Joerg_Heineke.jpg

Dept. of Cardiovascular Research,

European Center for Angioscience (ECAS),

Medical Faculty Manheim, Heidelberg University

joerg.heineke(at)medma.uni-heidelberg.de

Jörg Heineke is Head of the Department of Cardiovascular Research. He attended Hanover Medical School. He moved on as a postdoctoral fellow to the laboratory of Jeffry Molkentin at the Department of Molecular Cardiovascular Biology at Cincinnati Children´s Hospital before starting his own junior research group at the Department of Cardiology at Hanover Medical School.

Qualifications and Scientific Curriculum

Medical School, Medizinische Hochschule Hanover

MD, Hanover Medical School, mentor: Prof. H. Drexler

Clinical fellow and member of the research group “Molecular and translational Cardiology”, Department of Cardiology, Hanover Medical School

Postdoctoral Fellow, Department of Molecular Cardiovascular Biology, Cincinnati Children´s Hospital, USA

Junior research group leader, Department of Cardiology, Hanover Medical School

Heisenberg professorship for Experimental Cardiology

Head of the Department of Cardiovascular Research at the Medical Faculty Mannheim of the University of Heidelberg

1993-2000

2001

2001-2003

2004-2008

2008-2012

2012-2017

since 2017

Selected publications

  1. Szaroszyk M, Kattih B, Martin-Garrido A, Trogisch FA, Dittrich GM, Grund G, Abouissa A, Derlin K, Meier M, Holler T, Korf-Klingebiel M, Völker K, Macedo TG, Tortola CP, Boschmann M, Huang N, Froese N, Zwadlo C, Malek Mohammadi M, Luo X, Wagner M, Cordero J, Geffers R, Batkai S, Thum T, Bork N, Nikolaev VO, Müller OJ, Katus HA, El-Amouche A, Kraft T, Springer J, Dobreva G, Wollert KC, Fielitz J, von Haehling S, Kuhn M, Bauersachs J, Heineke J: Skeletal muscle derived Musclin protects the heart during pathological overload. Nat Commun. 13:149, 2022

  2. Dittrich GM, Froese N, Wang X, Kroeger H, Wang H, Szaroszyk M, Malek-Mohammadi M, Cordero J, Keles M, Korf-Klingebiel M, Wollert KC, Geffers R, Mayr M, Conway SJ, Dobreva G, Bauersachs J, Heineke J: Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis. Basic Res Cardiol. 116:26, 2021.

  3. Malek Mohammadi M, Abouissa A, Heineke J: A surgical mouse model of neonatal pressure overload by transverse aortic constriction. Nat Protoc. 16:775-790, 2021.

  4. Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M, Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, Remedios CD, Riechert E, Völkers M, Doroudgar S, Jungmann A, Bauer R, Yin X, Mayr M, Wollert KC, Pich A, Xiao H, Katus HA, Bauersachs J, Müller OJ, Heineke J: TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. EMBO Mol Med. 11:e10018, 2019.

  5. Malek Mohammadi M, Abouissa A, Azizah I, Xie Y, Cordero J, Shirvani A, Gigina A, Engelhardt M, Trogisch FA, Geffers R, Dobreva G, Bauersachs J, Heineke J: Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation. JCI Insight. 5. pii: 128336. doi: 10.1172/jci.insight.128336, 2019.

  6. Scharf GM, Kilian K, Cordero J, Wang Y, Grund A, Hofmann M, Froese N, Wang X, Kispert A, Kist R, Conway SJ, Geffers R, Wollert KC, Dobreva G, Bauersachs J, Heineke J: Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation. JCI Insight. 5:e128336, 2019.

  7. Appari M*, Breitbart A*, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Müller OJ, Bauersachs J, Heineke J: C1q-TNF-Related protein-9 promotes cardiac hypertrophy and failure. Circ Res. 120:66-77, 2017.

  8. Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J: The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol Med. 9:265-279, 2017.

  9. Zwadlo C, Schmidtmann E, Szaroszyk M, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J: Anti-androgenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction. Circulation. 131:1071-81, 2015

  10. Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD: CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 16:872-879, 2010.