Dr. Katharina Schlereth

Vascular Biology, Medical Faculty Mannheim, Heidelberg University

Vascular Oncology and Metastasis,

German Cancer Research Center, Heidelberg

katharina.schlereth(at)medma.uni-heidelberg.de

Katharina Schlereth received her PhD at the Philipps-University in Marburg under the supervision of Thorsten Stiewe, where she also pursued postdoctoral training before she moved to the Division of Vascular Oncology and Metastasis at the DKFZ for a senior postdoctoral position.

Qualifications and Scientific Curriculum

2007

2011

2011-2013

since 2013

Diploma: Biology, Julius-Maximilians-University Würzburg, Germany

PhD: Molecular Oncology, Philipps-University, Marburg, Germany

Postdoctoral research fellow, Division of Molecular Oncology, Philipps-University Marburg, Germany

Postdoctoral research fellow, Division of Vascular Oncology and Metastasis, DKFZ, Heidelberg and Department of Vascular Biology, Medical Faculty Mannheim, Heidelberg University, Germany

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Selected publications

  1. Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Elife, 7:pii:e34423, 2018.

  2. Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K**, Augustin HG**: Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat commun, 8:16106, 2017 (**joint last authors).

  3. Schlereth K, Heyl C, Krampitz AM, Mernberger M, Finkernagel F, Scharfe M, Jarek M, Leich E, Rosenwald A, Stiewe T: Characterization of the p53 cistrome-DNA binding cooperativity dissects p53's tumor suppressor functions. PLoS Genet, 9:e1003726, 2013.

  4. Timofeev O, Schlereth K, Wanzel M, Braun A, Nieswandt B, Pagenstecher A, Rosenwald A, Elsässer HP, Stiewe T: p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell Rep, 3:1512-25, 2013.

  5. Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y: A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell, 24:242-56, 2013.

  6. Schlereth K, Charles JP, Bretz AC, Stiewe T: Life or death: p53-induced apoptosis requires DNA binding cooperativity. Cell Cycle, 9:4068-76, 2010.

  7. Schlereth K*, Beinoraviciute-Kellner R*, Zeitlinger MK, Bretz AC, Sauer M, Charles JP, Vogiatzi F, Leich E, Samans B, Eilers M, Kisker C, Rosenwald A, Stiewe T: DNA binding cooperativity of p53 modulates the decision between cell cycle arrest and apoptosis. Mol Cell, 38:356-68, 2010 (*equal contribution).

  8. Griesmann H*, Schlereth K*, Krause M, Samans B, Stiewe T: Role of p53 and p73 in suppression of Myc-driven lymphomagenesis. Int J Cancer, 124:502-6, 2009 (*equal contribution).

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450