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Dr. Chi-Chung Wu

Project A04

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European Center for Angioscience

Medical Faculty Mannheim, Heidelberg University

Chi-Chung.Wu(at)medma.uni-heidelberg.de

Professional Career

Since 2021

Junior Research Group Leader

European Center for Angioscience

Medical Faculty Mannheim, Heidelberg University

2016 - 2021

Postdoctoral Fellow

Max Planck Institute for Heart and Lung Research

Bad Nauheim, Germany

2016

Ph.D.

University of Ulm, Germany

Selected Publications

Bertozzi A, Wu CC, Hans S, Brand M, Weidinger G: Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. Dev Biol, 481:226-37, 2022.

Bertozzi A*, Wu CC*, Dalvoy M, Nguyen P, Koopman C, de Boer T, Bakkers J, Weidinger G: Is zebrafish heart regeneration ‘complete’? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts. Dev Biol, 471:106-18, 2021. (*equal contribution)

Wu CC#, Jeratsch S, Graumann J, Stainier DYR#: Modulation of mammalian cardiomyocyte cytokinesis by the extracellular matrix. Circ Res, 127:896-907, 2020. (#Corresponding authors)

Beisaw A, Kuenne C, Günther S, Dallmann S, Wu CC, Bentsen M, Looso B, Stainier DYR: AP-1 contributes to chromatin accessibility to promote sarcomere disassembly and cardiomyocyte protrusion during zebrafish heart regeneration. Circ Res, 126:1760-78, 2020.

Wu CC*, Kruse F*, Dalvoy M, Junker JP, Zebrowski DC, Fischer K, Noël ES, Grün D, Berezikov E, Engel FB, van Oudenaarden A, Weidinger G, Bakkers J: Spatially-resolved genome-wide transcriptional profiling identifies BMP signaling as essential regulator of zebrafish cardiomyocyte regeneration. Dev Cell, 36:36-49, 2016. (*equal contribution)

Wu CC, Weidinger G: Cardiac regeneration in zebrafish Regenerative Medicine: from Protocol to Patient – Biology of Tissue Regeneration, 3rd edition:307-37, 2016.

Zebrowski DC, Vergarajauregui S, Wu CC, Piatkowski T, Becker R, Leone M, Hirth S, Ricciardi F, Falk N, Giessl A, Just S, Braun T, Weidinger G, Engel FB: Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. eLife, 4:e05563, 2015.

Wu CC, Weidinger G: Zebrafish as a model for studying cardiac regeneration. Curr Pathobiol Rep, 2:93-100, 2014.

Schnabel K*, Wu CC*, Kurth T, Weidinger G: Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation. PLoS One, 6:e18503, 2011. (*equal contribution)

Chan WM, Tsoi H, Wu CC, Wong CH, Cheng TC, Li HY, Lau KF, Shaw PC, Perrimon N, Chan HYE: Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Hum Mol Genet, 20:1738-50, 2011.

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