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Junior Prof. Dr. Roxana Ola

Associated Member since 07/20 | Project

CardioVascular Pharmacology, Experimental Pharmacology 

European Center for Angioscience (ECAS)
Medical Faculty Mannheim Heidelberg University

 

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roxana.ola(at)medma.uni-heidelberg.de

Roxana Ola is a Junior Professor in the Cardiovascular Pharmacology in the Department of Experimental Pharmacology, Medical Faculty Mannheim, University of Heidelberg. She graduated in Biology and Chemistry in Babes-Bolyai University, Cluj Napoca, Romania, and obtained her PhD in the Faculty of Medicine, Helsinki University. Thereafter she pursued her postdoctoral training at Yale School of Medicine, Cardiovascular Department. Then she was appointed as a Visiting Professor at Transylvania Faculty of Medicine, Brasov, Romania before she started her own group as a Junior Professor at the Medical Faculty Mannheim focusing on cellular and molecular mechanisms controlling vascular quiescence.

Qualifications and Scientific Curriculum

2006-2012

2012

2013-2018

2018-2019

since 2019

PhD studies, Faculty of Medicine, Helsinki University, Finland

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PhD, Faculty of Medicine, Helsinki University, Finland; Faculty of Biology & Geology, Babes-Bolyai University, Cluj-Napoca, Romania

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Postdoctoral Fellow, Yale School of Medicine, New Haven, CT, USA

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Visiting Professor, Faculty of Medicine, Transylvania Univ., Brasov, Romania

 

Junior Professor, Cardiovascular Pharmacology, European Center for AngioScience (ECAS), Medical Faculty Mannheim, Heidelberg University, Germany

Selected publications

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  1. Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, Li J, Genet N, Henrique Geraldo L, Benedetti L, Künzel S, Pibouin-Fragner L, Thomas JL, Eichmann A: Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis. Nat Commun. 10:2350, 2019.

  2. Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel S,  Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Hernando CF, Shulman GI, Sessa WC, Eichmann A: Lacteal junction zippering protects against diet-induced obesity. Science. 361:599-603, 2018.

  3. Ola R, Künzel SH, Zhang F, Genet G, Chakraborty R, Fragner LP, Martin K, Sessa W, Dubrac A, Eichmann A: SMAD4 prevents flow induced arterial-venous malformations by inhibiting Casein Kinase 2. Circulation. 138:2379-2394, 2018

  4. Lee HW* Chong D*, Ola R* Dunworth WP, Meadows S, Ka J, Kaartinen V, Qyang Y, Cleaver O,  Bautch V, Eichmann A, Jin SW: Distinct requirement of Alk2/ACVR1 and Alk3/BMPR1A in bone morphogenetic protein induced retinal angiogenesis. Arterioscler Thromb Vasc Biol. 37:657-663, 2017 (*LHW, CD and OR contributed equally).

  5. Ola R, Dubrac A, Han J, Fang JS, Zhang F,  Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals V, Graupera M, Yan M, Young LH, Oh SP, Eichmann A: PI3 Kinase inhibition improves vascular malformations in mouse models of Hereditary Hemorrhagic Telangiectasia. Nat. Commun. 7, 13650, 2016

  6. Baeyens N* Larrivée B* Ola R, Hayward B, Dubrac A, Huang B, Ross TD, Coon B, Tsarfati M, Tong H, Eichmann A, Schwartz MA. Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia (HHT). J Cell Biol. 214:807-16, 2016 (*BN, LB and OR contributed equally).