Director of the Max Planck Institute for Heart and Lung Research

Director of the Department of Developmental Genetics

Max Planck Institute for Heart and Lung Research, Bad Nauheim

 

didier.stainier(at)mpi-bn.mpg.de

Didier Stainier obtained his PhD at Harvard University in Cambridge, USA, under the supervision of Walter Gilbert. He then moved to the laboratory of Mark Fishman at Massachusetts General Hospital at Harvard Medical School in Boston to pursue postdoctoral research before starting his own group in the Department of Biochemistry and Biophysics at the University of California, San Francisco where he became a Professor. Currently, he is Director of the Department of Developmental Genetics at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, and Professor of Biology at Goethe University in Frankfurt.

Qualifications and Scientific Curriculum

1984-1990

1990-1994

1995-2000

2000-2003

2003-2012

since 2012

Harvard University, Cambridge, MA, USA; PhD student Biochemistry and Molecular Biology

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Postdoctoral fellow

University of California, San Francisco, USA; Assistant Professor Department of Biochemistry and Biophysics

University of California, San Francisco, USA; Associate Professor Department of Biochemistry and Biophysics

University of California, San Francisco, USA; Professor Department of Biochemistry and Biophysics

Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany; Director Department of Developmental Genetics

Goethe University, Frankfurt, Germany; Professor of Biology

since 2015

Selected publications

  1. Beisaw A, Kuenne C, Guenther S, Dallmann J, Wu CC, Bentsen M, Looso M, Stainier DYR: AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration. Circ Res. 2020 Jun 5;126(12):1760-1778.

  2. El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR: Genetic compensation triggered by mutant mRNA degradation. Nature, 568:193-197, 2019.

  3. Stone OA, El-Brolosy M, Wilhelm K, Liu X, Romão AM, Grillo E, Lai JKH, Günther S, Jeratsch S, Kuenne C, Lee IC, Braun T, Santoro MM, Locasale JW, Potente M, Stainier DYR: Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nat Commun, 9:4077, 2018.

  4. Reischauer S, Stone O, Villasenor A, Jin SW, Chi N, Martin M, Lee MT, Fukuda N, Marass M, Fiddes I, Kuo T, Chung WS, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O and Stainier DYR: Positional cloning of cloche, a gene that drives endothelial and hematopoietic lineage specification. Nature, 535:294-98, 2016.

  5. Rossi A, Kontarakis Z, Gerri C, Nolte H, Hölper S, Krüger M and Stainier DYR:  Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature, 524:230-3, 2015. 

  6. Arrenberg AB, Stainier DYR, Baier H and Huisken J: Optogenetic control of cardiac function. Science, 330:971-4, 2010.

  7. Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM and Stainier DYR:  Arterial/venous segregation by selective cell sprouting: An alternative mode of blood vessel vormation. Science, 326:294-8, 2009.

  8. Bagnat M, Cheung ID, Mostov KE and Stainier DYR: Genetic control of single lumen formation in the zebrafish gut. Nat Cell Biol, 9:954-60, 2007.

  9. Vogeli KM, Jin S-W, Martin GR and Stainier DYR: A common progenitor for hematopoietic and endothelial lineages in the zebrafish gastrula. Nature, 443:337-9, 2006.

  10. Ober EA, Verkade H, Field HA and Stainier DYR: Mesodermal Wnt2b signaling positively regulates liver specification. Nature, 442:688-91, 2006.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University

Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450