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Prof. Dr. Holger Gerhardt

Project B6

 

Max-Delbrück-Center for Molecular Medicine

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holger.gerhardt(at)mdc-berlin.de

Holger Gerhardt is Professor in Experimental Cardiovascular Research at the Charité and BIH in Berlin and Head of the Integrative Vascular Biology Laboratory at the MDC. He obtained his PhD with Hartwig Wolburg at the University of Tübingen. Following a post-doc with Christer Betsholtz at the University of Göteborg, he set up his own group at the Cancer Research UK London Research Institute, and later a joint-venture with the VIB, Leuven. He is currently the Speaker of the German Cardiovascular Research Center (DZHK) at the Partnersite Berlin.

Qualifications and Scientific Curriculum

PhD in Cell Biology, University of Tübingen

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Postdoctoral fellow, Department of Medical Biochemistry, University of Göteborg, Sweden,

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Head of the Laboratory, Vascular Biology, Cancer Research UK London Research Institute, UK

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Head of the Laboratory, Senior Group Leader, Vascular Biology, Cancer Research UK London Research Institute, UK

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Independent Consultant Group Leader, Vascular Patterning Laboratory, CCB, VIB KU Leuven, Belgium

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Head of the Integrative Vascular Biology Laboratory, Max-Delbrück Center for Molecular Medicine, Berlin Buch, Germany

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Speaker of the German Center for Cardiovascular Research (DZHK), Berlin Partnersite

2000

2000-2004

2004-2009

2009-2014

since 2010

since 2014

since 2018

Selected publications

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  1. Zhao X, Nedvetsky P, Stanchi F, Vion AC, Popp O, Zühlke K, Dittmar G, Klussmann E, Gerhardt H: Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1. Elife, 8:e46380, 2019.

  2. Geudens I, Coxam B, Alt S, Gebala V, Vion AC, Meier K, Rosa A, Gerhardt H: Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine-tuning. Development, 146:dev181024, 2019.

  3. Vion AC, Alt S, Klaus-Bergmann A, Szymborska A, ÄZheng T, Perovic T, Hammoutene A, Oliveira MB, Bartels-Klein E, Hollfinger I, Rautou PE, Bernabeu MO, Gerhardt H: Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression. J Cell Biol, 217:1651-65, 2018.

  4. Neto F, Klaus-Bergmann A, Ong YT, Alt S, Vion AC, Szymborska A, Carvalho JR, Hollfinger I, Bartels-Klein E, Franco CA, Potente M, Gerhardt H: YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development. Elife, 7.pii:e31037, 2018.

  5. Gebala V, Collins R, Geudens I, Phng LK, Gerhardt H: Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo. Nat Cell Biol, 18:443-50, 2016.

  6. Phng LK, Gebala V, Bentley K, Philippides A, Wacker A, Mathivet T, Sauteur L, Stanchi F, Belting HG, Affolter M, Gerhardt H: Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization. Dev Cell, 32:123-32, 2015.

  7. Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, Westrom S, Claesson-Welsh L, Vestweber D, Gerhardt H: The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol, 16:309-21, 2014.

  8. Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM, Rosewell I, Busse M, Thurston G, Medvinsky A, Schulte-Merker S, Gerhardt H: Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol, 12:943-53, 2010.

  9. Phng LK, Potente M, Leslie JD, Babbage J, Nyqvist D, Lobov I, Ondr JK, Rao S, Lang RA, Thurston G, Gerhardt H: Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell, 16:70-82, 2009.

  10. Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H*, Vanhaesebroeck B*: Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature, 453:662-6, 2008 (*corresponding author).

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