Prof. Dr. Carmen Ruiz de Almodóvar
Dept. Vascular Dysfunktion
European Center for Angioscience (ECAS)
Institute for Transfusion Medicine/Immunology
Faculty of Medicine Mannheim, Heidelberg University
Carmen.ruizdealmodovar(at)medma.uni-heidelberg.de
Carmen Ruiz de Almodóvar obtained her PhD in Biochemistry from the University of Granada. She then moved on to pursue postdoctoral training in the laboratory of Peter Carmeliet at the Vesalius Research Center in Leuven before starting her own junior research group at the Biochemistry Center in Heidelberg. Since September 2018 she is a full professor for Vascular Dysfunction at the Medical Faculty Mannheim.
Qualifications and Scientific Curriculum
1994-1999
1999-2004
2004-2011
2011-2018
since 2018
Biochemistry, University of Granada, Spain
PhD student, CSIC – University of Granada, Spain
Postdoctoral fellow, Vesalius Research Center (VRC), VIB – KU, Leuven, Belgium
Junior Group leader at the Biochemistry Center (BZH) of University of Heidelberg, Germany
W3 Professor for Vascular Dysfunction
Selected publications
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Wang X, Freire Valls A, Schermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann L, Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C: YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell, 42:462-78, 2017.
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Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodovar C: Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun, 8:14583, 2017.
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Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A: CNS Macrophages Control Neurovascular Development via CD95L, Cell Rep,19:1378-93, 2017.
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Segura I, Lange C, Knevels E, Moskalyuk A, Pulizzi R, Eelen G, Chaze T, Tudor C, Boulegue C, Holt M, Daelemans D, Matondo M, Ghesquière B, Giugliano M, Ruiz de Almodovar C, Dewerchin M & Carmeliet P: The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep, 14:2653-67, 2016.
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Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG: The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep, 12:1761-73, 2015.
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Snuderl M*, Batista A*, Kirkpatrick ND*, Ruiz de Almodovar C*, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK: Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell, 152:1065-76, 2013 (*equal contribution).
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Meissirel C*, Ruiz de Almodovar C*, Knevels E*, Coulon C, Chounlamountri N, Segura I, de Rossi P, Vinckier S, Anthonis K, Deléglise B, de Mol M, Ali C, Dassonville K, Loyens E, Honnorat J, Michotte Y, Rogemond V, Smolders I, Voets T, Vivien D, Vanden Berghe P, Van Den Bosch L, Robberecht W, Chédotal A, Oliviero S, Dewerchin M, Schmucker D, Thomasset N, Salin PA, Carmeliet P: VEGF modulates NMDA receptor activity via a Src-family-kinase-dependent cross-talk. Proc Natl Acad Sci U S A, 108:13782-7, 2011 (*equal contribution).
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Ruiz de Almodovar C, Fabre PJ, Knevels E, Coulon C, Segura I, Haddick PCG, Aerts L, Delattin N, Strasser G, Oh WJ, Lange C, Vinckier S, Haigh J, Fouquet C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F, Carmeliet P: VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron, 70:966-78, 2011 (*equal contribution).
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Storkebaum E*, Ruiz de Almodovar C*, Meens M, Zacchigna S, Mazzone M, Vanhoutte G, Vinckier S, Poesen K, Lambrechts D, Janssen G, Fazzi GE, Schiffers PM, Rohrer H, Van der Linden A, DeMey J & Carmeliet P: Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery. Circulation, 122:273-81, 2010 (*equal contribution).
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Ruiz de Almodovar C*, Coulon C*, Knevels E, Salin PA, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan, BJ Eriksson U, Moons L, D’Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Chedotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C: Matrix-binding VEGF isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci, 30:15052-66, 2010 (*equal contribution).