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Prof. Dr. Stefanie Dimmeler

Project B4

Institute of Cardiovascular Regeneration

Goethe University, Frankfurt

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dimmeler(at)em.uni-frankfurt.de

Stefanie Dimmeler is Director of the Institute of Cardiovascular Regeneration at Frankfurt University. She pursued her undergraduate training at the University of Konstanz. She then moved to do postdoctoral training at the Department of Experimental Surgery at the University of Cologne and the Department of Molecular Cardiology the University of Frankfurt, before she started her own group as Head of the Department of Molecular Cardiology at Frankfurt University.

Qualifications and Scientific Curriculum

Biology, University of Konstanz, Germany, Diploma

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Biological Chemistry, Department of Biological Chemistry, University of Konstanz, Germany

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Postdoctoral Fellow, Dept. of Experimental Surgery, University of Cologne, Germany

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Postdoctoral Fellow, Dept. of Molecular Cardiology, University of Frankfurt, Germany

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Associated Professor, Head of Dept. of Molecular Cardiology, University of Frankfurt, Germany

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Full Professorship, Head of Dept. Molecular Cardiology, University of Frankfurt, Germany

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Full Professorship, Director of the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, University of Frankfurt, Germany

1987-1991

1991-1993

1992-1995

1995-1997

1998-2000

2000-2008

since 2008

Selected publications

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  1. Nicin L, Schroeter SM, Glaser S, Schulze-Brüning R, Pham M-D, Hille SS, Yekelchyk M, Badder K, Abplanalp WT, Tombor L, Müller OJ, Baun T, Meder B, Reich C, Arsalan M, Holubec T, Walther T, Emrich F, Krishnan J, Zeiher AM, John D, Dimmeler S: A human cell atlas of the pressure-induced hypertrophic heart. Nat Cardiovasc Res. 1:174-185, 2022.

  2. Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S: Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun. 12:681, 2021.

  3. Hoffmann J, Luxán G, Abplanalp WT, Glaser SF, Rasper T, Fischer A, Muhly-Reinholz M, Potente M, Assmus B, John D, Zeiher AM, Dimmeler S: Post-myocardial infarction heart failure dysregulates the bone vascular niche. Nat Commun. 12:3964, 2021.

  4. Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J: Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Sci Transl Med. 13:eabi7964, 2021.

  5. Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. Proc Natl Acad Sci U S A. 117: 4180-4187, 2020.

  6. Neumann P, Jaé N, Knau A, Glaser SF, Fouani Y, Rossbach O, Krüger M, John D, Bindereif A, Grote P, Boon RA, Dimmeler S: The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2. Nat Commun. 9:237, 2018.

  7. Manavski Y, Lucas T, Glaser SF, Dorsheimer L, Günther S, Braun T, Rieger MA, Zeiher AM, Boon RA, Dimmeler S: Clonal expansion of endothelial cells contributes to ischemia-induced neovascularization. Circ Res, 122:670-7, 2018.

  8. Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S: Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med, 22:1140-50, 2016.

  9. Boon RA, Iekushi K, Lechner S, Fischer A, Heydt S, Kaluza D, Treguer K, Carmona G, Bonauer A, Horrevoets AJ, Girmatsion Z, Biliczki P, Ehrlich JR, Potente M, Zeiher AM, Hermeking H, Dimmeler S: miRNA-34a regulates cardiac ageing and function. Nature, 495:107-10, 2013.

  10. Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S: Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol, 14:249-56, 2012.

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