European Center for Angioscience (ECAS)
Medical Faculty Mannheim, Heidelberg University
German Cancer Research Center Heidelberg


augustin(at)angiogenese.de

Hellmut Augustin is Professor of Vascular Biology at the Medical Faculty Mannheim of Heidelberg University and Head of the Division for Vascular Oncology and Metastasis Research at the German Cancer Research Center in Heidelberg. Trained as a Veterinary Pathologist at the School of Veterinary Medicine Hannover and as PhD in Experimental Pathology at Cornell University, Ithaca, USA, he worked as Assistant Professor at the University of Göttingen and as Department Head at the Tumor Biology Center in Freiburg. He is Director of the European Center for Angoscience.

Qualifications and Scientific Curriculum

Veterinary Medicine, School of Veterinary Medicine Hannover, Germany

Residency and graduate training in Veterinary Pathology, Hannover, Germany

PhD in Exp. Pathology, Cornell University, Ithaca, NY, USA

Research Assistant Professor, University of Göttingen, Germany

Head, Dept. of Vascular Biology & Angiogenesis Research, Tumor Biology Center, Freiburg, Germany

 

Aventis Foundation-endowed Chair for Vascular Biology and Angiogenesis Research, Medical Faculty Mannheim (CBTM), Heidelberg University, and German Cancer Research Center, Heidelberg, Germany

Full Professor and Chair of the Department of Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim, Heidelberg University, and German Cancer Research Center (DKFZ), Heidelberg, Germany

Founding Director, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University

1978-1984

1984-1987

1988-1992

1992-2001

2001-2006

2006-2016

since 2016

since 2017

Selected publications

  1. Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Elife, 7:pii:e34423, 2018.

  2. La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, Augustin HG: Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest, 128:834-45, 2018.

  3. Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG: Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun, 8:16106, 2017.

  4. Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG: Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling. Dev Cell, 36:79-93, 2016.

  5. Hu J, Srivastava K, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, and Augustin HG: Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science, 343:416-9, 2014.

  6. Srivastava, K, Hu J, Korn C, Savant S, Teichert M, Kapel S, Jugold M, Besemfelder E, Thomas M,  Pasparakis M, Augustin HG: Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell, 26:880-95, 2014.

  7. Felcht, M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, and Augustin HG: Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest, 122:1991-2005. PMID: 22585576, 2012.

  8. Alajati A, Laib AM, Weber H, Boos AM, Bartol A, Ikenberg K, Korff T, Zentgraf H, Obodozie C, Graeser R, Christian S, Finkenzeller G, Stark GB, Héroult M, Augustin HG: Spheroid-based engineering of a human vasculature in mice. Nat Methods, 5:439-45, 2008.

  9. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG: The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood, 103:4150-6, 2004.

  10. Eberhard A, Kahlert S, Goede V, Hemmerlein B, Plate KH, Augustin HG: Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res, 60:1388-93, 2000.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450