Department of Anatomy and Developmental Biology

European Center for Angioscience (ECAS)

Medical Faculty Mannheim, Heidelberg University

gergana.dobreva(at)medma.uni-heidelberg.de

Gergana Dobreva is a Professor of Anatomy and Developmental Biology at the Medical Faculty Mannheim of the Heidelberg University. She obtained her PhD at the Department of Biochemistry of the Ludwig Maximilian University in Munich, followed by a postdoctoral work in the laboratory of Rudolf Grosschedl at the Gene Center at the Ludwig Maximilian University and the Max-Planck Institute of Immunology and Epigenetics. Then she moved on to pursue further postdoctoral training at the Klinikum rechts der Isar of the Technical University in Munich, before she started her independent Emmy-Noether Junior Research Group at the Max Planck Institute for Heart and Lung Research in Bad Nauheim. In 2012 she was appointed as a Professor of Basic Mechanisms of Stem Cell Biology at the Goethe University in Frankfurt. Since 2017 she is heading the Department of Anatomy and Developmental Biology at the Medical Faculty Mannheim.

Qualifications and Scientific Curriculum

Biological Faculty of the University of Sofia, St. Kliment Ohridski, Bulgaria

PhD:Biochemistry, Ludwig Maximilian University, Munich

Postdoctoral Fellow, Gene Center, Ludwig Maximilian University, Munich and Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

 

Postdoctoral Fellow, Klinikum rechts der Isar, Technical University, Munich and German Heart Centre, Munich

Independent Junior Group Leader (Emmy Noether programme), Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

Professor of Basic Mechanisms of Stem Cell Biology, Goethe University, Frankfurt/ MPI for Heart and Lung Research, Bad Nauheim, Germany

Professor of Anatomy and Developmental Biology, Medical Faculty Mannheim, Heidelberg University

1994-1999

2000-2004

2004-2006

2006-2007

2008-2012

2012-2016

since 2017

Selected publications

  1. Singh I, Contreras A, Cordero J, Rubio K, Dobersch S, Günther S, Jeratsch S, Mehta A, Krüger M, Graumann J, Seeger W, Dobreva G, Braun T, Barreto G: MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization, Nat Genet, doi:10.1038, 2018.

  2. Witzel HR, Cheedipudi S, Gao R, Stainier DY, Dobreva G: Isl2b regulates anterior second heart field development in zebrafish. Sci Rep, 7:41043, 2017.

  3. Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IWF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G: The Isl1/Ldb1 complex orchestrates genome-wide chromatin organization to instruct differentiation of multipotent cardiac progenitors. Cell Stem Cell, 17: 287-99, 2015.

  4. Cheedipudi S, Genolet O, Dobreva G: Epigenetic inheritance of cell fates during embryonic development. Front Genet, 5:19, 2014.

  5. Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S: Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. Circ Res, 113:856-62, 2013.

  6. Witzel HR, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G: The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell, 23:58-70, 2012.

  7. Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R: Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner. Cell Stem Cell, 7:496-507, 2010.

  8. Dobreva G, Braun T: The yin and yang of polycomb repression in regenerating muscle. Cell Stem Cell, 7:422-4, 2010.

  9. Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, Grosschedl R: SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell, 125:971-86, 2006.

  10. Dobreva G, Dambacher J, Grosschedl R: SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. Genes Dev, 17:3048-61, 2003

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450