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Prof. Dr. Gergana Dobreva

Project A3

Department of Anatomy and Developmental Biology

European Center for Angioscience (ECAS)

Medical Faculty Mannheim, Heidelberg University

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gergana.dobreva(at)medma.uni-heidelberg.de

Gergana Dobreva is a Professor of Anatomy and Developmental Biology at the Medical Faculty Mannheim of the Heidelberg University. She obtained her PhD at the Department of Biochemistry of the Ludwig Maximilian University in Munich, followed by a postdoctoral work in the laboratory of Rudolf Grosschedl at the Gene Center at the Ludwig Maximilian University and the Max-Planck Institute of Immunology and Epigenetics. Then she moved on to pursue further postdoctoral training at the Klinikum rechts der Isar of the Technical University in Munich, before she started her independent Emmy-Noether Junior Research Group at the Max Planck Institute for Heart and Lung Research in Bad Nauheim. In 2012 she was appointed as a Professor of Basic Mechanisms of Stem Cell Biology at the Goethe University in Frankfurt. Since 2017 she is heading the Department of Anatomy and Developmental Biology at the Medical Faculty Mannheim.

Qualifications and Scientific Curriculum

Biological Faculty of the University of Sofia, St. Kliment Ohridski, Bulgaria

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PhD:Biochemistry, Ludwig Maximilian University, Munich

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Postdoctoral Fellow, Gene Center, Ludwig Maximilian University, Munich and Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

 

Postdoctoral Fellow, Klinikum rechts der Isar, Technical University, Munich and German Heart Centre, Munich

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Independent Junior Group Leader (Emmy Noether programme), Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

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Professor of Basic Mechanisms of Stem Cell Biology, Goethe University, Frankfurt/ MPI for Heart and Lung Research, Bad Nauheim, Germany

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Professor of Anatomy and Developmental Biology, Medical Faculty Mannheim, Heidelberg University

1994-1999

2000-2004

2004-2006

2006-2007

2008-2012

2012-2016

since 2017

Selected publications

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  1. Jing Y, Ren Y, Witzel HR, Dobreva G: A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis. Stem Cell Reports. 16:1894-1905, 2021.

  2. Schott J, Reitter S, Lindner D, Grosser J, Bruer M, Shenoy A, Geiger T, Mathes A, Dobreva G, Stoecklin G: Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density. Nat Methods. 18:1068-1074, 2021.

  3. Jia Y, Vong JS, Asafova A, Garvalov BK, Caputo L, Cordero J, Singh A, Boettger T, Günther S, Fink L, Acker T, Barreto G, Seeger W, Braun T, Savai R, Dobreva G: Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET. J Exp Med, 216:1377-1395, 2019.

  4. Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G: Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res, 29:486-501, 2019.

  5. Singh I, Contreras A, Cordero J, Rubio K, Dobersch S, Günther S, Jeratsch S, Mehta A, Krüger M, Graumann J, Seeger W, Dobreva G, Braun T, Barreto G: MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization, Nat Genet, 50:990-1001, 2018.

  6. Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T: Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 127:2235-2248, 2017.

  7. Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G: The Isl1/Ldb1 complex orchestrates genome-wide chromatin organization to instruct differentiation of multipotent cardiac progenitors. Cell Stem Cell. 17:287-99, 2015.

  8. Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S: Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. Circ Res, 113:856-62, 2013.

  9. Witzel HR, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G: The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell, 23:58-70, 2012.

  10. Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, and Grosschedl R. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 125:971-86, 2006.

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