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Prof. Dr. Hellmut Augustin

Project C5 | Project Z1

European Center for Angioscience (ECAS)
Medical Faculty Mannheim, Heidelberg University
German Cancer Research Center Heidelberg

 


augustin(at)angiogenese.de

Hellmut Augustin is Professor of Vascular Biology at the Medical Faculty Mannheim of Heidelberg University and Head of the Division for Vascular Oncology and Metastasis Research at the German Cancer Research Center in Heidelberg. Trained as a Veterinary Pathologist at the School of Veterinary Medicine Hannover and as PhD in Experimental Pathology at Cornell University, Ithaca, USA, he worked as Assistant Professor at the University of Göttingen and as Department Head at the Tumor Biology Center in Freiburg. He is Director of the European Center for Angoscience.

Qualifications and Scientific Curriculum

Veterinary Medicine, School of Veterinary Medicine Hannover, Germany

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Residency and graduate training in Veterinary Pathology, Hannover, Germany

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PhD in Exp. Pathology, Cornell University, Ithaca, NY, USA

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Research Assistant Professor, University of Göttingen, Germany

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Head, Dept. of Vascular Biology & Angiogenesis Research, Tumor Biology Center, Freiburg, Germany

 

Aventis Foundation-endowed Chair for Vascular Biology and Angiogenesis Research, Medical Faculty Mannheim (CBTM), Heidelberg University, and German Cancer Research Center, Heidelberg, Germany

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Full Professor and Chair of the Department of Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim, Heidelberg University, and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Founding Director, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University

1978-1984

1984-1987

1988-1992

1992-2001

2001-2006

2006-2016

since 2016

since 2017

Selected publications

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  1. Singhal M*, Gengenbacher N*, Abdul Pari AA*, Kamiyama M, Hai L, Kuhn BJ, Kallenberg DM, Kulkarni SR, Camilli C, Preuss SF, Leuchs B, Mogler C, Espinet E, Besemfelder E, Heide D, Heikenwalder M, Sprick MR, Trumpp A, Krijgsveld J, Schlesner M, Hu J, Moss SE, Greenwood J, Augustin HG: Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. Science Transl Med. 13:eabe6805, 2021. (*equal contribution)

  2. Gengenbacher N*, Singhal M*, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HG: Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov. 11:424-45, 2021.

  3. Inverso D*, Shi J*, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Argos Vélez P, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG: A spatial vascular transcriptomic, proteomic and phosphoproteomic atlas unveils an angiocrine Tie Wnt signaling axis in the liver. Dev Cell. 56:1677-1693, 2021. (*equal contribution)

  4. Singhal M, Gengenbacher N, La Porta S, Gehrs S, Shi J, Kamiyama M, Bodenmiller DM, Fischl A, Schieb B, Besemfelder E, Chintharlapalli S, Augustin HG: Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking anti¬body. EMBO Mol Med. 12:e11163, 2020

  5. Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. eLife. 7:e34423, 2018.

  6. La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, Augustin HG: Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest. 128:834-845, 2018.

  7. Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG: Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun. 8:16106, 2017.

  8. Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG: Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca(2+)/NFAT signaling. Dev Cell. 36:79-93, 2016.

  9. Hu J*, Srivastava K*, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG: Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science. 343:416-9, 2014. (*equal contribution)

  10. Srivastava K*, Hu J*, Korn C, Savant S, Teichert M, Kapel S, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG: Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemo¬therapy limits metastatic growth. Cancer Cell. 26:880-95, 2014. (*equal contribution)

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