CRC1366
Vascular Control of Organ Function
Prof. Dr. Lothar Dieterich
(Associated Member) Project AP
European Center for Angioscience (ECAS)
Medical Faculty Mannheim, Heidelberg University
Professional Career
Since 2023
Heisenberg Professor
Anatomy and Developmental Biology with Focus on the Cardiovascular System, European Center for Angioscience (ECAS)
Medical Faculty Mannheim, Heidelberg University, Germany
2022 - 2023
Senior Scientist
European Center for Angioscience (ECAS)
Medical Faculty Mannheim, Heidelberg University
2018 - 2022
Senior Scientist
Institute of Pharmaceutical Sciences
ETH Zurich, Switzerland
2012 - 2018
Post-doctoral Fellow
Institute of Pharmaceutical Sciences, ETH Zurich
2011 - 2012
Post-doctoral Fellow
Department of Immunology, Genetics and Pathology
Uppsala University, Sweden
2007 - 2011
Ph.D.
in Molecular Medicine, Department of Immunology,
Genetics and Pathology, Uppsala University
Selected Publications
(§ indicates equal contribution)
Dieterich LC§, Tacconi C§, Ducoli L, Detmar M. The lymphatic vessels in cancer. Physiol Rev. 2022 Oct 1;102(4):1837-1879.
Sibler E§, He Y§, Ducoli L, Rihs V, Sidler P, Puig-Moreno C, Frey J, Fujimoto N, Detmar M, Dieterich LC. Immunomodulatory responses of subcapsular sinus floor lymphatic endothelial cells in tumor-draining lymph nodes. Cancers. 2022 Jul 24; 14(15):3602.
Leary N, Walser S, He Y, Pereira P, Gallo A, Collado-Diaz V, Halin C, Peinado H, Dieterich LC. Melanoma-derived extracellular vesicles mediate lymphatic remodeling and impair tumor immunity in draining lymph nodes. J Extracell Vesicles. 2022 Feb; 11(2):e12197.
Cousin N§, Cap S§, Dihr M§, Tacconi C, Detmar M, Dieterich LC. Lymphatic PD-L1 expression restricts tumor-specific CD8+ T cell responses. Cancer Res. 2021 Aug 1; 81(15):4133-4144.
Sibler E§, He Y§, Ducoli L, Keller N, Fujimoto N, Dieterich LC, Detmar M. Single-cell transcriptional heterogeneity of lymphatic endothelial cells in normal and inflamed murine lymph nodes. Cells. 2021 Jun 2; 10(6):1371.
Dieterich LC§, Tacconi C§, Menzi F, Proulx ST, Kapaklikaya K, Hamada M, Takahashi S, Detmar M. Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis. Angiogenesis. 2020 Aug; 23(3):411-423.
Fujimoto N§, He Y§, D’Addio M, Tacconi C, Detmar M, Dieterich LC. Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes. PLoS Biol. 2020 Apr 6;18(4):e3000704.
Commerford CD§, , He Y, Hell T, Montoya-Zegarra JA, Noerrelykke SF, Russo E, Röcken M, Detmar M, Dieterich LC. Mechanisms of tumor-induced lymphovascular niche formation in draining lymph nodes. Cell Rep. 2018 Dec 26;25(13):3554-3563.e4.
Dieterich LC, Ikenberg K, Cetintas T, Kapaklikaya K, Hutmacher C, Detmar M. Tumor-associated lymphatic vessels upregulate PDL1 to inhibit T-cell activation. Front Immunol. 2017 Feb 3;8:66.
Dieterich LC§, Klein S§, Mathelier A, Sliwa-Primorac A, Ma Q, Hong YK, Shin JW, Hamada M, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E, Carninci P, Hayashizaki Y, Forrest ARR, Wasserman WW, Detmar M. DeepCAGE transcriptomics reveal an important role of the transcription factor MAFB in the lymphatic endothelium. Cell Rep. 2015 Nov 17;13(7):1493-504.