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CRC1366

Vascular Control of Organ Function

Prof. Dr. Michael Platten

Neurological Clinic, University Medical Center Mannheim

and European Center for Angioscience, Medical Faculty Mannheim,

Heidelberg University and German Cancer Research Center (DKFZ) Heidelberg

michael.platten(at)umm.de

Professional Career

Since 2016

Full Professor (W3)

Neurology, University of Heidelberg and Chairman, Department of
Neurology, University Hospital Mannheim, Germany

2010 - 2016

Associate Professor (W3)

Experimental Neuroimmunology

University of Heidelberg, Germany

2007 - 2013

Helmholtz Young Investigator

German Cancer Research Center (DKFZ), Heidelberg, Germany

2002 - 2004

Postdoctoral Fellow

Emmy Noether Fellow, Stanford University, USA

1991 - 1999

Medical School

Universities of Bonn and London, Harvard University

Selected Publications

Friedrich M*, Sankowski R*, Bunse L*, Kilian M, Green E, Ramallo-Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Sonner JK, von Landenberg A, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland DH, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana F, von Deimling A, Wick W, Prinz M*, Platten M*: Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Nat Cancer, 2:723–40, 2021. (*equal contribution)

Platten M, Bunse l, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens G, Breckwoldt M, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W: A vaccine targeting mutant IDH1 in newly diagnosed glioma. Nature, 592:463-8, 2021.

Aslan K, Turco V, Blobner J, Sonner JK, Liuzzi AR, Núñez NG, De Feo D, Kickingereder P, Fischer M, Green E, Sadik A, Friedrich M, Sanghvi K, Kilian M, Cichon F, Wolf L, Jähne K, von Landenberg A, Bunse L, Sahm F, Schrimpf D, Meyer J, Alexander A, Brugnara G, Röth R, Pfleiderer K, Niesler B, von Deimling A, Opitz CA, Breckwoldt MO, Heiland S, Bendszus M, Wick W, Becher B, Platten M:
Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas. Nat Commun, 11:931, 2020.

Sonner JK*, Keil M*, Falk-Paulsen M*, Mishra N, Rehman A, Kramer M, Deumelandt K, Röwe J, Sanghvi K, Wolf L, von Landenberg A, Wolff H, Bharti R, Oezen I, Lanz TV, Wanke F, Tang Y, Brandao I, Mohapatra S, Epping L, Grill A, Röth R, Niesler B, Meuth SG, Opitz CA, Okun JG, Reinhardt C, Kurschus F, Wick W, Bode HB, Rosenstiel P*, Platten M*: Dietary tryptophan links encephalito-genicity of autoreactive T cells with gut microbial ecology. Nat Commun, 10:4877, 2019. (*equal contribution)

Bunse L*, Pusch S*, Bunse T*, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger M, Harter P, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende CM, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hänggi D, Dorsch M, Suva M, Niemeyer BA, von Deimling A, Wick W, Platten M: Suppression of antitumor T cell immunity by the oncometabolite R-2-hydroxyglutarate. Nat Med, 24:1192-203, 2018. (*equal contribution)

Schumacher T*, Bunse L*, Pusch S, Sahm F, Wiestler B, Quandt J, Menn O, Osswald M, Oezen I, Ott M, Keil M, Balss J, Rauschenbach K, Grabowska AK, Vogler I, Diekmann J, Trautwein N, Eichmüller S, Okun J, Stefanovic S, Riemer AB, Sahin U, Friese M, Beckhove P, von Deimling A, Wick W, Platten M: A vaccine targeting mutant IDH1 induces antitumor immunity. Nature, 512:324-7, 2014. (*equal contribution)

Opitz CA*, Litzenburger UM*, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M: An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature, 478:197-203, 2011. (*equal contribution)

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