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Prof. Dr. Thomas Korff

Project B05

Medical Faculty Heidelberg and

European Center for Angioscience,

Medical Faculty Mannheim, Heidelberg University

Professional Career


Adjunct Professor

Since 2005

Group Head

Blood Vessel Remodeling, Insitute of Physiology and Pathophysiology

Heidelberg University, Germany

2003 - 2005

Junior Professor

Department od Cardiovascular Physiology

University of Göttingen, Germany

2001 - 2003

Junior Group Leader

Department of Vascular Biology & Angiogenesis Research,

Tumor Biology Center, Freiburg, Germany

2000 - 2001

Post-doctoral Associate

Cell Biology Laboratory, Department of Obstetrics and Gynecology

University of Göttingen

1996 - 1999

Graduate Student

Cell Biology Laboratory, Department of Obstetrics and Gynecology

University of Göttingen

Selected Publications

ger MA, De La Torre C, Arnold C, Kohlhaas J, Kappert L, Hecker M, Feldner A, Korff T: Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res, 388:111782, 2020.

Arnold C, Feldner A, Zappe M, Komljenovic D, De La Torre C, Ruzicka P, Hecker M, Neuhofer W, Korff T: Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J, 33:3364-3377, 2019.

Zappe M, Feldner A, Arnold C, Sticht C, Hecker M, Korff T: NFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells. Front Physiol, 9:1190, 2018.

Kuk H, Arnold C, Wagner AH, Hecker M, Sticht C, Korff T: Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice. Front Physiol, 9:320, 2018.

Arnold C, Demirel E, Feldner A, Genové G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T: Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J, 32:2021-35, 2018.

Eschrich J, Meyer R, Kuk H, Wagner AH, Noppeney T, Debus S, Hecker M, Korff T: Varicose remodeling of veins is suppressed by 3-hydroxy-3-methylglutaryl coenzyme A reductase Inhibitors. J Am Heart Assoc, 5:e002405, 2016.

Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T: Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc, 3:e000626, 2014.

Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T: RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med, 6:993-1104, 2014.

Demicheva E, Hecker M, Korff T: Stretch-induced activation of the transcription factor activator protein-1 controls monocyte chemoattractant protein-1 expression during arteriogenesis. Circ Res, 103:477-84, 2008.

Korff T, Braun J, Pfaff D, Augustin H and Hecker M: Role of ephrinB2 in endothelial cells during arteriogenesis: Impact on smooth muscle cell migration and monocyte recruitment. Blood, 112:73-81, 2008.

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