Dept. of Cardiovascular Research,

European Center for Angioscience (ECAS),

Medical Faculty Manheim, Heidelberg University

joerg.heineke(at)medma.uni-heidelberg.de

Jörg Heineke is Head of the Department of Cardiovascular Research. He attended Hanover Medical School. He moved on as a postdoctoral fellow to the laboratory of Jeffry Molkentin at the Department of Molecular Cardiovascular Biology at Cincinnati Children´s Hospital before starting his own junior research group at the Department of Cardiology at Hanover Medical School.

Qualifications and Scientific Curriculum

Medical School, Medizinische Hochschule Hanover

MD, Hanover Medical School, mentor: Prof. H. Drexler

Clinical fellow and member of the research group “Molecular and translational Cardiology”, Department of Cardiology, Hanover Medical School

Postdoctoral Fellow, Department of Molecular Cardiovascular Biology, Cincinnati Children´s Hospital, USA

Junior research group leader, Department of Cardiology, Hanover Medical School

Heisenberg professorship for Experimental Cardiology

Head of the Department of Cardiovascular Research at the Medical Faculty Mannheim of the University of Heidelberg

1993-2000

2001

2001-2003

2004-2008

2008-2012

2012-2017

since 2017

Selected publications

  1. Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J: The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol Med, 9:265-79, 2017.

  2. Appari M*, Breitbart A*, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Müller OJ, Bauersachs J, Heineke J: C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure. Circ Res, 120:66-77, 2017 (*equal contribution).

  3. Zwadlo C*, Schmidtmann E*, Szaroszyk M*, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J: Antiandrogenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction. Circulation,131:1071-81, 2015 (*equal contribution).

  4. Froese N*, Kattih B*, Breitbart A, Grund A, Geffers R, Molkentin JD, Kispert A, Wollert KC, Drexler H, Heineke J: GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor {beta}/activin receptor-like kinase 5 signaling. J Biol Chem, 286:5680-90, 2011 (*equal contribution).

  5. Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD: CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med, 16:872-9, 2010.

  6. Heineke J, Auger-Messier M*, Xu J, Sargent M, York A, Welle S, Molkentin JD: Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation, 121:419-25, 2010.

  7. Heineke J, Wollert KC, Osinska H, Sargent MA, York AJ, Robbins J, Molkentin JD: Calcineurin protects the heart in a murine model of dilated cardiomyopathy. J Mol Cell Cardiol, 48:1080-7, 2010.

  8. Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Cromblehol TM, Molkentin JD: Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest, 117:3198-210, 2007.

  9. Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol, 7:589-600, 2006.

  10. Heineke J, Ruetten H, Willenbockel C, Gross SC, Naguib M, Schaefer A, Kempf T, Hilfiker-Kleiner D, Caroni P, Kraft T, Kaiser RA, Molkentin JD, Drexler H, Wollert KC: Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc Natl Acad Sci U S A, 102:1655-60, 2005.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450