Institute of Vascular Signaling

Centre for Molecular Medicine

Goethe University, Frankfurt

fleming(at)em.uni-frankfurt.de

Ingrid Fleming is the Director of the Institute for Vascular Signalling at Frankfurt University. She obtained her PhD from the Louis Pasteur University in Strasbourg and then pursued postdoctoral training at the Institute of Applied Physiology at the Albert-Ludwigs-University in Freiburg, Germany. Then she moved on as Senior Research Fellow in the Institute for Cardiovascular Physiology at the Goethe University Frankfurt before she started her own group in Frankfurt focusing on different forms of signal transduction in vascular cells.

Qualifications and Scientific Curriculum

PhD (Cellular and Molecular Pharmacology) at the Louis Pasteur University, Strasbourg, France

Postdoctoral Fellow, Institute of Applied Physiology, Albert-Ludwigs-University Freiburg

Senior Research Fellow at the Institute for Cardiovascular Physiology, Goethe University Frankfurt

Leader of the Vascular Signal Transduction Group, at the Institute for Cardiovascular Physiology, Goethe University, Frankfurt

Professor of Physiology (Vascular Signalling), at the Goethe University, Frankfurt

Chair for Vascular Signalling and Director of the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt

Chair of the Centre for Molecular Medicine, Goethe University, Frankfurt

1991

1991-1993

1993-1999

1999-2004

2004-2008

since 2008

since 2011

Selected publications

  1. Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Randriamboavonjy V, Wittig J, Siuda D, Kojonazarov B, Tsilimigras D, Schürmann C, Siragusa M, Luck B, Abdel Malik R, Filis K A, Zografos G, Chen C, Wang D W, Pfeilschifter J, Brandes R P, Szabo C, Papapetropoulos A, Fleming I: Cystathionine gamma-lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherogenesis. Circulation, in press, 2018.

  2. Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mos J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I: Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature, 552:248-52, 2017.

  3. Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, Ansari N, Pampaloni F, Wingert S, Rieger MA, Wittig I, Fisslthaler B, Fleming I: AMP-activated protein kinase a2 in neutrophils regulates hypoxia-inducible factor-1a and a network of proteins affecting metabolism and vascular repair after ischemia. Circ Res, 120:99-109, 2017.

  4. Elgheznawy A, Shi L, Hu J, Wittig I, Laban H, Pircher J, Mann A, Provost P, Randriamboavonjy V, Fleming I: Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes. Circ Res, 117:157-65, 2015.

  5. Hu J, Popp R, Frömel T, Ehling M, Awwad K, Adams RH, Hammes HP, Fleming I: Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocos-apentaenoic acid. J Exp Med, 211:281-95, 2014.

  6. Kohlstedt K, Trouvain C, Boettger T, Shi L, Fisslthaler B, Fleming I: AMP-activated protein kinase regulates endothelial cell angiotensin-converting enzyme expression via p53 and the post-trans-criptional regulation of microRNA-143/145. Circ Res, 112:1150-8, 2013.

  7. Shi L, Fisslthaler B, Zippel N, Frömel T, Hu J, Elgheznawy A, Heide H, Popp R, Fleming I: MicroRNA-223 antagonizes angiogenesis by targeting β integrin and preventing growth factor signaling in endothelial cells. Circ Res, 13:1320-30, 2013.

  8. Frömel T, Jungblut B, Hu J, Trouvain C, Barbosa Sicard E, Popp R, Liebner S, Dimmeler S, Hammock BD, Fleming I: Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols. Proc Natl Acad Sci U S A, 109:9995-10000, 2012.

  9. Randriamboavonjy V, Isaak J, Elgheznawy A, Pistrosch F, Frömel T, Yin X, Badenhoop K, Heide H, Mayr M, Fleming I: Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes. Blood, 120:415-23, 2012.

  10. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R: Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature, 401:493-7, 1999

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450