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Dr. Sepp Jansen

Project C3

Experimental Pharmacology

European Center for Angioscience (ECAS)

Medical Faculty Mannheim, Heidelberg University

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sepp.jansen(at)medma.uni-heidelberg.de

Sepp Jansen is currently a postdoctoral fellow at the Institute for Experimental and Clinical Pharmacology and Toxicology at the Medical Faculty Mannheim. He studied biology at the University of Groningen and obtained his PhD at the Medical Pharmaceutical Drug Innovation at the University of Groningen under the supervision of Martina Schmidt and Reinoud Gosens.

Qualifications and Scientific Curriculum

Biology, University of Groningen, Netherlands, BSc

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Medical Pharmaceutical Drug Innovation, University of Groningen, MSc

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PhD: “Second messengers in cancer: cyclic AMP meets β-catenin in tumor progression”, University of Groningen

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Postdoctoral fellow, Institute for Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University

2006-2009

2009-2001

2016

since 2016

Selected publications

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  1. Jansen SR, Gosens R, Wieland T, Schmidt M: Paving the Rho in cancer metastasis: Rho GTPases and beyond. Pharmacol Ther, 183:1-21, 2018.

  2. Garg J, Feng YX, Jansen SR, Friedrich J, Lezoualc'h F, Schmidt M, Wieland T: Catecholamines facilitate VEGF-dependent angiogenesis via β2-adrenoceptor-induced Epac1 and PKA activation. Oncotarget, 8:44732-48, 2017.

  3. Jansen SR, Poppinga WJ, de Jager W, Lezoualc'h F, Cheng X, Wieland T, Yarwood SJ, Gosens R, Schmidt M: Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition. Oncotarget, 7:46354-70, 2016.

  4. Spanjer AR, Baarsma HA, Oostenbrin LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M: TGFβ-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. FASEB J, 30:1823-35, 2016.

  5. Jansen SR, Holman R, Hedemann I, Frankes E, Elzinga CR, Timens W, Gosens R, de Bont ES, Schmidt M: Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. J Cell Mol Med, 19:210-26, 2015.

  6. Jansen SR, Van Ziel AM, Baarsma HA, Gosens R: β-Catenin regulates airway smooth muscle contraction. Am J Physiol Lung Cell Mol Physiol, 299:204-14, 2010.

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