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Prof. Dr. Carmen Ruiz de Almodóvar

Project A2

Dept. Vascular Dysfunction

European Center for Angioscience (ECAS)

Faculty of Medicine Mannheim, Heidelberg University

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Carmen.ruizdealmodovar(at)medma.uni-heidelberg.de

Carmen Ruiz de Almodóvar obtained her PhD in Biochemistry from the University of Granada. She then moved on to pursue postdoctoral training in the laboratory of Peter Carmeliet at the Vesalius Research Center in Leuven before starting her own junior research group at the Biochemistry Center in Heidelberg. Since  September 2018 she is a full professor for Vascular Dysfunction at the Medical Faculty Mannheim.

Qualifications and Scientific Curriculum

1994-1999

1999-2004

2004-2011

2011-2018

since 2018

Biochemistry, University of Granada, Spain

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PhD student, CSIC – University of Granada, Spain

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Postdoctoral fellow, Vesalius Research Center (VRC), VIB – KU, Leuven, Belgium

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Junior Group leader at the Biochemistry Center (BZH) of University of Heidelberg, Germany

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W3 Professor for Vascular Dysfunction

Selected publications

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  1. Shen Y, Wang X*, Liu Y, Singhal M, Gurkaslar C, Freire-Valls A, Leis Y, Hu W, Schermann G, Adler H, Xu FY, Fischer T, Zhu Y, Augustin HG, Schmidt T*, Ruiz de Almodovar C*: STAT3-YAP/TAZ signaling in endothelial cells regulates tumor angiogenesis. Sci. Signal. 14:eabj8393. 2021. (*equal contribution)

  2. Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D`Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodovar C: The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morpho¬genesis in a cell-autonomous manner. Cell Rep. 36:109522, 2021.

  3. Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C: Oligodendrocyte precursor cell specification is regulated by bi-directional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 24:478-488, 2021.

  4. Tisch N, Ruiz de Almodóvar C: Contribution of cell death signaling to blood vessel formation. Cell Mol Life Sci. 78:3247-3264, 2021.

  5. Luck R*, Urban S*, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, Ruiz de Almodóvar C: VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. eLife. 8:e49818, 2019. (*equal contribution)

  6. Tisch N*, Freire-Valls A*, Yerbes R*, Paredes I, La Porta S, Wang X, Martín-Pérez R, Castro L, Wong WW, Coultas L, Strilic B, Gröne HJ, Hielscher T, Mogler C, Adams RH, Heiduschka P, Claesson Welsh L, Mazzone M, López-Rivas A, Schmidt T, Augustin HG, Ruiz de Almodovar C: Caspase-8 modulates physiological and pathological angiogenesis during retina development. J Clin Invest. 129:5092-5107, 2019. (*equal contribution)

  7. Karakatsani A, Shah B, Ruiz de Almodovar C: Blood vessels as regulators of neural stem cell properties. Front Mol Neurosci. 12:85, 2019.

  8. Paredes I, Himmels P, Ruiz de Almodovar C: Neuro-vascular communication in the CNS during development. Dev Cell. 45:10-32, 2018.

  9. Wang X, Freire Valls A, Shermann G, Shen X, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodovar C: YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell. 42:462-478.e7, 2017.

  10. Himmels P, Paredes I, Karakatsani A, Luck R, Marti H, Rempel E, Stoeckli E, Ruiz de Almodovar C: Motoneurons guide blood vessels in the developing spinal cord via a sFlt1 dependent mechanism. Nat Commun. 8:14583, 2017.