CRC1366
Vascular Control of Organ Function
Professional Career
Since 2018
Speaker
German Center for Cardiovasular Research (DZHK)
Berlin (Partner Site)
Since 2014
Head
of the Integrative Vascular Biology Laboratory, Max-Delbrück Center
for Moilecular Medicine, Berlin-Buch, Germany
Since 2010
Independent Consultant Group Leader
Vascular Patterning Laboratory, CCB, VIB KU Leuven, Belgium
2009 - 2014
Head of Laboratory, Senior Group Leader
Vascular Biology, Cancer Research Institute, London, UK
2004 - 2009
Head of Laboratory
Vascular Biology, Cancer Research Institute, London, UK
2000 - 2004
Post-doctoral Fellow
Department of Medical Biochemistry, University of Gøteborg, Sweden
2000
Ph.D.
in Cell Biology, University of Tübingen, Germany
Selected Publications
Zhao X, Nedvetsky P, Stanchi F, Vion AC, Popp O, Zühlke K, Dittmar G, Klussmann E, Gerhardt H: Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1. Elife, 8:e46380, 2019.
Geudens I, Coxam B, Alt S, Gebala V, Vion AC, Meier K, Rosa A, Gerhardt H: Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine-tuning. Development, 146:dev181024, 2019.
Vion AC, Alt S, Klaus-Bergmann A, Szymborska A, ÄZheng T, Perovic T, Hammoutene A, Oliveira MB, Bartels-Klein E, Hollfinger I, Rautou PE, Bernabeu MO, Gerhardt H: Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression. J Cell Biol, 217:1651-65, 2018.
Neto F, Klaus-Bergmann A, Ong YT, Alt S, Vion AC, Szymborska A, Carvalho JR, Hollfinger I, Bartels-Klein E, Franco CA, Potente M, Gerhardt H: YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development. Elife, 7.pii:e31037, 2018.
Gebala V, Collins R, Geudens I, Phng LK, Gerhardt H: Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo. Nat Cell Biol, 18:443-50, 2016.
Phng LK, Gebala V, Bentley K, Philippides A, Wacker A, Mathivet T, Sauteur L, Stanchi F, Belting HG, Affolter M, Gerhardt H: Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization. Dev Cell, 32:123-32, 2015.
Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, Westrom S, Claesson-Welsh L, Vestweber D, Gerhardt H: The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol, 16:309-21, 2014.
Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM, Rosewell I, Busse M, Thurston G, Medvinsky A, Schulte-Merker S, Gerhardt H: Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol, 12:943-53, 2010.
Phng LK, Potente M, Leslie JD, Babbage J, Nyqvist D, Lobov I, Ondr JK, Rao S, Lang RA, Thurston G, Gerhardt H: Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell, 16:70-82, 2009.
Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H*, Vanhaesebroeck B*: Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature, 453:662-6, 2008 (*corresponding author).