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Prof Dr. Philipp Reiners-Koch

Project B2

University Hospital for Dermatology, Venereology and Allergology

European Center for Angioscience (ECAS)

Universitätsmedizin Mannheim, Universität Heidelberg

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philipp.koch(at)umm.de

Philipp Reiners-Koch is a Senior Resident Physician at the Department of Dermatology, Venereology, and Allergy, University Medical Center Mannheim at Heidelberg University. He obtained his MD under the supervision of Monika Wimmer-Röll at the Justus-Liebig University in Giessen. He moved on as a resident physician to the Department of Dermatology, Venereology, and Allergology at the University Medical Center Mannheim.

Qualifications and Scientific Curriculum

2003 - 2004

2004-2010

2011

2011-2016

2016-2017

since 2017

Studies of Physics, Justus-Liebig-University Giessen, Germany

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Medical Degree: Justus-Liebig-University Giessen, Germany and University of Helsinki, Helsinki, Finland

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MD degree: Institute of Anatomy and Cell Biology, Justus Liebig-University Giessen, Germany

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Resident physician, Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Heidelberg University

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Senior Resident physician (Funktionsoberarzt), Dept. Dermatology, University Medical Center Mannheim, Heidelberg University

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Consultant physician (Oberarzt), Dept. Dermatology, University Medical Center Mannheim, Heidelberg University

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Habilitation: Dermatology, Venerology and Allergology, Medical Faculty Mannheim, Heidelberg University

2018

Selected publications

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  1. Heil J*, Olsavszky V*, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber J, Zierow J, Winkler M, Schmid CD, Staniczek S, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S*, Koch PS*: Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat. Commun. 12:6963, 2021. (*equal contribution)

  2. Koch PS*, Sandorski K*, Heil J, Schmid CD, Kürschner SW, Hoffmann J, Winkler M, Staniczek T, De La Torre C, Sticht C, Schledzewski K, Taketo MM, Trogisch F, Heineke J, Géraud C, Goerdt S, Olsavszky V: Imbalanced activation of Wnt-/β-catenin-signaling in liver endothelium alters normal sinusoidal differentiation. Front. Physiol. 29;12:722394, 2021. (*equal contribution)

  3. Koch PS*, Lee KH*, Goerdt S, Augustin HG: Angiodiversity and organotypic functions of sinusoidal endothelial cells. Angiogenesis. 24:289-310, 2021. (*equal contribution) 

  4. Winkler M*, Staniczek T*, Kürschner SW*, Schmid CD*, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C*, Koch PS*, Goerdt S*: Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 74:380-393, 2021. (*equal contribution)

  5. Ni J*, Wang X*, Stojanovic A*, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A: Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. Immunity. 52:1075-1087, 2020. (*equal contribution) 

  6. Wohlfeil SA*, Häfele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Mohammadi MM, Heineke J, Sticht C, Olsavszky V, Koch PS, Géraud C*, Goerdt S*: Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res. 79:598-610, 2019. (*equal contribution)

  7. Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS: Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 68:707-722, 2018. (*equal contribution).

  8. Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest. 127:1099-1114, 2017. (*equal contribution)

  9. Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood. 129:415-419, 2017. (*equal contribution)

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