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Prof. Dr. Cyrill Géraud

Project B3

Department of Dermatology, Venereology and Allergology

European Center for Angioscience (ECAS),

University Medical Center and Medical Faculty Mannheim,
Heidelberg University

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cyrill.geraud(at)umm.de

Cyrill Géraud is an Associate professor for Clinical and Molecular Dermatology, at the Medical Faculty Mannheim at Heidelberg University and the Vice Speaker of the research training group RTG/GRK2099. He attended the Albert-Ludwigs University Medical School in Freiburg wehre he also received his MD. He then moved on as a resident Resident physician to the Department of Dermatology, Venereology and Allergology at the University Medical Center Mannheim. Now he is Head of the Section of Clinical and Molecular Dermatology

Qualifications and Scientific Curriculum

Medical Degree: Albert-Ludwigs University Medical School Freiburg, Germany with extramural electives in San Diego, CA, USA and Tampa, FL, USA

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MD, Albert-Ludwigs-University Freiburg

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Resident physician, Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Heidelberg University

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Group leader research group “Organ-specific microvessels” with Prof. Dr. Sergij Goerdt, Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Heidelberg University

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Consultant physician, Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Heidelberg University

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Habilitation: Dermatology and Venereology, (Medical Faculty Mannheim, Heidelberg University), mentor: Prof. Dr. S. Goerdt)

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Associate professor for Clinical and Molecular Dermatology and Deputy Director, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, Heidelberg University

2001-2007

2009

2008-2013

2014

2009 - 2017

since 2013

since 2017

Selected publications

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  1. Wohlfeil SA*, Häfele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Malek Mohammadi M, Heineke J, Sticht C, Olsavszky V, Koch PS, Géraud C*, Goerdt S*: Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res, 79:598-610, 2019.

  2. Leibing T, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S*, Koch PS: Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice, Hepatology, doi:10.1002, 2017 (*corresponding author).

  3. Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest, 127:1099-114, 2017 (*equal contribution).

  4. Koch PS, Olsavszky V, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood, 129:415-9, 2017 (*equal contribution).

  5. Baum C, Weiss C, Gebhardt C, Utikal J, Marx A, Koenen W, Géraud C: Sentinel node metastasis mitotic rate (SN-MMR) as a prognostic indicator of rapidly progressing disease in patients with sentinel node-positive melanomas. Int J Cancer, 140:1907-17, 2017.

  6. Evdokimov K, Biswas S, Schledzewski K, Winkler M, Gorzelanny C, Schneider SW, Goerdt S, Géraud C: Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing. Biochem Biophys Res Commun, 475:342-9, 2016.

  7. Biswas S, Adrian M, Evdokimov K, Schledzewski K, Weber J, Winkler M, Goerdt S, Géraud C: Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages. Biochem Biophys Res Commun, 464:1078-83, 2015.

  8. Géraud C*, Mogler C*, Runge A, Evdokimov K, Lu S, Schledzewski K, Arnold B, Hämmerling G, Koch P, Breuhahn K, Longerich T, Marx A, Weiss C, Damm F, Schmieder A, Schirmacher P, Augustin HG, Goerdt S: Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumorous liver correlates with increased survival. Liver Int, 33:1428-40, 2013.

  9. Géraud C*, Evdokimov K*, Straub BK, Peitsch WK, Demory A, Dörflinger Y, Schledzewski K, Schmieder A, Schemmer P, Augustin HG, Schirmacher P, Goerdt S: Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PLoS ONE, 7:e34206, 2012.

  10. Schledzewski K*, Géraud C*, Arnold B, Wang S, Grone HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schonhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S: Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest, 121:703-14, 2011 (*equal contribution).