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Prof. Dr. Sergij Goerdt

Project B2

Chairman, Dept. of Dermatology, Venereology, and Allergology,

University Medical Center Mannheim, Heidelberg University

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sergij.goerdt(at)umm.de

Sergij Goerdt is Chairman of the Department of Dermatology, Venereology and Allergology at the University Medical Center Mannheim at Heidelberg University. He attended the Medical Collage at the Universities of Münster, Mainz, Wien and Freiburg. As a research assistant he worked at the Institute of Experimental Dermatology at the University of Münster. He then moved on to Havard Medical School in Bosten, before becoming Vice Chairman at the Department of Dermatology at the University Hospital Benjamin Franklin, Freie Universität Berlin. Now he is Dean of the Medical Faculty Mannheim at Heidelberg University.

Qualifications and Scientific Curriculum

Medical College, Universities of Münster, Mainz, Wien, and Freiburg

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Research Assistant, Inst. Exp. Dermatology, University of Münster

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Resident, Deptartment of Dermatology,
University of Münster

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Visiting Research Fellow, Harvard Medical School, Boston, MA

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Vice Chairman, Dept. Dermatology, UKBF, FU Berlin

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Associate Professor for Dermatology and Venereology, FU Berlin

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President, Dermatological Society of Berlin

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Chairman, Dept. Dermatology, University Medical Center Mannheim, Heidelberg University

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Vice Dean for Structure and Development, Med. Faculty Mannheim

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Vice Dean, Medical Faculty Mannheim, Heidelberg University

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Dean, Medical Faculty Mannheim, Heidelberg University

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Founding Director, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University

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1978-1985

1985-1987

1989-1991

1995-2000

1987/89
1991/94

1997

1997-1999

since 2000

2006-2010

2013-2015

since 2015

since 2017

Selected publications

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  1. Heil J*, Olsavszky V*, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber J, Zierow J, Winkler M, Schmid CD, Staniczek S, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S*, Koch PS*: Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat. Commun. 12:6963, 2021. (*equal contribution)

  2. Winkler M*, Staniczek T*, Kürschner SW*, Schmid CD*, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C*, Koch PS*, Goerdt S*: Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 74:380-393, 2021. (*equal contribution)

  3. Wohlfeil SA*, Hafele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Mohammadi MM, Heineke J, Sticht C, Olsavszky V, Koch PS, Geraud C*, Goerdt S*: Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res. 79:598-610, 2019. (*equal contribution)

  4. Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest. 127:1099-114, 2017. (*equal contribution)

  5. Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood, 129:415-9, 2017 (*equal contribution).

  6. Schledzewski K*, Géraud C*, Arnold B, Wang S, Gröne HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schönhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S: Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest, 121:703-14, 2011  (*equal contribution).

  7. Géraud C*, Schledzewski K*, Demory A, Klein D, Kaus M, Peyre F, Sticht C, Evdokimov K, Lu S, Schmieder A, Goerdt S: Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Hepatology, 52:313-26, 2010.

  8. Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J, Schledzewski K, Arnold B, Goerdt S: Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology, 47:1018-31, 2008.

  9. Kzhyshkowska J, Mamidi S, Gratchev A, Kremmer E, Schmuttermaier C, Krusell L, Haus G, Utikal J, Schledzewski K, Scholtze J, Goerdt S: Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood, 107: 3221-8, 2006.

  10. Goerdt S, Orfanos CE: Other functions, other genes: alternative activation of antigen-presenting cells. Immunity. 10:137-42, 1999. 

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