Hellmut Augustin is Professor of Vascular Biology at the Medical Faculty Mannheim of Heidelberg University and Head of the Division for Vascular Oncology and Metastasis Research at the German Cancer Research Center in Heidelberg. Trained as a Veterinary Pathologist at the School of Veterinary Medicine Hannover and as PhD in Experimental Pathology at Cornell University, Ithaca, USA, he worked as Assistant Professor at the University of Göttingen and as Department Head at the Tumor Biology Center in Freiburg. He is Director of the European Center for Angoscience.
Qualifications and Scientific Curriculum
Veterinary Medicine, School of Veterinary Medicine Hannover, Germany
Residency and graduate training in Veterinary Pathology, Hannover, Germany
PhD in Exp. Pathology, Cornell University, Ithaca, NY, USA
Research Assistant Professor, University of Göttingen, Germany
Head, Dept. of Vascular Biology & Angiogenesis Research, Tumor Biology Center, Freiburg, Germany
Aventis Foundation-endowed Chair for Vascular Biology and Angiogenesis Research, Medical Faculty Mannheim (CBTM), Heidelberg University, and German Cancer Research Center, Heidelberg, Germany
Full Professor and Chair of the Department of Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim, Heidelberg University, and German Cancer Research Center (DKFZ), Heidelberg, Germany
Founding Director, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University
Singhal M, Gengenbacher N, La Porta S, Gehrs S, Shi J, Kamiyama M, Bodenmiller DM, Fischl A, Schieb B, Besemfelder E, Chintharlapalli S, Augustin HG: Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking antibody. EMBO Mol Med, 12:e11164, 2020.
Singhal S*, Liu X*, Inverso D, Jiang K, Dai J, He H, Bartels S, Li W, Abdul Pari, AA, Gengenbacher N, Besemfelder E, Hui L, Augustin HG*, Hu J*: Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med, 215: 2497-2508, 2018.
Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C*, Augustin HG*: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Elife, pii:e34423, 2018.
La Porta S*, Roth L*, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, Augustin HG: Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest, 128: 834-845, 2018.
Teichert M*, Milde L*, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG: Pericyte-expressed Tie2 controls vessel maturation. Nat Commun. 8:16106, 2017.
Scholz B*, Korn C*, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG: Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling. Dev Cell, 36:79-93, 2016.
Hu J*, Srivastava K*, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, and Augustin HG: Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science, 343:416-9, 2014.
Srivastava, K*, Hu J*, Korn C, Savant S, Teichert M, Kapel S, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG: Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell, 26:880-95, 2014.
Felcht, M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, and Augustin HG: Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest, 122:1991-2005. PMID: 22585576, 2012.
Alajati A, Laib AM, Weber H, Boos AM, Bartol A, Ikenberg K, Korff T, Zentgraf H, Obodozie C, Graeser R, Christian S, Finkenzeller G, Stark GB, Héroult M, Augustin HG: Spheroid-based engineering of a human vasculature in mice. Nat Methods, 5:439-45, 2008.