995

Consultant

Dept. of Dermatology, Freie Universität Berlin, Germany

1991 - 1994

Senior Resident

 Dept. of Dermatology, University of Münster, Germany

1989 - 1991

Visiting Research Fellow

Harvard Medical School, Boston, USA

1987 - 1989

Resident

 Dept. of Dermatology, University of Münster, Germany

1987

MD

University of Münster, Germany

Selected Publications

Heil J*, Olsavszky V*, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber J, Zierow J, Winkler M, Schmid CD, Staniczek S, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S*, Koch PS*: Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun, 12:6963, 2021. (*equal contribution)


Winkler M*, Staniczek T*, Kürschner SW*, Schmid CD*, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C*, Koch PS*, Goerdt S*: Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol, 74:380-93, 2021. (*equal contribution)


Wohlfeil SA*, Hafele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Mohammadi MM, Heineke J, Sticht C, Olsavszky V, Koch PS, Geraud C*, Goerdt S*: Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res, 79:598-610, 2019. (*equal contribution)
 

Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest, 127:1099-114, 2017. (*equal contribution)
 

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood, 129: 415-9, 2017. (*equal contribution)
 

Schledzewski K, Géraud C, Arnold B, Wang S, Gröne HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schönhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S: Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest, 121:703-14, 2011.
 

Géraud C*, Schledzewski K*, Demory A, Klein D, Kaus M, Peyre F, Sticht C, Evdokimov K, Lu S, Schmieder A, Goerdt S: Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Hepatology, 52:313-26, 2010. (*equal contribution)
 

Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J, Schledzewski K, Arnold B, Goerdt S: Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology, 47:1018-31, 2008.
 

Kzhyshkowska J, Mamidi S, Gratchev A, Kremmer E, Schmuttermaier C, Krusell L, Haus G, Utikal J, Schledzewski K, Scholtze J, Goerdt S: Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood. 107: 3221-8, 2006.
 

Goerdt S, Orfanos CE: Other functions, other genes: alternative activation of antigen-presenting cells. Immunity. 10:137-42, 1999.

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