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Institute of Vascular Signaling

Centre for Molecular Medicine

Goethe University, Frankfurt


Ingrid Fleming is the Director of the Institute for Vascular Signalling at Frankfurt University. She obtained her PhD from the Louis Pasteur University in Strasbourg and then pursued postdoctoral training at the Institute of Applied Physiology at the Albert-Ludwigs-University in Freiburg, Germany. Then she moved on as Senior Research Fellow in the Institute for Cardiovascular Physiology at the Goethe University Frankfurt before she started her own group in Frankfurt focusing on different forms of signal transduction in vascular cells.

Qualifications and Scientific Curriculum

PhD (Cellular and Molecular Pharmacology) at the Louis Pasteur University, Strasbourg, France

Postdoctoral Fellow, Institute of Applied Physiology, Albert-Ludwigs-University Freiburg

Senior Research Fellow at the Institute for Cardiovascular Physiology, Goethe University Frankfurt

Leader of the Vascular Signal Transduction Group, at the Institute for Cardiovascular Physiology, Goethe University, Frankfurt

Professor of Physiology (Vascular Signalling), at the Goethe University, Frankfurt

Chair for Vascular Signalling and Director of the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt

Chair of the Centre for Molecular Medicine, Goethe University, Frankfurt






since 2008

since 2011

Selected publications

  1. Bibli S-I, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Thombor L, Randriamboavonjy V, Leisegang M, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I: Mapping the endothelial cell sulfhydrome highlights the role of cysteine sulfhydration in integrin signaling. Circulation. 143:935-948, 2021

  2. Delgado Lagos F, Elgheznawy A, Kyselova A, Meyer zu Heringdorf D, Ratiu C, Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, Fleming I: Secreted modular calcium binding protein 1 binds and activates thrombin to account for platelet hyper-reactivity in diabetes. Blood. 137:1641-651, 2021.

  3. Kesavan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I: Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer. Proc Natl Acad Sci U S A, 117:5923-5930, 2020.

  4. Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I: Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition. EMBO J, 38:e100938, 2019.

  5. Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Randriamboavonjy V, Wittig J, Siuda D, Kojonazarov B, Tsilimigras D, Schürmann C, Siragusa M, Luck B, Abdel Malik R, Filis K A, Zografos G, Chen C, Wang D W, Pfeilschifter J, Brandes R P, Szabo C, Papapetropoulos A, Fleming I: Cystathionine gamma-lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherogenesis. Circulation, 139:101-114, 2019.

  6. Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mos J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I: Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature, 552:248-52, 2017.

  7. Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, Ansari N, Pampaloni F, Wingert S, Rieger MA, Wittig I, Fisslthaler B, Fleming I: AMP-activated protein kinase a2 in neutrophils regulates hypoxia-inducible factor-1a and a network of proteins affecting metabolism and vascular repair after ischemia. Circ Res, 120:99-109, 2017.

  8. Elgheznawy A, Shi L, Hu J, Wittig I, Laban H, Pircher J, Mann A, Provost P, Randriamboavonjy V, Fleming I: Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes. Circ Res, 117:157-65, 2015.

  9. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I§, Busse R: Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature. 401:493-497, 1999. (§Corresponding author)

  10. Fleming I, Gray GA, Julou-Schaeffer G, Parratt JR, Stoclet J-C: Incubation with endotoxin activates the L-arginine pathway in vascular tissue. Biochem Biophys Res Commun. 171:562-568, 1990.

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