Prof. Dr. Sofia Iris Bibli

Institute of Vascular Signaling

Centre for Molecular Medicine

Goethe University, Frankfurt



Sofia Iris Bibli is a Postdoctoral Fellow in the laboratory of Ingrid Fleming at the Institute for Vascular Signalling at Frankfurt University. She graduated in Molecular Pharmacology at the National and Kapodestrian University of Athens, before pursuing her postdoctoral training in Andreas Papapetropouloś s laboratory at the Biomedical Research Foundation Academy of Athens, studying the role of hydrogen sulfide in the cardiovascular system.

Qualifications and Scientific Curriculum

Molecular Pharmacology, University of Patras,

Master of Science

PhD, Molecular Pharmacology, National and Kapodestrian University of Athens, Greece 

Postdoctoral Fellow, Bioacademy Research Foundation Athens, Greece

Postdoctoral Fellow, Institute for Vascular Signalling, Goethe University, Frankfurt/Main, Germany




since 2016

Selected publications

  1. Bibli SI, Hu J, Leisegang MS, Wittig J, Zukunft S, Kapasakalidi A, Fisslthaler B, Tsilimigras D, Zografos G, Filis K, Brandes RP, Papapetropoulos A, Sigala F, Fleming I: Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation. Redox Biol, 28:101379, 2020.

  2. Hu J, Bibli SI, Wittig J, Zukunft S, Lin J, Hammes HP, Popp R, Fleming I: Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity. J Clin Invest, 129:5204-5218, 2019.

  3. Bibli SI, Papapetropoulos A, Iliodromitis EK, Daiber A, Randriamboavonjy V, Steven S, Brouckaert P, Chatzianastasiou A, Kypreos KE, Hausenloy DJ, Fleming I, Andreadou I: Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug. Cardiovasc Res, 15:625-636, 2019.

  4. Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Randriamboavonjy V, Wittig J, Siuda D, Kojonazarov B, Tsilimigras D, Schürmann C, Siragusa M, Luck B, Abdel Malik R, Filis K A, Zografos G, Chen C, Wang D W, Pfeilschifter J, Brandes R P, Szabo C, Papapetropoulos A, Fleming I: Cystathionine gamma-lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherogenesis. Circulation, 139:101-114, 2019.

  5. Köhler D, Bibli SI, Klammer LP, Roth JM, Lehmann R, Fleming I, Granja1 TF, Straub A, Benz PM, Rosenberger P: Vasodilator-Stimulated Phosphoprotein phosphorylation is crucial for myocardial ischemic preconditioning. Bas Res Cardiol, 113:11, 2018.

  6. Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S,de Mos J, Awwad K, Froemel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A,  Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes H-P, Popp R, Fleming I: Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature, 552:248-52, 2017.

  7. Bibli SI, Szabo C, Chatzianastasiou A, Zukunft S, Fleming I, Papapetropoulos A: Hydrogen sulfide preserves eNOS function by inhibiting PYK2: implications for cardiomyocyte survival and cardioprotection. Mol Pharmacol, 92:718-30, 2017.

  8. Bibli SI, Zhou Z, Zukunft S, Fissthaler B, Brouckaert P, Andreadou I, Fleming I, Papapetropoulos A: Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischemic insult: role of PYK2. Cardiovasc Res, 113:926-37, 2017.

  9. Bibli SI, Andreadou I, Glynos C, Chatzianastasiou A, Toumpanakis D, Zakynthinos S, Vasilakopoulos T, Iliodromitis EK, Papapetropoulos A: Exposure to cigarette smoke abrogates the beneficial effect of ischemic postconditioning. Am J Physiol Heart Circ Physiol, 311:H1321-32, 2016.

  10. Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis EK, Papapetropoulos A: Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway. Cardiovasc Res, 106:432-42, 2015.