Didier_Stainier.jpg

Director of the Max Planck Institute for Heart and Lung Research

Director of the Department of Developmental Genetics

Max Planck Institute for Heart and Lung Research, Bad Nauheim

 

didier.stainier(at)mpi-bn.mpg.de

Didier Stainier obtained his PhD at Harvard University in Cambridge, USA, under the supervision of Walter Gilbert. He then moved to the laboratory of Mark Fishman at Massachusetts General Hospital at Harvard Medical School in Boston to pursue postdoctoral research before starting his own group in the Department of Biochemistry and Biophysics at the University of California, San Francisco where he became a Professor. Currently, he is Director of the Department of Developmental Genetics at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, and Professor of Biology at Goethe University in Frankfurt.

Qualifications and Scientific Curriculum

1984-1990

1990-1994

1995-2000

2000-2003

2003-2012

since 2012

Harvard University, Cambridge, MA, USA; PhD student Biochemistry and Molecular Biology

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Postdoctoral fellow

University of California, San Francisco, USA; Assistant Professor Department of Biochemistry and Biophysics

University of California, San Francisco, USA; Associate Professor Department of Biochemistry and Biophysics

University of California, San Francisco, USA; Professor Department of Biochemistry and Biophysics

Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany; Director Department of Developmental Genetics

Goethe University, Frankfurt, Germany; Professor of Biology

since 2015

Selected publications

  1. Priya R, Allanki S, Gentile A, Mansingh S, Uribe V, Maischein HM, Stainier DYR: Tension heterogeneity directs form and fate to pattern the myocardial wall. Nature. 588:130-134, 2020.

  2. El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR: Genetic compensation triggered by mutant mRNA degradation. Nature. 568:193-197, 2019.

  3. Reischauer S, Stone O, Villasenor A, Jin S, Chi N, Martin M, Lee MT, Fukuda N, Marass M, Fiddes I, Kuo T, Chung WS, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DYR: Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 535:294-298, 2016.

  4. Rossi A, Kontarakis Z, Gerri C, Nolte H, Hölper S, Krüger M, Stainier DYR: Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature. 524:230-233, 2015.

  5. Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DYR: Arterial/Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation. Science. 326:294-298, 2009.

  6. Vogeli KM, Jin S-W, Martin GR, Stainier DYR: A common progenitor for hematopoietic and endothelial lineages in the zebrafish gastrula. Nature. 443:337-339, 2006.

  7. Ober EA, Verkade H, Field HA, Stainier DYR: Mesodermal Wnt2b signaling positively regulates liver specification. Nature. 442:688-691, 2006.

  8. Horne-Badovinac S, Rebagliati M, Stainier DYR: A cellular framework for gut looping morphogenesis in zebrafish. Science. 302:662-665, 2003.

  9. Walsh EC, Stainier DYR: UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Science. 293:1670-1673, 2001.

  10. Kupperman E, An S, Osborne N, Waldron S, Stainier DYR: A sphingosine 1-phosphate receptor regulates cell migration during vertebrate heart development. Nature. 406:192-195, 2000.