CRC1366
Vascular Control of Organ Function
Prof. Dr. Thomas Korff
Medical Faculty Heidelberg and
European Center for Angioscience,
Medical Faculty Mannheim, Heidelberg University
Professional Career
2013
Adjunct Professor
Since 2005
Group Head
Blood Vessel Remodeling, Insitute of Physiology and Pathophysiology
Heidelberg University, Germany
2003 - 2005
Junior Professor
Department od Cardiovascular Physiology
University of Göttingen, Germany
2001 - 2003
Junior Group Leader
Department of Vascular Biology & Angiogenesis Research,
Tumor Biology Center, Freiburg, Germany
2000 - 2001
Post-doctoral Associate
Cell Biology Laboratory, Department of Obstetrics and Gynecology
University of Göttingen
1996 - 1999
Graduate Student
Cell Biology Laboratory, Department of Obstetrics and Gynecology
University of Göttingen
Selected Publications
Jäger MA, De La Torre C, Arnold C, Kohlhaas J, Kappert L, Hecker M, Feldner A, Korff T: Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res, 388:111782, 2020.
Arnold C, Feldner A, Zappe M, Komljenovic D, De La Torre C, Ruzicka P, Hecker M, Neuhofer W, Korff T: Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J, 33:3364-3377, 2019.
Zappe M, Feldner A, Arnold C, Sticht C, Hecker M, Korff T: NFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells. Front Physiol, 9:1190, 2018.
Kuk H, Arnold C, Wagner AH, Hecker M, Sticht C, Korff T: Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice. Front Physiol, 9:320, 2018.
Arnold C, Demirel E, Feldner A, Genové G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T: Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J, 32:2021-35, 2018.
Eschrich J, Meyer R, Kuk H, Wagner AH, Noppeney T, Debus S, Hecker M, Korff T: Varicose remodeling of veins is suppressed by 3-hydroxy-3-methylglutaryl coenzyme A reductase Inhibitors. J Am Heart Assoc, 5:e002405, 2016.
Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T: Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc, 3:e000626, 2014.
Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T: RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med, 6:993-1104, 2014.
Demicheva E, Hecker M, Korff T: Stretch-induced activation of the transcription factor activator protein-1 controls monocyte chemoattractant protein-1 expression during arteriogenesis. Circ Res, 103:477-84, 2008.
Korff T, Braun J, Pfaff D, Augustin H and Hecker M: Role of ephrinB2 in endothelial cells during arteriogenesis: Impact on smooth muscle cell migration and monocyte recruitment. Blood, 112:73-81, 2008.