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CRC1366

Vascular Control of Organ Function

Prof. Dr. Adelheid Cerwenka

Department of Immunobiochemistry

Institute for Innate Immunoscience (MI3),

European Center for Angioscience (ECAS),

Medical Faculty Mannheim, Heidelberg University

adelheid.cerwenka(at)medma.uni-heidelberg.de

Professional Career

Since 2017

Professor

of Immunobiochemistry (W3)

Director, Mannheim Institute for Innate Immunoscience (MI3)

Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

2003 - 2016

Head

Boveri Junior Research Group 'Innate Immunity',

German Cancer Research Center, Heidelberg, Germany

2001 - 2003

Head of Laboratory

Division of Autoimmune Diseases, Novartis Research Institute,

Vienna, Austria

1998 - 2001

Postdoctoral Fellow

DNAX Research Institute and University of California,

San Francisco, USA

1996 - 1998

Postdoctoral Fellow

University of California, San Diego, Calif., USA and

Trudeau Institute, New York, USA

1991 - 1995

Ph.D.

Institute of Immunology, University of Vienna, Austria

Selected Publications

Stojanovic A, Cerwenka A: An intimate encounter: DC3s empower anti-tumor CTLs. Cancer Cell. 39:1181-3, 2021.

Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A: Single-cell RNA sequencing of tumor-infiltrating NK cells reveals that inhibition of transcription factor HIF-1α unleashes NK cell activity. Immunity. 52:1075-87.e8, 2020.

Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar Š, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M: Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells. Nat Immunol. 21:766-76, 2020.

Correia MP, Stojanovic A, Bauer K, Juraeva D, Tykocinski LO, Lorenz HM, Brors B, Cerwenka A: Distinct human circulating NKp30+FcεRIγ+CD8+ T cell population exhibiting high natural killer-like antitumor potential. Proc Natl Acad Sci USA. 115:E5980-9, 2018.

Pahl JHW, Koch J, Gotz JJ, Arnold A, Reusch U, Gantke T, Rajkovic E, Treder MS, Cerwenka A: CD16A activation of NK cells promotes NK cell proliferation and memory-like cytotoxicity against cancer cells. Cancer Immunol Res. 6:517-27, 2018.

Pollmann J, Götz JJ, Rupp D, Strauss O, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A: Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis. J Hepatol. 68:421-30, 2018.

Cerwenka A, Lanier LL: Natural killer cell memory in infection, inflammation and cancer. Nat Rev Immunol. 16:112-23, 2016.

Rölle A, Pollmann J, Ewen E, Halenius A, Hengel H, Cerwenka A: IL-12 producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion. J Clin Invest. 124:5305-16, 2014.

Ni J, Miller M, Stojanovic A, Garbi N, Cerwenka A: Sustained effector function of IL-12/15/18 preactivated NK cells against established tumors. J Exp Med. 209:2351-65, 2012.

Cerwenka A, Bakker ABH, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL: Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity. 12:721-7, 2000.

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