Chairman, Department of Neurology,
University Medical Center Mannheim, Heidelberg University &
CCU Neuroimmunology and Brain Tumor Immunology,
German Cancer Research Center Heidelberg
michael.platten(at)umm.de
Michael Platten is head of the CCU Neuroimmun-ology and Bain Tumor Immunology at DKFZ. He obtained his MD from the Department of Neuropathology at the University of Bonn and did his residency at the Department of Neurology, Tübingen University. Michael pursued postdoctoral fellowships in Neuroimmunology at Stanford University and in Neurooncology at Tübingen University before becoming a Helmholtz Young Investigator at the Department of Neurology, University Hospital Heidelberg and German Cancer Research Center. Currently, he is the Chairman of the Department of Neurology at the Medical Faculty Mannheim, Heidelberg University and Head of the CCU Brain Tumor Immunology at DKFZ.
Qualifications and Scientific Curriculum
1998
2002-2004
2006
2010-2015
since 2013
since 2016
MD, University of Bonn, Germany
Postdoctoral Research Fellow, Stanford University, Stanford, USA
Board certified Neurologist
Associate Professor of Neuroimmunology, Heidelberg University, Germany
Head of Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Germany
Full Professor of Neurology and Chairman of the Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Germany
Selected publications
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Bunse L, Pusch S, Bunse T, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger M, Harter P, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende CM, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hänggi D, Dorsch M, Suva M, Niemeyer BA, von Deimling A, Wick W, Platten M: Suppression of antitumor T cell immunity by the oncometabolite R-2-hydroxyglutarate. Nat Med, 24:1192-1203, 2018.
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Kirschbaum K, Sonner JK, Zeller MW, Deumelandt K, Bode J, Sharma R, Krüwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler MU, Wick W, Tews B, Chen JW, Heiland S, Bendszus M, Platten M, Breckwoldt MO: In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis. Proc Natl Acad Sci U S A, 113:13227-232, 2016.
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Bunse L, Schumacher T, Sahm S, Pusch S, Oezen I, Rauschenbach K, Gonzalez M, Solecki G, Osswald M, Capper D, Wiestler B, Winkler F, Herold-Mende C, von Deimling A, Wick W, Platten M: Proximity ligation assay evaluates presentation of mutant isocitrate dehydrogenase 1 in gliomas. J Clin Invest, 125:1-14, 2015.
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Schumacher T, Bunse L, Pusch S, Sahm F, Wiestler B, Quandt J, Menn O, Osswald M, Oezen I, Ott M, Keil M, Balss J, Rauschenbach K, Grabowska AK, Vogler I, Diekmann J, Trautwein N, Eichmüller S, Okun J, Stefanovic S, Riemer AB, Sahin U, Friese M, Beckhove P, von Deimling A, Wick W, Platten M: A vaccine targeting mutant IDH1 induces antitumor immunity. Nature, 512:324-7, 2014.
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Weiler M, Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, Bunse L, Solecki G, Eichwald V, Jugold M, Hodecker S, Osswald M, Meisner C, Hielscher T, Rübmann P, Pfenning PN, Ronellenfitsch M, Kempf T, Schnölzer M, Abdollahi A, Lang F, Bendszus M, von Deimling A, Winkler F, Weller M, Vajkoczy P, Platten M, Wick W: mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Proc Natl Acad Sci U S A, 111:409-14, 2014.
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Lanz TV, Becker S, Osswald M, Bittner S, Schuhmann MK, Opitz CA, Gaikwad S, Wiestler B, Litzenburger UM, Sahm F, Ott M, Iwantscheff S, Grabitz C, Mittelbronn M, von Deimling A, Winkler F, Meuth SG, Wick W, Platten M: Endothelial protein kinase Cβ as a therapeutic target stabilizing blood brain barrier disruption in experimental autoimmune encephalomyelitis. P Proc Natl Acad Sci U S A, 110:14735-40, 2013.
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Wick W, Platten M, Meisner C, Felsberg J, Tabatabai G, Simon M, Nikkhah G, Papsdorf K, Steinbach JP, Sabel M, Combs SE, Vesper J, Braun C, Meixensberger J, Ketter R, Mayer-Steinacker R, Reifenberger G, Weller M: NOA-08 Study Group of Neuro-oncology Working Group (NOA) of German Cancer Society. Lancet Oncol, 13:707-15, 2012.
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Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M: An endogenous ligand of the human aryl hydrocarbon receptor promotes tumor formation. Nature, 478:197-203, 2011.
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Platten M, Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L: Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity, Proc Natl Acad Sci U S A, 106:14948-53, 2009.
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Platten M, Ho PP, Youssef S, Fontoura P, Garren H, Hur EM, Gupta R, Lee LY, Kidd BA, Robinson WH, Sobel RA, Selley ML, Steinman L: Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science, 310:850-5, 2005.