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Prof. Dr. Thomas Korff

Project B5

Medical Faculty Heidelberg and

European Center for Angioscience,

Medical Faculty Mannheim, Heidelberg University

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korff(at)physiologie.uni-heidelberg.de

Thomas Korff pursued his graduate studies at the Cell Biology Laboratory at the Department of Obstetrics and Gynecology at the University of Göttingen. He stayed there as a postdoctoral fellow before starting his own group as a junior group leader at the Department of Vascular Biology and Angiogenesis Research at the Tumor Biology Center in Freiburg. He then went back as a research associate followed by a junior professorship to Göttingen. In Heidelberg he got head of the Blood vessel remodeling group at the Institute of Physiology and Pathophysiology at Heidelberg University. Since 2013 he is adjunct professor at Heidelberg University.

Qualifications and Scientific Curriculum

1991-1996

1996-1999

2000-2001

2001-2003

2003

2003-2005

since 2005

2013

Diploma, Human Biology, Phillips University Marburg, Germany

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Graduate Student, Cell Biology Laboratory, Department of Obstetrics and Gynecology, University of Göttingen, Germany

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Postdoctoral Associate, Cell Biology Laboratory, Department of Obstetrics and Gynecology, University of Göttingen, Germany

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Junior Group Leader, Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, Germany

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Research Associate, Department of Cardiovascular Physiology, University of Göttingen, Germany

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Juniorprofessorship, Department of Cardiovascular Physiology, University of Göttingen, Germany

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Group head “Blood vessel remodeling”, Institute of Physiology and Pathophysiology, Heidelberg University, Germany

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Adjunct professorship

Selected publications​

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  1. Jäger MA, De La Torre C, Arnold C, Kohlhaas J, Kappert L, Hecker M, Feldner A, Korff T: Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res, 388:111782, 2020.

  2. Arnold C, Feldner A, Zappe M, Komljenovic D, De La Torre C, Ruzicka P, Hecker M, Neuhofer W, Korff T: Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J, 33:3364-3377, 2019.

  3. Zappe M, Feldner A, Arnold C, Sticht C, Hecker M, Korff T: NFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells. Front Physiol, 9:1190, 2018.

  4. Kuk H, Arnold C, Wagner AH, Hecker M, Sticht C, Korff T: Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice. Front Physiol, 9:320, 2018.

  5. Arnold C, Demirel E, Feldner A, Genové G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T: Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J, 32:2021-35, 2018.

  6. Eschrich J, Meyer R, Kuk H, Wagner AH, Noppeney T, Debus S, Hecker M, Korff T: Varicose remodeling of veins is suppressed by 3-hydroxy-3-methylglutaryl coenzyme A reductase Inhibitors. J Am Heart Assoc, 5:e002405, 2016.

  7. Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T: Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc, 3:e000626, 2014.

  8. Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T: RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med, 6:993-1104, 2014.

  9. Demicheva E, Hecker M, Korff T: Stretch-induced activation of the transcription factor activator protein-1 controls monocyte chemoattractant protein-1 expression during arteriogenesis. Circ Res, 103:477-84, 2008.

  10. Korff T, Braun J, Pfaff D, Augustin H and Hecker M: Role of ephrinB2 in endothelial cells during arteriogenesis: Impact on smooth muscle cell migration and monocyte recruitment. Blood, 112:73-81, 2008.

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