Division of Vascular Signaling and Cancer,

German Cancer Research Center Heidelberg (DKFZ)

Medical Clinic I, Heidelberg University Hospital

European Center for Angioscience (ECAS),

Medical Faculty Mannheim, Heidelberg University

 

a.fischer(at)dkfz.de

Andreas Fischer is Head of the Division of Vascular Signaling and Cancer at the German Cancer Research Center in Heidelberg. He attended Medical School at the University of Würzburg. As a predoctoral fellow he worked at the Children’s Hospital Boston at Harvard Medical School under the supervision of Stuart Orkin. He pursued postdoctoral research in the laboratory of Manfred Gessler at the Biocenter in Würzburg before he started his own Junior Research Group at the Medical Faculty in Mannheim. Since 2012 he is an independent group leader at the German Cancer Research Center.

Qualifications and Scientific Curriculum

MD, University of Würzburg

Postdoctoral fellow, Biocenter Würzburg

Junior group leader, CBTM, Medical Faculty Mannheim. Heidelberg University

Board certification Physiology

Independent group leader, German Cancer Research Center Heidelberg

Adjunct professorship at Heidelberg University

Clinical practice in laboratory medicine at Heidelberg University Hospital

Division Head, German Cancer Research Center Heidelberg

2003

2004-2007

2007-2012

2012

2012-2017

2016

since 2014

since 2017

Selected publications

  1. Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A: Inhibition of endothelial Notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart. Circulation, 137:2592-608, 2018.

  2. Tetzlaff F, Adam MG, Feldner A, Moll I, Menuchin A, Rodriguez-Vita J, Sprinzak D, Fischer A: MPDZ promotes DLL4-induced Notch signaling during angiogenesis. Elife, 7.pii:e32860, 2018.

  3. Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A: Endothelial Notch1 activity facilitates metastasis. Cancer Cell, 3:355-67, 2017.

  4. Feldner A, Adam MG, Tetzlaff F, Moll I, Komljenovic D, Sahm F, Bäuerle T, Ishikawa H, Schroten H, Korff T, Hofmann I, Wolburg H, von Deimling A, Fischer A: Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med, 9:890-905, 2017.

  5. Yang WJ, Hu J, Uemura A, Tetzlaff F, Augustin HG, Fischer A: Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis. EMBO Mol Med, 10:1267-84, 2015.

  6. Schulz GB, Wieland E, Wüstehube-Lausch J, Boulday G, Moll I, Tournier-Lasserve E, Fischer A: Cerebral cavernous malformation-1 protein controls DLL4-Notch3 signaling between the endothelium and pericytes. Stroke, 5:1337-43, 2015.

  7. Adam MG, Berger C, Feldner A, Yang WJ, Wüstehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes HP, Augustin HG, Fischer A: Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res, 113:1206-18, 2013.

  8. Wüstehube J, Bartol A, Liebler SS, Brütsch R, Zhu Y, Felbor U, Sure U, Augustin HG, Fischer A: Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A, 28:12640-5, 2010.

  9. Brütsch R, Liebler SS, Wüstehube J, Bartol A, Herberich SE, Adam MG, Telzerow A, Augustin HG, Fischer A: The integrin cytoplasmic domain-associated protein-1 (ICAP1) attenuates sprouting angiogenesis. Circ Res, 5:592-601, 2010.

  10. Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M: The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev, 8:901-11, 2004.

CRC1366

European Center for Angioscience

Medical Faculty Mannheim
Heidelberg University
Ludolf-Krehl-Straße 13-17
D-68167 Mannheim

Phone +49 621/383-71450