CRC1366
Vascular Control of Organ Function
Contact
Spokesperson
Prof. Dr. Hellmut G. Augustin
European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University and DKFZ, Heidelberg
Vice Spokesperson
Prof. Dr. Sergij Goerdt
University Hospital for Dermatology,
Venereology and Allergology and European Center for Angioscience (ECAS) University Medical Centre Mannheim, Heidelberg University
Origin of EC during tissue regeneration
Singhal M, Liu X, Inverso D, Jiang K, Dai J, He H, Bartels S, Li W, Abdul Pari AA, Gengenbacher N, Besemfelder E, Hui L, Augustin HG, Hu J: Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med. 2018 Oct 1;215(10):2497-2508.
Construction management in blood vessels
Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Elife. 2018; 7. pii: e34423. doi: 10.7554/eLife.34423.
Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis
La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, Augustin HG. Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest. 128:834-45, 2018
Pericyte-expressed Tie2 controls angiogenesis and maturation
Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG: Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun. 8:16106, 2017
European Research Council Grant for Hellmut Augustin
Recently, Prof. Dr. Hellmut Augustin (DKFZ and Heidelberg University) received a European Research Council Advanced Grant for his Proposal: AngioMature “Mechanisms of vascular maturation and quiescence during development, homeostasis and ageing”. The goal of the AngioMature project is the detailed and mechanistic analysis of vascular maturation and organotypic differentiation programs and the functional consequences of such programs for tissue homeostasis in the adult and adaptation to pathologic challenge as well as changes during aging.
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