Prof. Dr. Carmen Ruiz de Almodóvar

Dept. Vascular Dysfunktion

European Center for Angioscience (ECAS)

Institute for Transfusion Medicine/Immunology

Faculty of Medicine Mannheim, Heidelberg University

Carmen.ruizdealmodovar(at)medma.uni-heidelberg.de

Carmen Ruiz de Almodóvar obtained her PhD in Biochemistry from the University of Granada. She then moved on to pursue postdoctoral training in the laboratory of Peter Carmeliet at the Vesalius Research Center in Leuven before starting her own junior research group at the Biochemistry Center in Heidelberg. Since  September 2018 she is a full professor for Vascular Dysfunction at the Medical Faculty Mannheim.

Qualifications and Scientific Curriculum

1994-1999

1999-2004

2004-2011

2011-2018

since 2018

Biochemistry, University of Granada, Spain

PhD student, CSIC – University of Granada, Spain

Postdoctoral fellow, Vesalius Research Center (VRC), VIB – KU, Leuven, Belgium

Junior Group leader at the Biochemistry Center (BZH) of University of Heidelberg, Germany

W3 Professor for Vascular Dysfunction

Selected publications

  1. Wang X, Freire Valls A, Schermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann L, Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C: YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell, 42:462-78, 2017.

  2. Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodovar C: Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun, 8:14583, 2017.

  3. Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A: CNS Macrophages Control Neurovascular Development via CD95L, Cell Rep,19:1378-93, 2017.

  4. Segura I, Lange C, Knevels E, Moskalyuk A, Pulizzi R, Eelen G, Chaze T, Tudor C, Boulegue C, Holt M, Daelemans D, Matondo M, Ghesquière B, Giugliano M, Ruiz de Almodovar C, Dewerchin M & Carmeliet P: The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep, 14:2653-67, 2016.

  5. Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG: The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep, 12:1761-73, 2015.

  6. Snuderl M*, Batista A*, Kirkpatrick ND*, Ruiz de Almodovar C*, Riedemann L, Walsh  EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK: Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell, 152:1065-76, 2013 (*equal contribution). 

  7. Meissirel C*, Ruiz de Almodovar C*, Knevels E*, Coulon C, Chounlamountri N, Segura I, de Rossi P, Vinckier S, Anthonis K, Deléglise B, de Mol M, Ali C, Dassonville K, Loyens E, Honnorat J, Michotte Y, Rogemond V, Smolders I, Voets T, Vivien D, Vanden Berghe P, Van Den Bosch L, Robberecht W, Chédotal A, Oliviero S, Dewerchin M, Schmucker D, Thomasset N, Salin PA, Carmeliet P: VEGF modulates NMDA receptor activity via a Src-family-kinase-dependent cross-talk. Proc Natl Acad Sci U S A, 108:13782-7, 2011 (*equal contribution).

  8. Ruiz de Almodovar C, Fabre PJ, Knevels E, Coulon C, Segura I, Haddick PCG, Aerts L, Delattin N, Strasser G, Oh WJ, Lange C, Vinckier S, Haigh J, Fouquet C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F, Carmeliet P: VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron, 70:966-78, 2011 (*equal contribution).

  9. Storkebaum E*, Ruiz de Almodovar C*, Meens M, Zacchigna S, Mazzone M, Vanhoutte G, Vinckier S, Poesen K, Lambrechts D, Janssen G, Fazzi GE, Schiffers PM, Rohrer H, Van der Linden A, DeMey J & Carmeliet P: Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery. Circulation, 122:273-81, 2010 (*equal contribution).

  10. Ruiz de Almodovar C*, Coulon C*, Knevels E, Salin PA, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan, BJ Eriksson U, Moons L, D’Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Chedotal A, Honnorat J, Thomasset N, Carmeliet P,  Meissirel C: Matrix-binding VEGF isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci, 30:15052-66, 2010 (*equal contribution).

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450