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Prof. Dr. Carmen Ruiz de Almodóvar

Project A02

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Institute for Neurovascular Cell Biology

University Hospital Bonn

carmen.ruizdealmodovar(at)uni-bonn.de

Professional Career

Since 2022

W3 Schlegel Chair and Professorship

 for Neurovascular Cell Biology

University of Bonn, Germany

2018 - 2022

W3 Professor

Vascular Dysfunction, Medical Faculty Mannheim

University of Heidelberg, German

2011 - 2018

Junior Group Leader

Biochemistry Center, University of Heidelberg, Germany

2004 - 2011

Postdoctoral Fellow

Vesalius Research Center, VIB-KU Leuven, Belgium

2004

PhD in Biochemistry

Biochemistry and Molecular Biology

University of Granada, Spain

Selected Publications

Shen Y, Wang X*, Liu Y, Singhal M, Gurkaslar C, Freire-Valls A, Leis Y, Hu W, Schermann G, Adler H, Xu FY, Fischer T, Zhu Y, Augustin HG, Schmidt T*, Ruiz de Almodovar C*: STAT3-YAP/TAZ signaling in endothelial cells regulates tumor angiogenesis. Sci Signal, 14:eabj8393. 2021. (*equal contribution)


Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D`Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodovar C: The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep, 36:109522, 2021.


Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C: Oligodendrocyte precursor cell specification is regulated by bi-directional neural progenitor-endothelial cell crosstalk. Nat Neurosci, 24:478-88, 2021.


Tisch N, Ruiz de Almodóvar C: Contribution of cell death signaling to blood vessel formation. Cell Mol Life Sci, 78:3247-64, 2021.
 

Luck R*, Urban S*, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, Ruiz de Almodóvar C: VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. eLife, 8:e49818, 2019. (*equal contribution)


Tisch N*, Freire-Valls A*, Yerbes R*, Paredes I, La Porta S, Wang X, Martín-Pérez R, Castro L, Wong WW, Coultas L, Strilic B, Gröne HJ, Hielscher T, Mogler C, Adams RH, Heiduschka P, Claesson Welsh L, Mazzone M, López-Rivas A, Schmidt T, Augustin HG, Ruiz de Almodovar C: Caspase-8 modulates physiological and pathological angiogenesis during retina development. J Clin Invest, 129:5092-107, 2019. (*equal contribution)


Karakatsani A, Shah B, Ruiz de Almodovar C: Blood vessels as regulators of neural stem cell properties. Front Mol Neurosci, 12:85, 2019.


Paredes I, Himmels P, Ruiz de Almodovar C: Neuro-vascular communication in the CNS during development. Dev Cell, 45:10-32, 2018.


Wang X, Freire Valls A, Shermann G, Shen X, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodovar C: YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell, 42:462-78.e7, 2017.


Himmels P, Paredes I, Karakatsani A, Luck R, Marti H, Rempel E, Stoeckli E, Ruiz de Almodovar C: Motoneurons guide blood vessels in the developing spinal cord via a sFlt1 dependent mechanism. Nat Commun, 8:14583, 2017.

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