CRC1366
Vascular Control of Organ Function
Prof. Dr. Thomas Wieland
Chairman, Experimental Pharmacology and Dean of Studies
European Center for Angioscience,
Medical Faculty Mannheim, Heidelberg University
Professional Career
Since 2015
Dean of Studies
Medical Faculty Mannheim, Heidelberg University
Since 2002
Full Professor
Institute of Experimental and Clinical Pharmacology and Toxicology
Heidelberg University, Germany
1997 - 2002
Full Professor
Institute of Experimental and Clinical Pharmacology and Toxicology
University of Hamburg, Germany
1991 - 1996
Post-doctoral Scholar
Department of Pharmacology, University of Duisburg-Essen, Germany
1990 - 1991
Post-doctoral Scholar
Department of Pharmacology, University of Heidelberg, Germany
1989
Ph.D.
in Pharmacology
Selected Publications
Felix I, Lomada SK, Barth H, Wieland T: Bacillus anthracis' PA63 Delivers the Tumor Metastasis Suppressor Protein NDPK-A/NME1 into Breast Cancer Cells. Int J Mol Sci, 21:3295, 2020.
Abu-Taha IH, Heijman J, Feng Y, Vettel C, Dobrev D, Wieland T: Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update. Lab Invest, 98:190-197, 2018.
Garg J, Feng YX, Jansen SR, Friedrich J, Lezoualc'h F, Schmidt M, Wieland T: Catecholamines facilitate VEGF-dependent angiogenesis via β2-adrenoceptor-induced Epac1 and PKA activation. Oncotarget, 8:44732-44748, 2017.
Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz C, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus, HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T: Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation, 135:881-97, 2017.
Zhou XB, Feng YX, Sun Q, Lukowski R, Qiu Y, Spiger K, Li Z, Ruth P, Korth M, Skolnik EY, Borggrefe M, Dobrev D, Wieland T: Nucleoside diphosphate kinase B-activated intermediate conductance potassium channels are critical for neointima formation in mouse carotid arteries. Arterioscler Thromb Vasc Biol, 35:1852-61, 2015.
Feng Y, Gross S, Wolf NM, Butenschön VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes HP, Wieland T: Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins. Arterioscler Thromb Vasc Biol, 34:2292-300, 2014.
Hippe HJ, Wolf NM, Abu-Taha I, Mehringer R, Just S, Lutz S, Niroomand F, Postel EH, Katus HA, Rottbauer W, Wieland T: The interaction of nucleoside diphosphate kinase B with Gbg dimers controls heterotrimeric G protein function. Proc Natl Acad Sci USA, 106:16269-74, 2009.
Hippe HJ, Luedde M, Lutz S, Koehler H, Eschenhagen T, Frey N, Katus HA, Niroomand F, Wieland T: Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein bg dimer complexes. Circ Res, 100:1191-9, 2007.
Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ: Structure of Gaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318:1923-7, 2007.
Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T: The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. J Biol Chem, 280:11134-9, 2005.