PD Dr. Philipp-Sebastian Koch

University Hospital for Dermatology, Venereology and Allergology

European Center for Angioscience (ECAS)

Universitätsmedizin Mannheim, Universität Heidelberg

philipp.koch(at)umm.de

Philipp-Sebastian Koch is a Senior Resident Physician at the Department of Dermatology, Venereology, and Allergy, University Medical Center Mannheim at Heidelberg University. He obtained his MD under the supervision of Monika Wimmer-Röll at the Justus-Liebig University in Giessen. He moved on as a resident physician to the Department of Dermatology, Venereology, and Allergology at the University Medical Center Mannheim.

Qualifications and Scientific Curriculum

2003 - 2004

2004-2010

2011

2011-2016

2016-2017

since 2017

Studies of Physics, Justus-Liebig-University Giessen, Germany

Medical Degree: Justus-Liebig-University Giessen, Germany and University of Helsinki, Helsinki, Finland

MD degree: Institute of Anatomy and Cell Biology, Justus Liebig-University Giessen, Germany

Resident physician, Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Heidelberg University

Senior Resident physician (Funktionsoberarzt), Dept. Dermatology, University Medical Center Mannheim, Heidelberg University

Consultant physician (Oberarzt), Dept. Dermatology, University Medical Center Mannheim, Heidelberg University

Habilitation: Dermatology, Venerology and Allergology, Medical Faculty Mannheim, Heidelberg University

2018

Selected publications

  1. Schmid CD, Schledzewski K, Mogler C, Waldburger N, Kalna V, Marx A, Randi AM, Géraud C, Goerdt S, Koch PS: GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. Biochem Biophys Res Commun, 497:32-38, 2018.

  2. Leibing T, Géraud C, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS: Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology, 68:707-722, 2018.

  3. Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantzi H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS: GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene, 627:491-499, 2017.

  4. Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest, 127:1099-114, 2017 (*equal contribution).

  5. Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood, 29:415-9, 2017 (*equal contribution).

  6. Stenzinger A, Endris V, Pfarr N, Andrulis M, Jöhrens K, Klauschen F, Siebolts U, Wolf T, Koch PS, Schulz M, Hartschuh W, Goerdt S, Lennerz JK, Wickenhauser C,  Klapper W, Anagnostopoulos I, Weichert W: Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm. Oncotarget, 5:6404-13, 2014.

  7. Brobeil A, Koch P, Eiber M, Tag C, Wimmer M: The known interactome of PTPIP51 in HaCaT cells-inhibition of kinases and receptors. Int J Biochem Cell Biol, 46:19-31, 2014.

  8. Géraud C, Mogler C, Runge A, Evdokimov K, Lu S, Schledzewski K, Arnold B, Hämmerling G, Koch PS, Breuhahn K, Longerich T, Marx A, Weiss C, Damm F, Schmieder A, Schirmacher P, Augustin HG, Goerdt S: Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival. Liver Int, 33:1428-40, 2013.

  9. Petri MK, Koch P, Stenzinger A, Kuchelmeister K, Nestler U, Paradowska A, Steger K, Brobeil A, Viard M, Wimmer M: PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3β and PTP1B in situ. Histol Histopathol, 26:1531-43, 2011.

  10. Koch P, Petri M, Paradowska A, Stenzinger A, Sturm K, Steger K, Wimmer M: PTPIP51 mRNA and protein expression in tissue microarrays and promoter methylation of benign prostate hyperplasia and prostate carcinoma. Prostate, 69:1751-62, 2009.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University

Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450