Institute of Cardiovascular Regeneration

Goethe University, Frankfurt

dimmeler(at)em.uni-frankfurt.de

Stefanie Dimmeler is Director of the Institute of Cardiovascular Regeneration at Frankfurt University. She pursued her undergraduate training at the University of Konstanz. She then moved to do postdoctoral training at the Department of Experimental Surgery at the University of Cologne and the Department of Molecular Cardiology the University of Frankfurt, before she started her own group as Head of the Department of Molecular Cardiology at Frankfurt University.

Qualifications and Scientific Curriculum

Biology, University of Konstanz, Germany, Diploma

Biological Chemistry, Department of Biological Chemistry, University of Konstanz, Germany

Postdoctoral Fellow, Dept. of Experimental Surgery, University of Cologne, Germany

Postdoctoral Fellow, Dept. of Molecular Cardiology, University of Frankfurt, Germany

Associated Professor, Head of Dept. of Molecular Cardiology, University of Frankfurt, Germany

Full Professorship, Head of Dept. Molecular Cardiology, University of Frankfurt, Germany

Full Professorship, Director of the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, University of Frankfurt, Germany

1987-1991

1991-1993

1992-1995

1995-1997

1998-2000

2000-2008

since 2008

Selected publications

  1. Manavski Y, Lucas T, Glaser SF, Dorsheimer L, Günther S, Braun T, Rieger MA, Zeiher AM, Boon RA, Dimmeler S: Clonal expansion of endothelial cells contributes to ischemia-induced neovascularization. Circ Res, 122:670-7, 2018.

  2. Manavski Y, Abel T, Hu J, Kleinlützum D, Buchholz CJ, Belz C, Augustin HG, Boon RA, Dimmeler S: Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A.  Proc Natl Acad Sci U S A, 114:3993-8, 2017.

  3. Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S: Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med, 22:1140-50, 2016.

  4. Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S: Identification and characterization of hypoxia-regulated endothelial circular RNA.Circ Res, 117:884-90, 2015.

  5. Boon RA, Iekushi K, Lechner S, Fischer A, Heydt S, Kaluza D, Treguer K, Carmona G, Bonauer A, Horrevoets AJ, Girmatsion Z, Biliczki P, Ehrlich JR, Potente M, Zeiher AM, Hermeking H, Dimmeler S: miRNA-34a controls cardiac aging and function. Nature, 495:107-10, 2013.

  6. Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S: Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol, 14:249-56, 2012.

  7. Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M: Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature, 473:234-8, 2011.

  8. Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M. Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher AM, Dimmeler S: MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science, 324:1710-3, 2009.

  9. Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S: Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med, 11:206-13, 2005.

  10. Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, Zeiher AM, Dimmeler S: Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med, 9:1370-6, 2003.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450