Director, Max Planck Institute for Molecular Biomedicine, Münster

 

Department Tissue Morphogenesis


ralf.adams(at)mpi-muenster.mpg.de

Ralf Adams is Head of the Department of Tissue Morphogenesis at the Max Planck Institute for Molecular Biomedicine in Münster. He obtained his PhD with Heinrich Betz at Frankfurt University. He then moved on to Rüdiger Klein’s laboratory at the EMBL at Heidelberg studying ephrins, before setting up his own group at the Cancer UK London Research Institute. He is now Director of the Max Planck Institute for Molecular Biomedicine in Münster.

Qualifications and Scientific Curriculum

PhD: Biochemistry, Johann Wolfgang Goethe University, Frankfurt


Postdoctoral Research Fellow, EMBL Heidelberg

 

Head of the Vascular Development Laboratory and tenured Senior Group Leader, Cancer UK London Research Institute, London, UK
 

Director, Max Planck Institute for Molecular Biomedicine, Münster

1996

1996-2000 

2000-2008 

since 2007

Selected publications

  1. Sivaraj KK, Dharmalingam B, Mohanakrishnan V, Jeong HW, Kato K, Schröder S, Adams S, Koh GY, Adams RH: YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. Elife, 9:e50770, 2020.

  2. Kato K, Diéguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH: Pulmonary pericytes regulate lung morphogenesis. Nat Commun, 9:2448, 2018.

  3. Park H, Yamamoto H, Mohn L, Ambühl L, Kanai K, Schmidt I, Kim KP, Fraccaroli A, Feil S, Junge HJ, Montanez E, Berger W, Adams RH: Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat Commun, 10:5243, 2019.

  4. Pitulescu ME, Schmidt I, Giaimo BD, Antoine T, Berkenfeld F, Ferrante F, Park H, Ehling M, Biljes D, Rocha SF, Langen UH, Stehling M, Nagasawa T, Ferrara N, Borggrefe T, Adams RH: Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol, 19:915-27, 2017.

  5. Kusumbe AP, Ramasamy SK, Itkin T, Mäe MA, Langen UH, Betsholtz C, Lapidot T, Adams RH: Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature, 532:380-4, 2016.

  6. Ramasamy SK, Kusumbe AP, Wang L, Adams RH: Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature, 507:376-80, 2014.

  7. Kusumbe AP, Ramasamy SK, Adams RH: Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature, 507:323-8, 2014.

  8. Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HC, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH: Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol, 15:249-60, 2013.

  9. Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams RH: Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature, 484:110-4, 2012.

  10. Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH: Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature, 465:483-6, 2010.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University

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D-68167 Mannheim

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