Dr. Sofia Iris Bibli

Institute of Vascular Signaling

Centre for Molecular Medicine

Goethe University, Frankfurt



Sofia Iris Bibli is a Postdoctoral Fellow in the laboratory of Ingrid Fleming at the Institute for Vascular Signalling at Frankfurt University. She graduated in Molecular Pharmacology at the National and Kapodestrian University of Athens, before pursuing her postdoctoral training in Andreas Papapetropouloś s laboratory at the Biomedical Research Foundation Academy of Athens, studying the role of hydrogen sulfide in the cardiovascular system.

Qualifications and Scientific Curriculum

Molecular Pharmacology, University of Patras,

Master of Science

PhD, Molecular Pharmacology, National and Kapodestrian University of Athens, Greece 

Postdoctoral Fellow, Bioacademy Research Foundation Athens, Greece

Postdoctoral Fellow, Institute for Vascular Signalling, Goethe University, Frankfurt/Main, Germany




since 2016

Selected publications

  1. Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Randriamboavonjy V, Wittig J, Siuda D, Kojonazarov B, Tsilimigras D, Schürmann C, Siragusa M, Luck B, Abdel Malik R, Filis K A, Zografos G, Chen C, Wang D W, Pfeilschifter J, Brandes R P, Szabo C, Papapetropoulos A, Fleming I: Cystathionine gamma-lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherogenesis. Circulation, in press, 2018.

  2. Köhler D, Bibli SI, Klammer LP, Roth JM, Lehmann R, Fleming I, Granja1 TF, Straub A, Benz PM, Rosenberger P: Vasodilator-Stimulated Phosphoprotein phosphorylation is crucial for myocardial ischemic preconditioning. Bas Res Cardiol, 113:11, 2018.

  3. Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S,de Mos J, Awwad K, Froemel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A,  Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes H-P, Popp R, Fleming I: Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature, 552:248-52, 2017.

  4. Bibli SI, Szabo C, Chatzianastasiou A, Zukunft S, Fleming I, Papapetropoulos A: Hydrogen sulfide preserves eNOS function by inhibiting PYK2: implications for cardiomyocyte survival and cardioprotection. Mol Pharmacol, 92:718-30, 2017.

  5. Bibli SI, Zhou Z, Zukunft S, Fissthaler B, Brouckaert P, Andreadou I, Fleming I, Papapetropoulos A: Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischemic insult: role of PYK2. Cardiovasc Res, 113:926-37, 2017.

  6. Bibli SI, Andreadou I, Glynos C, Chatzianastasiou A, Toumpanakis D, Zakynthinos S, Vasilakopoulos T, Iliodromitis EK, Papapetropoulos A: Exposure to cigarette smoke abrogates the beneficial effect of ischemic postconditioning. Am J Physiol Heart Circ Physiol, 311:H1321-32, 2016.

  7. Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis EK, Papapetropoulos A: Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway. Cardiovasc Res, 106:432-42, 2015.

  8. Andreadou I, Bibli SI, Mastromanolis E, Zoga A, Efentakis P, Farmakis D, Kremastinos DTh, Iliodromitis EK: Transient carotid ischemia as a remote conditioning stimulus for myocardial protection in anesthetized rabbits: Insights into intracellular signaling. Int J Cardiol, 184C:140-51, 2015.

  9. Bibli SI, Iliodromitis EK, Lambertucci C, Zoga A, Lougiakis N, Dagres N, Volpini R, Dal Ben D, Kremastinos DTh, Tsantili Kakoulidou A, Cristalli G, Andreadou I: Pharmacological postconditioning of the rabbit heart with non-selective, A1, A2A and A3 adenosine receptor agonists. J Pharm Pharmacol, 66:1140-9, 2014.

  10. Bibli SI, Andreadou I, Lazaris E, Zoga A, Varnavas V, Andreou CC, Dagres N, Iliodromitis EK, Kyriakides ZS: Myocardial protection provided by chronic skeletal muscle ischemia is not further enchanced by ischemic pre- or postconditioning: Comparative effects on intracellular signaling. J Cardiovasc Ther, 19:220-7, 2014.


European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University

Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450