Chairman, Dept. of Dermatology, Venereology, and Allergology,

University Medical Center Mannheim, Heidelberg University

sergij.goerdt(at)umm.de

Sergij Goerdt is Chairman of the Department of Dermatology, Venereology and Allergology at the University Medical Center Mannheim at Heidelberg University. He attended the Medical Collage at the Universities of Münster, Mainz, Wien and Freiburg. As a research assistant he worked at the Institute of Experimental Dermatology at the University of Münster. He then moved on to Havard Medical School in Bosten, before becoming Vice Chairman at the Department of Dermatology at the University Hospital Benjamin Franklin, Freie Universität Berlin. Now he is Dean of the Medical Faculty Mannheim at Heidelberg University.

Qualifications and Scientific Curriculum

Medical College, Universities of Münster, Mainz, Wien, and Freiburg

Research Assistant, Inst. Exp. Dermatology, University of Münster

Resident, Deptartment of Dermatology,
University of Münster

Visiting Research Fellow, Harvard Medical School, Boston, MA

Vice Chairman, Dept. Dermatology, UKBF, FU Berlin

Associate Professor for Dermatology and Venereology, FU Berlin

President, Dermatological Society of Berlin

Chairman, Dept. Dermatology, University Medical Center Mannheim, Heidelberg University

Vice Dean for Structure and Development, Med. Faculty Mannheim

Vice Dean, Medical Faculty Mannheim, Heidelberg University

Dean, Medical Faculty Mannheim, Heidelberg University

Founding Director, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University

1978-1985

1985-1987

1989-1991

1995-2000

1987/89
1991/94

1997

1997-1999

since 2000

2006-2010

2013-2015

since 2015

since 2017

Selected publications

  1. Wohlfeil SA, Häfele V, Dietsch B, Schledzewski K, Winkler M, Zierow J, LeibingT, Mohammadi MM, Heineke J, Sticht C, Olsavszky V, Koch PS, Géraud C, Goerdt S. Hepatic endothelial notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res. 79:598-610, 2019. 

  2. Manta C, Meyer M, Géraud C, Roscher M, Goerdt S, Schoenberg SO, Henzler T, Ong MM: Detection of calcified aortic plaques in an apolipoprotein E animal model using a human computed tomography system for ultra-high-resolution Imaging: A feasibility study. J Thorac Imaging, 34:41-7, 2019. 

  3. Nahon JE, Hoekstra M, van Hulst S, Manta C, Goerdt S, Geerling JJ, Géraud C, Van Eck M: Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice. Atherosclerosis, 281:47-55, 2018. 

  4. Swystun LL, Lai JD, Notley C, Georgescu I, Paine AS, Mewburn J, Nesbitt K, Schledzewski K, Géraud C, Kzhyshkowska J, Goerdt S, Hopman W, Montgomery RR, James PD, Lillicrap D. The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity. J Clin Invest. 128:4057-73, 2018. 

  5. Leibing T, Géraud C, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology, 68:707-22, 2018. 

  6. Leibing T, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S*, Koch PS: Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice, Hepatology, doi:10.1002, 2017 (*corresponding author).

  7. Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest, 127:1099-114, 2017 (*equal contribution).

  8. Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood, 29:415-9, 2017 (*equal contribution).

  9. Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA: Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity, 41:14-20, 2014.

  10. Schledzewski K*, Géraud C*, Arnold B, Wang S, Gröne HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schönhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S: Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest, 121:703-14, 2011  (*equal contribution).

  11. Géraud C*, Schledzewski K*, Demory A, Klein D, Kaus M, Peyre F, Sticht C, Evdokimov K, Lu S, Schmieder A, Goerdt S: Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Hepatology, 52:313-26, 2010.

  12. Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J, Schledzewski K, Arnold B, Goerdt S: Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology, 47:1018-31, 2008.

  13. Kzhyshkowska J, Mamidi S, Gratchev A, Kremmer E, Schmuttermaier C, Krusell L, Haus G, Utikal J, Schledzewski K, Scholtze J, Goerdt S: Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood, 107: 3221-8, 2006.

  14. Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S: Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J, 362:155-64, 2002.

  15. Goerdt S, Walsh LJ, Murphy GF, Pober JS: Identification of a novel high molecular weight protein preferentially expressed by sinusoidal endothelial cells in normal human tissues, J Cell Biol, 113:1425-37, 1991.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450